Paul Van Schil
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View article: Lung Ischemia–Reperfusion Injury in Lung Transplant Surgery: Where Do We Stand?
Lung Ischemia–Reperfusion Injury in Lung Transplant Surgery: Where Do We Stand? Open
Lung ischemia–reperfusion injury (LIRI) remains a major contributor to perioperative morbidity and mortality in thoracic surgery, especially for lung transplantations, where it is one of the principal drivers of primary graft dysfunction (…
View article: Pathway-selective strategies reveal specific PI3K–mTOR inhibitors as key partners in KRAS G12D-targeted therapy
Pathway-selective strategies reveal specific PI3K–mTOR inhibitors as key partners in KRAS G12D-targeted therapy Open
KRAS G12D is the most common oncogenic mutation in pancreatic ductal adenocarcinoma (PDAC), driving resistance and heterogeneity. Using robotic high-throughput drug screening with live-cell imaging, we evaluated normalized organoid growth …
View article: Le TNM : la 9e édition pour l'oncologie thoracique
Le TNM : la 9e édition pour l'oncologie thoracique Open
View article: Differentiating Benign and Malignant Solitary Pulmonary Nodules Through Exhaled Breath Analysis
Differentiating Benign and Malignant Solitary Pulmonary Nodules Through Exhaled Breath Analysis Open
Lung cancer remains the leading cause of cancer-related deaths worldwide, with early detection significantly improving survival. Lung nodules are a common finding, both as incidental solitary pulmonary nodules (SPNs) and in lung cancer scr…
View article: Prognostic significance of micropapillary pattern and risk factors in patients with resected stage I lung adenocarcinoma and possible benefit of adjuvant therapy: a real-world multicenter study
Prognostic significance of micropapillary pattern and risk factors in patients with resected stage I lung adenocarcinoma and possible benefit of adjuvant therapy: a real-world multicenter study Open
MP component and risk factors might be considered critical features for patients with stage I lung adenocarcinomas and may inform the selection of patients who may benefit from adjuvant chemotherapy although no randomized evidence is avail…
View article: Comparative effectiveness of pembrolizumab-chemotherapy versus chemotherapy with/without bevacizumab in unresectable, locally advanced or metastatic non-small cell lung cancer: a Chinese multicenter real-world analysis emphasizing PD-L1-negative populations
Comparative effectiveness of pembrolizumab-chemotherapy versus chemotherapy with/without bevacizumab in unresectable, locally advanced or metastatic non-small cell lung cancer: a Chinese multicenter real-world analysis emphasizing PD-L1-negative populations Open
Pembrolizumab combined with chemotherapy may prolong survival in patients with PD-L1-negative advanced NSCLC, particularly those with squamous histology.
View article: An international and multidisciplinary EORTC survey on resectability of stage III non-small cell lung cancer
An international and multidisciplinary EORTC survey on resectability of stage III non-small cell lung cancer Open
This international and multidisciplinary survey showed agreement on the resectability for the majority of stage III NSCLC TNM-subsets, but also identified several TNM-subsets for which no agreement was found.
View article: Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases
Genome-wide DNA methylation analysis reveals a unique methylation pattern for pleural mesothelioma compared to healthy pleura and other lung diseases Open
View article: Prevalence and management of pulmonary nodules: a systematic review and meta-analysis
Prevalence and management of pulmonary nodules: a systematic review and meta-analysis Open
Overall, 27% of participants were positive for pulmonary nodules. Advancing age and smoking were consistently identified as a key risk factor for the incidence of pulmonary nodules. Although the management strategies are different across s…
View article: Disease relapse in relation to lymph node sampling in lung carcinoid patients
Disease relapse in relation to lymph node sampling in lung carcinoid patients Open
The predictive value of the extent of peri-operative lymph node (LN) sampling in relation to disease relapse in patients with pulmonary carcinoid (PC) is unknown. Furthermore, post-surgery follow-up recommendations rely on institutional re…
View article: Surgical treatment of thymic epithelial tumors: a narrative review
Surgical treatment of thymic epithelial tumors: a narrative review Open
New techniques in the field of minimally invasive surgery are gaining acceptance for early-stage TET but longer follow-up periods are warranted to prove their oncological outcomes. On the contrary, these techniques should be used cautiousl…
View article: A randomised phase II study of extended pleurectomy/decortication preceded or followed by chemotherapy in patients with early-stage pleural mesothelioma: EORTC 1205
A randomised phase II study of extended pleurectomy/decortication preceded or followed by chemotherapy in patients with early-stage pleural mesothelioma: EORTC 1205 Open
Background The role of surgery in pleural mesothelioma remains controversial. It may be appropriate in highly selected patients as part of a multimodality treatment including chemotherapy. Recent years have seen a shift from extrapleural p…
View article: Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax
Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax Open
OBJECTIVES The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendation…
View article: Table of Contents
Table of Contents Open
View article: Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax
Joint ERS/EACTS/ESTS clinical practice guidelines on adults with spontaneous pneumothorax Open
Background The optimal management for spontaneous pneumothorax (SP) remains contentious, with various proposed approaches. This joint clinical practice guideline from the ERS, EACTS and ESTS societies provides evidence-based recommendation…
View article: How to navigate an increasingly heterogeneous spectrum of resistance mechanisms in oncogene driven non-small cell lung cancer?
How to navigate an increasingly heterogeneous spectrum of resistance mechanisms in oncogene driven non-small cell lung cancer? Open
View article: Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition
Auranofin repurposing for lung and pancreatic cancer: low CA12 expression as a marker of sensitivity in patient-derived organoids, with potentiated efficacy by AKT inhibition Open
Background This study explores the repurposing of Auranofin (AF), an anti-rheumatic drug, for treating non-small cell lung cancer (NSCLC) adenocarcinoma and pancreatic ductal adenocarcinoma (PDAC). Drug repurposing in oncology offers a cos…
View article: The International Association for the Study of Lung Cancer (IASLC) Staging Project for Lung Cancer: Recommendation to Introduce Spread Through Air Spaces as a Histologic Descriptor in the Ninth Edition of the TNM Classification of Lung Cancer. Analysis of 4061 Pathologic Stage I NSCLC
The International Association for the Study of Lung Cancer (IASLC) Staging Project for Lung Cancer: Recommendation to Introduce Spread Through Air Spaces as a Histologic Descriptor in the Ninth Edition of the TNM Classification of Lung Cancer. Analysis of 4061 Pathologic Stage I NSCLC Open
View article: Self-Referred Screening Behavior for Lung Cancer: Are We Ready to Support?
Self-Referred Screening Behavior for Lung Cancer: Are We Ready to Support? Open
View article: The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revisions of the T-Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer
The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revisions of the T-Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer Open
View article: An Overview of the Use of Anti-Angiogenic Agents in the Treatment of Thymic Epithelial Tumors
An Overview of the Use of Anti-Angiogenic Agents in the Treatment of Thymic Epithelial Tumors Open
Angiogenesis significantly influences the carcinogenesis of thymic epithelial tumors (TET). Both thymomas and thymic carcinoma (TC) overexpress VEGF-A and VEGFR-1 and -2. This review aims to provide an appraisal of the use of anti-angiogen…
View article: The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: Proposals for the Revision of the N Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer
The International Association for the Study of Lung Cancer Staging Project for Lung Cancer: Proposals for the Revision of the N Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer Open
View article: Minimally Invasive Surgery in Non-Small Cell Lung Cancer: Where Do We Stand?
Minimally Invasive Surgery in Non-Small Cell Lung Cancer: Where Do We Stand? Open
In the last two decades, robotic-assisted thoracoscopic surgery (RATS) has gained popularity as a minimally invasive surgical (MIS) alternative to multi- and uniportal video-assisted thoracoscopic surgery (VATS). With this approach, the su…
View article: Immune-checkpoint inhibition for resectable non-small-cell lung cancer — opportunities and challenges
Immune-checkpoint inhibition for resectable non-small-cell lung cancer — opportunities and challenges Open
View article: True Prevalence of Unforeseen N2 Disease in NSCLC: A Systematic Review + Meta-Analysis
True Prevalence of Unforeseen N2 Disease in NSCLC: A Systematic Review + Meta-Analysis Open
Patients with unforeseen N2 (uN2) disease are traditionally considered to have an unfavorable prognosis. As preoperative and intraoperative mediastinal staging improved over time, the prevalence of uN2 changed. In this review, the current …
View article: Operable non-small cell lung cancer: induction therapy, adjuvant therapy, or both?
Operable non-small cell lung cancer: induction therapy, adjuvant therapy, or both? Open
View article: Innovative Invasive Loco-Regional Techniques for the Treatment of Lung Cancer
Innovative Invasive Loco-Regional Techniques for the Treatment of Lung Cancer Open
Surgical resection is still the standard treatment for early-stage lung cancer. A multimodal treatment consisting of chemotherapy, radiotherapy and/or immunotherapy is advised for more advanced disease stages (stages IIb, III and IV). The …
View article: Endosonography With or Without Confirmatory Mediastinoscopy for Resectable Lung Cancer: A Randomized Clinical Trial
Endosonography With or Without Confirmatory Mediastinoscopy for Resectable Lung Cancer: A Randomized Clinical Trial Open
PURPOSE Resectable non–small-cell lung cancer (NSCLC) with a high probability of mediastinal nodal involvement requires mediastinal staging by endosonography and, in the absence of nodal metastases, confirmatory mediastinoscopy according t…
View article: Sublobar Resection for Early-Stage Lung Cancer: An Oncologically Valid Procedure?
Sublobar Resection for Early-Stage Lung Cancer: An Oncologically Valid Procedure? Open
In the era of minimally invasive surgery, the role of sublobar resection comprising anatomical segmentectomy and wide wedge excision remains controversial [...]
View article: The anatomical variations of the additional communicating rami in the proximal sympathetic trunk: A human cadaveric study
The anatomical variations of the additional communicating rami in the proximal sympathetic trunk: A human cadaveric study Open
Background: In literature, four types of additional communicating branches of the sympathetic trunk are described. Data concerning location, presence, and variation of these rami are confusing and often incomplete. In this study, incidence…