Paul Stapleton
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View article: Towards a framework of critical thinking for assessing EAP speaking
Towards a framework of critical thinking for assessing EAP speaking Open
As one of the fundamental skills of the 21st century, critical thinking (CT) is a topic of considerable interest within the domain of assessing English for academic purposes (EAP). Recent literature on EAP instruction and assessment indica…
View article: Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant <i>Staphylococcus aureus</i>
Open Source Antibiotics: Simple Diarylimidazoles Are Potent against Methicillin-Resistant <i>Staphylococcus aureus</i> Open
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a…
View article: Open Source Antibiotics - Simple Diarylimidazoles are Potent Against Methicillin Resistant Staphylococcus Aureus
Open Source Antibiotics - Simple Diarylimidazoles are Potent Against Methicillin Resistant Staphylococcus Aureus Open
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a…
View article: Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance
Triazole-substituted phenylboronic acids as tunable lead inhibitors of KPC-2 antibiotic resistance Open
Inhibition of β-lactamases is a promising strategy to overcome antimicrobial resistance to commonly used β-lactam antibiotics. Boronic acid derivatives have proven to be effective inhibitors of β-lactamases due to their direct interaction …
View article: Amphotericin B Polymer Nanoparticles Show Efficacy against Candida Species Biofilms
Amphotericin B Polymer Nanoparticles Show Efficacy against Candida Species Biofilms Open
Purpose: Chronic infections of Candida albicans are characterised by the embedding of budding and entwined filamentous fungal cells into biofilms. The biofilms are refractory to many drugs and Candida biofilms are associated with ocular fu…
View article: Bioactive Compounds from the Bornean Endemic Plant Goniothalamus longistipetes
Bioactive Compounds from the Bornean Endemic Plant Goniothalamus longistipetes Open
The present study aimed to screen plants for bioactive compounds with potential antibacterial activities. In our efforts to evaluate plants from Borneo, we isolated and elucidated the structures of four natural products from the bioactive …
View article: Synthesis and in Silico Modelling of the Potential Dual Mechanistic Activity of Small Cationic Peptides Potentiating the Antibiotic Novobiocin against Susceptible and Multi-Drug Resistant Escherichia coli
Synthesis and in Silico Modelling of the Potential Dual Mechanistic Activity of Small Cationic Peptides Potentiating the Antibiotic Novobiocin against Susceptible and Multi-Drug Resistant Escherichia coli Open
Cationic antimicrobial peptides have attracted interest, both as antimicrobial agents and for their ability to increase cell permeability to potentiate other antibiotics. However, toxicity to mammalian cells and complexity have hindered de…
View article: <i>Myristica lowiana</i> Phytochemicals as Inhibitor of Plasmid Conjugation in <i>Escherichia coli</i>
<i>Myristica lowiana</i> Phytochemicals as Inhibitor of Plasmid Conjugation in <i>Escherichia coli</i> Open
Hexane extract and methanol fraction from the stem bark of Myristica lowiana specifically and significantly inhibited the conjugal transfer of the IncW plasmid R7K, a plasmid which harbors ampicillin‐, streptomycin‐, and spectinomycin‐resi…
View article: Counterargumentation at the primary level: An intervention study investigating the argumentative writing of second language learners
Counterargumentation at the primary level: An intervention study investigating the argumentative writing of second language learners Open
Theory of mind, the capacity to imagine the thoughts of others, is a remarkable human ability, and this gift is essential for students to acknowledge alternative views when writing argumentative essays. However, evidence shows that this gi…
View article: Bactericidal and antibiotic-modulation activities of methanol crude extracts of Ligustrum lucidum and Lobelia inflata against MRSA phenotypes: Molecular docking studies of some isolated compounds from both plants against DNA gyrase A
Bactericidal and antibiotic-modulation activities of methanol crude extracts of Ligustrum lucidum and Lobelia inflata against MRSA phenotypes: Molecular docking studies of some isolated compounds from both plants against DNA gyrase A Open
The present study evaluated antibacterial, plasmid conjugal transfer inhibition, growth kinetics and bacterial resistance modifying activities of methanol crude extracts from the fruits of Ligustrum lucidum (LLFE) and the leaves of Lobelia…
View article: Assessing the accuracy and teachers' impressions of Google Translate: A study of primary L2 writers in Hong Kong
Assessing the accuracy and teachers' impressions of Google Translate: A study of primary L2 writers in Hong Kong Open
• Primary 6 students wrote on the same topic in English and their native Chinese. • The Chinese scripts were translated into English using Google Translate (GT). • 12 teachers (without knowing about GT) graded the two sets of scripts. • Th…
View article: Identification of novel antimicrobial-producing bacteria from an ancient water source by Oxford Nanopore Whole Genome Sequencing and Natural Product Chemistry
Identification of novel antimicrobial-producing bacteria from an ancient water source by Oxford Nanopore Whole Genome Sequencing and Natural Product Chemistry Open
Microbially-derived antimicrobial compounds are a rich source of clinical antibiotic leads. However, discovery rates have declined over the past 40 years due, in part, to high rediscovery rates of known compounds from traditional soil-base…
View article: Antibacterial and norfloxacin potentiation activities of Ocimum americanum L. against methicillin resistant Staphylococcus aureus
Antibacterial and norfloxacin potentiation activities of Ocimum americanum L. against methicillin resistant Staphylococcus aureus Open
Staphylococcus species are among the most common resistant bacteria associated with the major cause of human ailments. The crude methanol extract from Ocimum americanum (OA) leaf was tested alone or in combination with norfloxacin (NOR) ag…
View article: A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections
A New Era of Pulmonary Delivery of Nano-antimicrobial Therapeutics to Treat Chronic Pulmonary Infections Open
Pulmonary infections may be fatal especially in immunocompromised patients and patients with underlying pulmonary dysfunction, such as those with cystic fibrosis, chronic obstructive pulmonary disorder, etc. According to the WHO, lower res…
View article: Self-emergent peer support using online social networking during cross-border transition
Self-emergent peer support using online social networking during cross-border transition Open
Transitioning from school to university is a major development for learners, often accompanied by difficulties. When overseas students arrive at university for the first time these challenges are multiplied. It is suggested, however, that …