Paul Wolfson
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View article: T staging esophageal tumors with x rays
T staging esophageal tumors with x rays Open
With histopathology results typically taking several days, the ability to stage tumors during interventions could provide a step change in various cancer interventions. X-ray technology has advanced significantly in recent years with the i…
View article: Using Saliva Epigenetic Data to Develop and Validate a Multivariable Predictor of Esophageal Cancer Status
Using Saliva Epigenetic Data to Develop and Validate a Multivariable Predictor of Esophageal Cancer Status Open
Background: Salivary epigenetic biomarkers may detect esophageal cancer. Methods: A total of 256 saliva samples from esophageal adenocarcinoma patients and matched volunteers were analyzed with Illumina EPIC methylation arrays. Three datas…
View article: Endoscopic eradication therapy for Barrett’s esophagus–related neoplasia: a final 10-year report from the UK National HALO Radiofrequency Ablation Registry
Endoscopic eradication therapy for Barrett’s esophagus–related neoplasia: a final 10-year report from the UK National HALO Radiofrequency Ablation Registry Open
RFA treatment is effective and durable to prevent esophageal adenocarcinoma. Most treatment relapses occur early and can be successfully retreated.
View article: PMO-3 The SPIT study: Creating a saliva based epigenetic biomarker panel to diagnose crohn’s disease
PMO-3 The SPIT study: Creating a saliva based epigenetic biomarker panel to diagnose crohn’s disease Open
Introduction The SPIT study (ISRCTN11921553) aims to investigate the methylation changes in saliva that result from Crohn’s disease with the ultimate aim of developing a diagnostic biomarker. Aims and Methods We selected 192 volunteers, 96…
View article: OFR-2 The SPIT study: creating a saliva based epigenetic biomarker panel to diagnose oesophgeal cancer
OFR-2 The SPIT study: creating a saliva based epigenetic biomarker panel to diagnose oesophgeal cancer Open
Introduction The SPIT study aims to investigate the methylation changes in saliva that result from oesophagael cancer with the ultimate aim of developing a diagnostic biomarker. Methods We recruited volunteers with adenocarcinoma, intramuc…
View article: PTH-72 A symptom and risk factor questionnaire accurately predicts upper gastrointestinal cancer
PTH-72 A symptom and risk factor questionnaire accurately predicts upper gastrointestinal cancer Open
Introduction Waiting times for endoscopy are rising rapidly following the COVID-19 pandemic. In addition, cancers may be missed as patients are placed on routine waiting lists but not monitored. Some hospitals use the Edinburgh Dysphagia S…
View article: Accuracy of clinical staging for T2N0 oesophageal cancer: systematic review and meta-analysis
Accuracy of clinical staging for T2N0 oesophageal cancer: systematic review and meta-analysis Open
Summary Oesophageal cancer is the sixth commonest cause of overall cancer mortality. Clinical staging utilizes multiple imaging modalities to guide treatment and prognostication. T2N0 oesophageal cancer is a treatment threshold for neoadju…
View article: P239 X-ray phase contrast imaging for staging oesophageal tumours: preliminary results from the VIOLIN study
P239 X-ray phase contrast imaging for staging oesophageal tumours: preliminary results from the VIOLIN study Open
Introduction Oesophageal cancer is the 7th commonest cause of cancer death worldwide. Radiological staging of local oesophageal cancer is inaccurate. CT currently relies on attenuation of x-rays to generate contrast. Soft tissues have very…
View article: O29 Time to CRD and subsequent relapses: ten year follow up from the UK patient registry
O29 Time to CRD and subsequent relapses: ten year follow up from the UK patient registry Open
Background Radiofrequency ablation (RFA) and endoscopic mucosal resection (EMR) are first line therapy for patients with dysplastic Barrett's oesophagus (BE) or intramucosal carcinoma (IMC) to prevent oesophageal adenocarcinoma (OAC). We a…
View article: P240 Accuracy of clinical staging for T2N0 oesophageal cancer: systematic review and meta-analysis
P240 Accuracy of clinical staging for T2N0 oesophageal cancer: systematic review and meta-analysis Open
Background and Aims Oesophageal cancer is the 7th most common cause of cancer worldwide and is the 6th most common cause of overall cancer mortality. Clinical staging utilises multiple imaging modalities and is the most appropriate guide f…
View article: P28 Comparison of anxiety and depression scores between 2-week wait and Barrett’s surveillance endoscopy referrals
P28 Comparison of anxiety and depression scores between 2-week wait and Barrett’s surveillance endoscopy referrals Open
Introduction BSG guidelines recommend endoscopic surveillance for patients with Barrett's oesophagus (BE), due to the 0.5% annual risk of developing oesophageal adenocarcinoma.1 Approximately 10% of GP 2-week wait (2WW) referrals result in…
View article: OTU-18 Using X-ray phase contrast imaging to identify oesophageal pathology
OTU-18 Using X-ray phase contrast imaging to identify oesophageal pathology Open
Introduction Oesophageal cancer is the 5th commonest cause of cancer death in the UK. It accounts for 9,000 new cancer cases every year. Most oesophageal cancers are diagnosed at a late stage. Survival data shows that patients with early d…
View article: Challenges in screening for latent tuberculosis in inflammatory bowel disease prior to biologic treatment: a UK cohort study
Challenges in screening for latent tuberculosis in inflammatory bowel disease prior to biologic treatment: a UK cohort study Open
Objective The aim of this study was to determine the occurrence of latent tuberculosis infections (LTBI) and active TB in a cohort of patients with inflammatory bowel disease (IBD) treated with biologics. We also examined the effects of im…
View article: P439 Diagnosis and management of latent and active tuberculosis in the context of biologic therapy in inflammatory bowel disease
P439 Diagnosis and management of latent and active tuberculosis in the context of biologic therapy in inflammatory bowel disease Open
Background: Anti-TNF treatments have improved the outcomes for patients with inflammatory bowel disease (IBD). However, they are associated with an increase in risk of Tuberculosis (TB). The aim of this study is to determine the proportion…
View article: A new form of gastric banding
A new form of gastric banding Open
A 23-year-old woman with a history of Turners mosaicism, learning difficulties and Crohn's disease presented with bloody diarrhoea and abdominal pain. Colonoscopy revealed a pancolitis with histology confirming a severe colitis with acute …