Paul Stang
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View article: Association between inflammatory joint disease and severe or treatment-resistant depression: population-based cohort and case-control studies in Sweden
Association between inflammatory joint disease and severe or treatment-resistant depression: population-based cohort and case-control studies in Sweden Open
IJD and depression are bidirectionally associated, but this association does not seem to be influenced by the severity or treatment resistance of depression.
View article: Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening
Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening Open
Background Patients and their loved ones often report symptoms or complaints of cognitive decline that clinicians note in free clinical text, but no structured screening or diagnostic data are recorded. These symptoms/complaints may be sig…
View article: Additional file 1 of Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening
Additional file 1 of Development of a machine learning model to predict mild cognitive impairment using natural language processing in the absence of screening Open
Additional file 1: NLP Dictionary.
View article: How well can post-traumatic stress disorder be predicted from pre-trauma risk factors? An exploratory study in the WHO World Mental Health Surveys
How well can post-traumatic stress disorder be predicted from pre-trauma risk factors? An exploratory study in the WHO World Mental Health Surveys Open
Post-traumatic stress disorder (PTSD) should be one of the most preventable mental disorders, since many people exposed to traumatic experiences (TEs) could be targeted in first response settings in the immediate aftermath of exposure for …
View article: Medications for attention‐deficit/hyperactivity disorder in Japan: A retrospective cohort study of label compliance
Medications for attention‐deficit/hyperactivity disorder in Japan: A retrospective cohort study of label compliance Open
Aim To assess label compliance in prescription of medications approved for treatment of attention‐deficit/hyperactivity disorder (ADHD) in Japan at the time of this study: methylphenidate (MPH), atomoxetine, and guanfacine. Methods Retrosp…
View article: Smoking and Suicidal Behaviors in the National Comorbidity Survey-Replication
Smoking and Suicidal Behaviors in the National Comorbidity Survey-Replication Open
Controversy exists about the role of mental disorders in the consistently documented association between smoking and suicidal behavior. This controversy is addressed here with data from the nationally representative National Comorbidity Su…
View article: Validation of a common data model for active safety surveillance research
Validation of a common data model for active safety surveillance research Open
Systematic analysis of observational medical databases for active safety surveillance is hindered by the variation in data models and coding systems. Data analysts often find robust clinical data models difficult to understand and ill suit…
Inferring disease severity in rheumatoid arthritis using predictive modeling in administrative claims databases Open
A prediction model demonstrated good discrimination across multiple claims databases to identify RA patients with a prescription claim for advanced therapies during different time-at-risk periods as proxy for current and future moderate-to…
View article: Medical Conditions Predictive of Self-Reported Poor Health: Retrospective Cohort Study
Medical Conditions Predictive of Self-Reported Poor Health: Retrospective Cohort Study Open
Background Identifying the medical conditions that are associated with poor health is crucial to prioritize decisions for future research and organizing care. However, assessing the burden of disease in the general population is complex, l…
View article: Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study
Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study Open
We observed a marked difference of the penetration patterns of newly marketed antidiabetics in different countries in Asia. Those results will provide the basic information useful in the future studies.
View article: Medical Conditions Predictive of Self-Reported Poor Health: Retrospective Cohort Study (Preprint)
Medical Conditions Predictive of Self-Reported Poor Health: Retrospective Cohort Study (Preprint) Open
BACKGROUND Identifying the medical conditions that are associated with poor health is crucial to prioritize decisions for future research and organizing care. However, assessing the burden of disease in the general population is complex, …
View article: Applying a common data model to Asian databases for multinational pharmacoepidemiologic studies: opportunities and challenges
Applying a common data model to Asian databases for multinational pharmacoepidemiologic studies: opportunities and challenges Open
The CDM established the foundation and reinforced collaboration for multinational pharmacoepidemiologic studies in Asia. Mapping of terminology codes was the greatest challenge, because of differences in health systems, cultures, and codin…
View article: Comparative effectiveness of canagliflozin, SGLT2 inhibitors and non‐SGLT2 inhibitors on the risk of hospitalization for heart failure and amputation in patients with type 2 diabetes mellitus: A real‐world meta‐analysis of 4 observational databases (OBSERVE‐4D)
Comparative effectiveness of canagliflozin, SGLT2 inhibitors and non‐SGLT2 inhibitors on the risk of hospitalization for heart failure and amputation in patients with type 2 diabetes mellitus: A real‐world meta‐analysis of 4 observational databases (OBSERVE‐4D) Open
Aims Sodium glucose co‐transporter 2 inhibitors (SGLT2i) are indicated for treatment of type 2 diabetes mellitus (T2DM); some SGLT2i have reported cardiovascular benefit, and some have reported risk of below‐knee lower extremity (BKLE) amp…
View article: Methods for time‐varying exposure related problems in pharmacoepidemiology: An overview
Methods for time‐varying exposure related problems in pharmacoepidemiology: An overview Open
Purpose Lack of control for time‐varying exposures can lead to substantial bias in estimates of treatment effects. The aim of this study is to provide an overview and guidance on some of the available methodologies used to address problems…
View article: Finding treatment-resistant depression in real-world data: How a data-driven approach compares with expert-based heuristics
Finding treatment-resistant depression in real-world data: How a data-driven approach compares with expert-based heuristics Open
The definition that best discriminates between subjects with and without TRD considers number of distinct antidepressants (≥3) or antipsychotics (≥1) in the last year.
View article: Risk of lower extremity amputations in people with type 2 diabetes mellitus treated with sodium‐glucose co‐transporter‐2 inhibitors in the USA: A retrospective cohort study
Risk of lower extremity amputations in people with type 2 diabetes mellitus treated with sodium‐glucose co‐transporter‐2 inhibitors in the USA: A retrospective cohort study Open
Aims To examine the incidence of amputation in patients with type 2 diabetes mellitus (T2DM) treated with sodium glucose co‐transporter 2 (SGLT2) inhibitors overall, and canagliflozin specifically, compared with non‐SGLT2 inhibitor antihyp…
View article: Incidence of diabetic ketoacidosis among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors and other antihyperglycemic agents
Incidence of diabetic ketoacidosis among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors and other antihyperglycemic agents Open
This was the first observational study that compared DKA risk between new users of SGLT2i and non-SGLT2i AHAs among patients with type 2 diabetes, and overall no statistically significant difference was detected.
View article: Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide
Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide Open
Depression is associated with high CRP levels and low FeNO levels. Of importance, this study (1) assesses the association of depression with CRP and exhaled NO levels in a large and representative sample of the US population, (2) contribut…
View article: Seasonality in acute liver injury? Findings in two health care claims databases
Seasonality in acute liver injury? Findings in two health care claims databases Open
No seasonal pattern was observed in the diagnosis of ALI. The positive and negative controls showed the expected patterns, strengthening the validity of the statistical and visual tests used for detecting seasonality.
View article: Switching from risperidone long-acting injectable to paliperidone long-acting injectable or oral antipsychotics
Switching from risperidone long-acting injectable to paliperidone long-acting injectable or oral antipsychotics Open
This report examines relapse risk following a switch from risperidone long-acting injectable (RLAI) to another long-acting injectable antipsychotic [paliperidone palmitate (PP)] versus a switch to oral antipsychotics (APs). Truven Health's…