Explanipedia

Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity Open

Eduard Daura, Saara Tegelberg, Paula Hakala, Anna‐Elina Lehesjoki, Tarja Joensuu · 2022

Cystatin B (CSTB) is a cysteine cathepsin inhibitor whose biallelic loss-of-function mutations in human result in defects in brain development and in neurodegeneration. The physiological function of CSTB is largely unknown, and the mechani…

Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis Open

Eduard Daura, Saara Tegelberg, Masahito Yoshihara, Christopher B. Jackson, Francesca Simonetti , et al. · 2021

Ectopic histone clipping in the mouse model of progressive myoclonus epilepsy Open

Eduard Daura, Saara Tegelberg, Masahito Yoshihara, Christopher B. Jackson, Francesca Simonetti , et al. · 2020

We establish cystatin B (CSTB) as a regulator of histone H3 tail clipping in murine neural progenitor cells (NPCs) and provide evidence suggesting that epigenetic dysregulation contributes to the early pathogenesis in brain disorders assoc…

Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia Open

Inken Körber, Shintaro Katayama, Elísabet Einarsdóttir, Kaarel Krjutškov, Paula Hakala , et al. · 2016

Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1, OMIM254800) is an autosomal recessive neurodegenerative disorder characterized by stimulus-sensitive and action-activated myoclonus, tonic-clonic epileptic seizures, and ata…

Ravitsemuskuntoutuksen toteutuminen Kelan järjestämillä kuntoutuskursseilla Open

Paula Hakala, Tuula Toikka, M Paturi, I. Autti‐Rämö · 2015

Ravitsemuskuntoutuksella (ravitsemusneuvonta ja ruokatarjonta) on erityisen tärkeä merkitys ravitsemukseen liittyvien sairauksien hoidossa ja ehkäisyssä. Sillä voidaan vaikuttaa myönteisesti myös kuntoutujien toiminta- ja työkykyyn sekä el…

Paula Hakala YOU? Author Swipe