Paula Fernanda Kinoshita
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View article: Ouabain increases neuronal differentiation of hippocampal neural precursor cells
Ouabain increases neuronal differentiation of hippocampal neural precursor cells Open
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View article: Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondrial alterations in fibroblasts from sporadic Alzheimer's disease (AD) patients correlate with AD-related clinical hallmarks Open
Mitochondrial dysfunctions are key features of Alzheimer’s disease (AD). The occurrence of these disturbances in the peripheral cells of AD patients and their potential correlation with disease progression are underinvestigated. We studied…
View article: The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease Open
View article: Ouabain Increases Neuronal Differentiation of Hippocampal Neural Precursor Cells
Ouabain Increases Neuronal Differentiation of Hippocampal Neural Precursor Cells Open
View article: Mitochondria alterations in fibroblasts from sporadic Alzheimer’s disease (AD) patients correlate with AD-related clinical hallmarks
Mitochondria alterations in fibroblasts from sporadic Alzheimer’s disease (AD) patients correlate with AD-related clinical hallmarks Open
INTRODUCTION Mitochondria dysfunctions are key features in Alzheimer’s disease (AD). The occurrence of these disturbances in AD patient’s peripheral cells and their potential correlation with disease progression are under investigated. MET…
View article: Ouabain increases neuronal differentiation of hippocampal neural precursor cellsRunning title: Role of Ouabain in neurogenesis
Ouabain increases neuronal differentiation of hippocampal neural precursor cellsRunning title: Role of Ouabain in neurogenesis Open
It has been shown that Ouabain (OUA), a cardiotonic steroid, can bind to Na,K-ATPase (NKA) and trigger many signaling pathways in adult rat hippocampus such as cAMP response element-binding protein (CREB), Wnt/β-catenin and NF-κB in neuron…
View article: The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease
The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease Open
Mitochondria dysfunctions and mitophagy failure have been associated with several Alzheimer’s disease (AD) related molecular actors including amyloid beta (Aβ) and recently the amyloid precursor protein-C terminal fragments (APP-CTFs). The…
View article: Effect of Ouabain on Glutamate Transport in the Hippocampus of Rats with LPS-Induced Neuroinflammation
Effect of Ouabain on Glutamate Transport in the Hippocampus of Rats with LPS-Induced Neuroinflammation Open
A lipopolysaccharide (LPS)-induced neuroinflammation rat model was used to study the effects of ouabain (OUA) at low concentrations, which can interact with the Na,K-ATPase, causing the modulation of intracellular signalling pathways in th…
View article: Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice
Consequences of the Lack of TNFR1 in Ouabain Response in the Hippocampus of C57BL/6J Mice Open
Ouabain is a cardiac glycoside that has a protective effect against neuroinflammation at low doses through Na+/K+-ATPase signaling and that can activate tumor necrosis factor (TNF) in the brain. TNF plays an essential role in neuroinflamma…
View article: Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture
Neuroprotective action of α-Klotho against LPS-activated glia conditioned medium in primary neuronal culture Open
The α-Klotho is an anti-aging protein that, when overexpressed, extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytoki…
View article: Effect of ouabain on glutamate transport in the hippocampus of rats with LPS-induced neuroinflammation
Effect of ouabain on glutamate transport in the hippocampus of rats with LPS-induced neuroinflammation Open
A lipopolysaccharide (LPS)-induced neuroinflammation rat model was used to study the effects of ouabain (OUA) at low concentrations, which can interact with the Na, K-ATPase, causing the modulation of intracellular signalling pathways in t…
View article: Neuroprotective action of α-Klotho against LPS- activated glia conditioned medium in primary neuronal culture
Neuroprotective action of α-Klotho against LPS- activated glia conditioned medium in primary neuronal culture Open
The α-Klotho is an anti-aging protein that when overexpressed extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytokine…
View article: Neuroprotective action of α-Klotho against LPS- activated glia conditioned medium in primary neuronal culture
Neuroprotective action of α-Klotho against LPS- activated glia conditioned medium in primary neuronal culture Open
The α-Klotho is an anti-aging protein that when overexpressed extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytokine…
View article: Neuroprotective action of α-Klotho against LPS- activated glia conditioned medium in primary neuronal culture.
Neuroprotective action of α-Klotho against LPS- activated glia conditioned medium in primary neuronal culture. Open
The α-Klotho is an anti-aging protein that when overexpressed extends the life span in humans and mice. It has an anti-inflammatory and protective action on renal cells by inhibiting NF-κB activation and production of inflammatory cytokine…
View article: A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy
A missense mutation converts the Na+,K+-ATPase into an ion channel and causes therapy-resistant epilepsy Open
The ion pump Na+,K+-ATPase is a critical determinant of neuronal excitability; however, its role in the etiology of diseases of the central nervous system (CNS) is largely unknown. We describe here the molecular pheno…
View article: The Role of GPNMB in Inflammation
The Role of GPNMB in Inflammation Open
Inflammation is a response to a lesion in the tissue or infection. This process occurs in a specific manner in the central nervous system and is called neuroinflammation, which is involved in neurodegenerative diseases. GPNMB, an endogenou…
View article: The Janus face of ouabain in Na<sup>+</sup>/K<sup>+</sup>‐ATPase and calcium signalling in neurons
The Janus face of ouabain in Na<sup>+</sup>/K<sup>+</sup>‐ATPase and calcium signalling in neurons Open
Na + /K + ‐ATPase, a transmembrane protein essential for maintaining the electrochemical gradient across the plasma membrane, acts as a receptor for cardiotonic steroids such as ouabain. Cardiotonic steroids binding to Na + /K + ‐ATPase tr…
View article: Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease
Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is a multifactorial neurodegenerative pathology characterized by a progressive decline of cognitive functions. Alteration of various signaling cascades affecting distinct subcellular compartment functions and their…
View article: The Janus face of Ouabain in Na+, K+-ATPase and calcium signalling in neurons
The Janus face of Ouabain in Na+, K+-ATPase and calcium signalling in neurons Open
Na+,K+ATPase (NKA), a transmembrane protein essential for maintaining the electrochemical gradient across the plasma membrane, acts as a receptor for cardiotonic steroids (CTS) such as ouabain. CTS binding to NKA, triggers signalling pathw…
View article: Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains Open
View article: Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway
Tumor necrosis factor receptor-associated factor 6 interaction with alpha-synuclein enhances cell death through the Nuclear Factor-kB pathway Open
View article: Ouabain increases neuronal branching in hippocampus and improves spatial memory
Ouabain increases neuronal branching in hippocampus and improves spatial memory Open
View article: Ouabain attenuates the oxidative stress induced by lipopolysaccharides in the cerebellum of rats
Ouabain attenuates the oxidative stress induced by lipopolysaccharides in the cerebellum of rats Open
Our study aimed to analyze the effect of ouabain administration on lipopolysaccharide (LPS)‐induced changes in oxidative parameters, membrane lipid composition, and the activities of some important enzymes of the nervous system. The conten…
View article: Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders
Neuroinflammation and Neurotransmission Mechanisms Involved in Neuropsychiatric Disorders Open
Some classical psychiatric disorders, such as schizophrenia, autism, major depression, bipolar and obsessive‐compulsive disorders, have been related to neuroinflammatory process, immunological abnormalities, and neurotransmission impairmen…
View article: Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells
Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells Open
View article: The Influence of Na+, K+-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence
The Influence of Na+, K+-ATPase on Glutamate Signaling in Neurodegenerative Diseases and Senescence Open
Decreased Na(+), K(+)-ATPase (NKA) activity causes energy deficiency, which is commonly observed in neurodegenerative diseases. The NKA is constituted of three subunits: α, β, and γ, with four distinct isoforms of the catalytic α subunit (…
View article: Cardiotonic Steroids as Modulators of Neuroinflammation
Cardiotonic Steroids as Modulators of Neuroinflammation Open
Cardiotonic steroids (CTS) are a class of specific ligands of the Na(+), K(+)- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gr…
View article: Ouabain Modulates the Lipid Composition of Hippocampal Plasma Membranes from Rats with LPS-induced Neuroinflammation
Ouabain Modulates the Lipid Composition of Hippocampal Plasma Membranes from Rats with LPS-induced Neuroinflammation Open
View article: Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus
Effects of intermittent fasting on age-related changes on Na,K-ATPase activity and oxidative status induced by lipopolysaccharide in rat hippocampus Open