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View article: Association Between Prophylactic Anti‐Seizure Medication and Early Post‐Traumatic Seizures: An International Observational Multicenter Study
Association Between Prophylactic Anti‐Seizure Medication and Early Post‐Traumatic Seizures: An International Observational Multicenter Study Open
Evidence for the use of prophylactic anti‐seizure medication (ASM) in traumatic brain injury (TBI) in reducing the occurrence of early post‐traumatic seizure (EPTS) remains equivocal. This study aimed to analyze the prevalence of EPTS in c…
View article: Intra-cranial pressure monitoring is associated with lower in-hospital mortality but not with improved functional outcomes in pediatric traumatic brain injury: a multicenter observational study
Intra-cranial pressure monitoring is associated with lower in-hospital mortality but not with improved functional outcomes in pediatric traumatic brain injury: a multicenter observational study Open
Background Evidence that the use of invasive intracranial pressure (ICP) monitoring improves outcomes in severe traumatic brain injury (sTBI) remains equivocal. We investigated the association between invasive ICP monitoring and mortality,…
View article: Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury
Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children With Traumatic Brain Injury Open
Importance The use of hypertonic saline (HTS) vs mannitol in the control of elevated intracranial pressure (ICP) secondary to neurotrauma is debated. Objective To compare mortality and functional outcomes of treatment with 3% HTS vs 20% ma…
View article: Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study
Prevalence, aetiology, and hospital outcomes of paediatric acute critical illness in resource-constrained settings (Global PARITY): a multicentre, international, point prevalence and prospective cohort study Open
For the French, Portuguese and Spanish translations of the abstract see Supplementary Materials section.
View article: Identifying Clinical Predictors of Raised Intracranial Pressure in Pediatric Traumatic Brain Injury—A Multinational Initiative
Identifying Clinical Predictors of Raised Intracranial Pressure in Pediatric Traumatic Brain Injury—A Multinational Initiative Open
Use of the intracranial pressure (ICP) monitor in pediatric traumatic brain injury (TBI) remains variable. Clinical prediction models of raised ICP have been reported in adult TBI but have not been validated in pediatric TBI. We aimed to i…
View article: Challenges in institutional ethical review process and approval for international multicenter clinical studies in lower and middle-income countries: the case of PARITY study
Challenges in institutional ethical review process and approval for international multicenter clinical studies in lower and middle-income countries: the case of PARITY study Open
Background One of the greatest challenges to conducting multicenter research studies in low and middle-income countries (LMICs) is the heterogeneity in regulatory processes across sites. Previous studies have reported variations in require…
View article: Risk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America
Risk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America Open
This study identified key risk factors for predicting NRS failure in children with acute ARF in PICUs, including younger age, prematurity, malnutrition, suspected bacterial infection, FiO2 >30 %, severe hypoxemia (SpO2/FiO2 ≤150), tachypne…
View article: Challenges in Institutional Ethical Review Process and Approval for International Multicenter Clinical Studies in Lower and Middle-Income Countries: the case of PARITY Study
Challenges in Institutional Ethical Review Process and Approval for International Multicenter Clinical Studies in Lower and Middle-Income Countries: the case of PARITY Study Open
Objectives To describe the regulatory process, variability and challenges faced by pediatric researchers in low- and middle-income countries (LMICs) during the institutional review board (IRB) process of an international multicenter observ…
View article: Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings
Global PARITY: Study Design for a Multi-Centered, International Point Prevalence Study to Estimate the Burden of Pediatric Acute Critical Illness in Resource-Limited Settings Open
Background The burden of pediatric critical illness and resource utilization by children with critical illness in resource limited settings (RLS) are largely unknown. Without specific data that captures key aspects of critical illness, dis…
View article: Uncovering Causes of Childhood Death Using the Minimally Invasive Autopsy at the Community Level in an Urban Vulnerable Setting of Argentina: A Population-Based Study
Uncovering Causes of Childhood Death Using the Minimally Invasive Autopsy at the Community Level in an Urban Vulnerable Setting of Argentina: A Population-Based Study Open
Background Precise determination of the causal chain that leads to community deaths in children in low- and middle-income countries is critical to estimating all causes of mortality accurately and to planning preemptive strategies for targ…
View article: Community Mortality Due to Respiratory Syncytial Virus in Argentina: Population-based Surveillance Study
Community Mortality Due to Respiratory Syncytial Virus in Argentina: Population-based Surveillance Study Open
Background Many deaths in infants from low-middle income countries (LMICs) occur at home or upon arrival to health facilities. Although acute lower respiratory tract illness plays an important role in community mortality, the accuracy of m…