Paul Willner
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A multicentred two-arm parallel single-blind superiority randomised controlled trial comparing psychological and emotional stabilisation with eye movement desensitisation and reprocessing and treatment-as-usual to treatment-as-usual with adults with intellectual disabilities who have post-traumatic stress disorder (the Trauma-AID trial): protocol Open
Introduction The primary objective of this clinical trial is to determine the clinical and cost-effectiveness of psychoeducation and emotional stabilisation (PES), together with eye movement desensitisation and reprocessing (EMDR) plus tre…
Fostering Open Science through the Arctic Permafrost Geospatial Center (APGC) Open
Open-access thematic data portals play a critical role in advancing an open data culture by addressing knowledge gaps and reducing uncertainties in research. The Arctic Permafrost Geospatial Center (APGC) serves as a pivotal platform for p…
Evaluation of an adapted version of the International Trauma Questionnaire for use by people with intellectual disabilities Open
Aims The International Trauma Questionnaire (ITQ) is a novel assessment instrument that is aligned to the ICD‐11 diagnoses of post‐traumatic stress disorder (PTSD) and complex PTSD (CPTSD). The purpose of this study was to develop and eval…
Models of Affective Illness: Chronic Mild Stress in the Rat Open
This article describes a chronic mild stress (CMS) model for predicting antidepressant response and investigating mechanisms of antidepressant action in rats. Following exposure to a variety of mild stressors for several weeks, the rats’ b…
Some observations on remote delivery of eye‐movement desensitisation and reprocessing to people with intellectual disabilities Open
It is increasingly recognised that many people with intellectual disabilities suffer from post‐traumatic stress disorder (PTSD). Eye‐movement desensitisation and reprocessing (EMDR) has been proposed as a potentially helpful intervention t…
Editorial: The Behavioural Pharmacology of Cannabinoids Open
Humans have been using cannabis preparations for thousands of years for a variety of purposes. The scientific study of cannabinoids has taken an impressive flight in the last few decades, fuelled by the discovery of endo-genous cannabinoid…
View article: Announcement of two special issues: behavioural pharmacology of synaptopathies and psychedelic drugs
Announcement of two special issues: behavioural pharmacology of synaptopathies and psychedelic drugs Open
Synaptopathies (Fall, 2022) Synaptic neurotransmission lies at the heart of nervous system's functioning. Clearly then, alterations in synaptic signal transduction can lead to a variety of neural disorders. Perhaps the most widely known of…
Insufficiency of ventral hippocampus to medial prefrontal cortex transmission explains antidepressant non-response Open
Background: There is extensive evidence that antidepressant drugs restore normal brain function by repairing damage to ventral hippocampus (vHPC) and medial prefrontal cortex (mPFC). While the damage is more extensive in hippocampus, the e…
Occupational stress, coping and wellbeing among registered psychologists working with people with intellectual disabilities during the COVID-19 pandemic in the United Kingdom Open
The wellbeing and occupational stress of psychologists working with people with intellectual disabilities have been affected during the pandemic. It is of note that almost a quarter of our sample reported having been redeployed.
Perspectives for therapy of treatment‐resistant depression Open
A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment‐resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past decade have novel treatments…
The Experiences of Carers of Adults With Intellectual Disabilities During the First <span>COVID</span>‐19 Lockdown Period Open
Background The recent COVID‐19 pandemic led to widespread international restrictions, severely impacting on health and social care services. For many individuals with an intellectual disability (ID) this meant reduced access to services an…
The experiences of mothers of children and young people with intellectual disabilities during the first COVID‐19 lockdown period Open
Background Recent COVID‐19 lockdown restrictions resulted in reduced access to educational, professional and social support systems for children with intellectual disabilities and their carers. Aim The aim of this study was to gain insight…
View article: Special Issue on the Behavioural Pharmacology of Cannabinoids
Special Issue on the Behavioural Pharmacology of Cannabinoids Open
Originally, this issue was planned for 2021. As a result of the Covid-19 pandemic, most of us have faced, and still are facing substantial delays in our work. For this reason, we have decided to postpone the Special Issue on the Behavioura…
View article: Translational Research in Behavioural Pharmacology
Translational Research in Behavioural Pharmacology Open
Increasing knowledge about disorders of the central nervous system in humans – better understanding the pathophysiology, developing more effective treatments, or both – is the long-term goal of a substantial portion of our animal studies. …
AMPA receptors mediate the pro-cognitive effects of electrical and optogenetic stimulation of the medial prefrontal cortex in antidepressant non-responsive Wistar–Kyoto rats Open
Background: The chronic mild stress (CMS) procedure is a widely used animal model of depression, and its application in Wistar–Kyoto (WKY) rats has been validated as a model of antidepressant-refractory depression. While not responding to …
Effect of the COVID‐19 pandemic on the mental health of carers of people with intellectual disabilities Open
Introduction The measures implemented to manage the COVID‐19 pandemic have been shown to impair mental health. This problem is likely to be exacerbated for carers. Method Informal carers (mainly parents) of children and adults with intelle…
The effect on and experience of families with a member who has Intellectual and Developmental Disabilities of the COVID-19 pandemic in the UK: developing an investigation Open
Click to increase image sizeClick to decrease image size Disclosure statementNo potential conflict of interest was reported by the authors.
Announcement of Special Issue: the behavioural pharmacology of cannabinoids Open
Cannabis is the most widely used illicit drug in the world, and humans have been using cannabis preparations for thousands of years. It was, however, the discovery of cannabinoid receptors and endogenous cannabinoid molecules in the late 1…
The behavioural pharmacology of opioids Open
Opiates have been used for both recreational and medical purposes by humans for thousands of years. The ‘recreational and medical’ in the previous sentence also describe the two main issues in opioid research today. On the one hand, opiate…
Behavioural aspects of neuroinflammation Open
Homeostatic control of the neuronal milieu is of fundamental importance for neuronal activity within and outside the central nervous system (CNS). Endogenous or exogenous factors can threaten this homeostasis, leading to the activation of …
The behavioural pharmacology of stress-related disorders Open
Our aim when planning this Special Issue was to showcase behavioural pharmacology research relevant to stress-related disorders, with a focus on lasting consequences of stress and a particular interest in post-traumatic stress disorder (PT…
Announcement of special issue for 2020: The behavioural pharmacology of opioids Open
The editors of Behavioural Pharmacology are pleased to announce that a Special Issue on The Behavioural Pharmacology of Opioids will be published in the spring of 2020. In each of the last 30 years, Behavioural Pharmacology has published a…
Announcement of Special Issues for 2019: Stress and Neuroinflammation Open
Two Special Issues of Behavioural Pharmacology are planned for 2019. As already announced, a Special Issue on The Behavioural Pharmacology of Stress-Related Disorders will be published in the spring of 2019, with a focus on paradigms in wh…
The chronic mild stress (CMS) model of depression: History, evaluation and usage Open
Now 30 years old, the chronic mild stress (CMS) model of depression has been used in >1300 published studies, with a year-on-year increase rising to >200 papers in 2015. Data from a survey of users show that while a variety of names are in…
Reliability of the chronic mild stress model of depression: A user survey Open
The chronic mild stress (CMS) model of depression is considered by many to be the animal model of depression that has the greatest validity and translational potential, but it has often been criticized for a perceived lack of reliability. …
Assessment of Anger-Related Cognitions of People with Intellectual Disabilities Open
Background: Interventions for anger represent the largest body of research on the adaptation of cognitive behavioural therapy (CBT) for people with intellectual disabilities. The extent to which the effectiveness of these interventions ref…
Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats Open
The fact that all three anti-dementia drugs reversed CMS-induced cognitive impairment and that cholinesterase inhibitors, but not memantine, have antidepressant-like effects in this model suggest that different mechanisms may underlie CMS-…