Explanipedia

Inflammatory bowel like disease with ileocolic and perianal involvement induced by ocrelizumab: a case report Open

Â. Domingues, Ana Catarina Carvalho, Diana Martins, Eugénia Cancela, Américo Silva , et al. · 2025

Immune-mediated colitis (IMC) is a common immune related adverse event associated with immune checkpoint inhibitors. Other classes of biological therapy, such as monoclonal antibody with anti-CD20 activity, have also been associated with d…

IBD-PODCAST Portugal: Proportion of Patients with Suboptimal Disease Control and Its Impact on Quality of Life in Inflammatory Bowel Disease Open

Helena Tavares de Sousa, Viviana Martins, Paula Ministro, Catarina Dantas Rodrigues, Luís Correia , et al. · 2025

Introduction: Ulcerative colitis (UC) and Crohn’s disease (CD) are inflammatory bowel diseases (IBDs) characterised by chronic inflammation of the digestive tract. Patients with IBD often present a suboptimal disease control due to the lim…

Predicting resistance to biological therapy using human leukocyte antigen genes in patients with inflammatory bowel disease Open

Â. Domingues, Ana Luı́sa Carvalho, António Martinho, Caroline Soares, Diana Martins , et al. · 2025

Background: The efficacy of anti-tumor necrosis factor (TNF) therapy in inflammatory bowel disease (IBD) is often compromised by the development of antidrug antibodies. In this setting, the human leukocyte antigen (HLA)-DQA1*05 allele has …

Oral health in inflammatory bowel disease: the overlooked impact and the potential role of salivary calprotectin Open

Cláudio Rodrigues, Ana T. P. C. Gomes, Joana Leal, Pedro Pereira Rodrigues, Pedro C. Lopes , et al. · 2025

Background Inflammatory Bowel Disease (IBD), a chronic condition characterized by gastrointestinal inflammation, is influenced by genetic and environmental factors. Emerging evidence suggests a “mouth-gut axis,” with the oral cavity reflec…

Hot Topics on Nutrition in IBD Open

Caroline Cibele Vieira Soares, Paula Ministro · 2024

Inflammatory bowel diseases (IBD) affect primarily the bowel, but they are multisystemic diseases with a wide range of extraintestinal manifestations and complications. Nutritional imbalance occurs frequently in patients with IBD. The spec…

P1236 Oral microbiota dysbiosis in Inflammatory Bowel Disease patients Open

Catarina Dantas Rodrigues, Ana T. P. C. Gomes, Karina Mendes, Maria José Correia, Paulo Almeida Pereira , et al. · 2024

Background Recent data pointed that IBD is strictly related to gut microbiota although less is known about the connection between oral microbiota and IBD. It is also known that dysbiosis can lead to oral pathologies. Moreover, microbiome c…

P222 Inflammatory Bowel Disease and cardiac function: a systematic review of literature with meta-analysis Open

C Soares, J G Fiuza, Cláudio Rodrigues, J. Gil, N Craveiro , et al. · 2024

Background Morphological and functional cardiac involvement is rarely seen in inflammatory bowel disease (IBD) patients but there is evidence that IBD patients have an increased risk of cardiovascular events despite the lower prevalence of…

P430 The influence of persistent organ damage on IFX pharmacokinetic modeling and disease progression assessment: findings from a prospective real-world study in inflammatory bowel disease patients Open

Fernando Magro, Samuel Fernandes, Marta Patita, Bruno Arroja, Paula Lago , et al. · 2024

Background Effective management of inflammatory bowel disease (IBD) relies on a comprehensive understanding of infliximab (IFX) pharmacokinetics (PK). This study's primary goal was to develop a robust PK model, identifying key covariates i…

Inflammatory bowel disease and cardiac function: a systematic review of literature with meta-analysis Open

Caroline Soares, J G Fiuza, Cláudio Rodrigues, N Craveiro, Júlio Gil , et al. · 2024

Background: Morphological and functional cardiac involvement is rarely described in patients with inflammatory bowel disease (IBD) but there is evidence that they have an increased risk of cardiovascular (CV) events despite the lower preva…

P137 Salivary calprotectin: a potential biomarker in inflammatory bowel disease? Open

Cláudio Rodrigues, Ana T. P. C. Gomes, J Leal, Karina Mendes, Maria José Correia , et al. · 2024

Background Background: Biomarkers are used frequently for evaluation and monitoring of IBD. Fecal calprotectin (FCP) is an already established biomarker in IBD, nevertheless patients often do not feel comfortable with stool manipulation. A…

P1216 Oral Health status in Inflammatory Bowel Disease patients Open

Cláudio Rodrigues, Ana T. P. C. Gomes, Karina Mendes, Maria José Correia, Nuno Rosa , et al. · 2024

Background Inflammatory bowel diseases (IBD) affect de gastrointestinal tract primarily as it occurs in oral Crohn´s disease (CD) or as an extraintestinal manifestation (EIM) as aphthous stomatitis either in CD or ulcerative colitis (UC). …

Thiopurines have no impact on outcomes of Crohn's disease patients beyond 12 months of maintenance treatment with infliximab Open

Paula Sousa, Marta Patita, Bruno Arroja, Paula Lago, Isadora Rosa , et al. · 2023

In CD patients in maintenance treatment with infliximab, combination treatment does not seem to have benefits over infliximab monotherapy beyond 12 months of treatment duration.

Persistent Fever after COVID-19 Vaccination in a Patient with Ulcerative Colitis: A Call for Attention Open

Cláudio Rodrigues, Ana Catarina Carvalho, Sofia Ventura, Â. Domingues, Américo Silva , et al. · 2023

The development of vaccinations has been game-changing in the ongoing effort to combat the COVID-19 pandemic. Until now, adverse effects are being reported at low frequency, including thrombocytopenia and myocarditis. Careful monitoring fo…

How many biomarker measurements are needed to predict prognosis in Crohn's disease patients under infliximab?—A prospective study Open

Fernando Magro, María Manuela Estevinho, Gaia Catalano, Marta Patita, Bruno Arroja , et al. · 2023

Background Timely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. Ob…

P734 A single measurement of fecal calprotectin, particularly if combined with hemoglobin and C-reactive protein levels, predicts Crohn’s disease prognosis - a prospective study Open

Fernando Magro, María Manuela Estevinho, G Catalano, Marta Patita, Bruno Arroja , et al. · 2023

Background Early flare prediction is essential for the timely management of Crohn’s disease (CD) patients, allowing to optimize the available therapeutic toolbox and to decrease the disease burden. We aimed to evaluate the performance of r…

P288 Application of a new classification of Fistulizing Perianal Crohn’s Disease (FPCD) in clinical practice: evaluating the correlation between clinician and patient’s assessments and FPCD patient′s quality of life Open

Cláudio Rodrigues, Filipe Giordano Valerio, Carlos Casimiro, C Soares, Sofia Ventura , et al. · 2023

Background FPCD remains a challenging condition with negative impact on quality of life. Recently, a novel classification was proposed intending to optimize and standardize the management of these patients (Geldof J, et al. Lancet Gastroen…

Diagnosis of Bowel Endometriosis Using Endoscopic Ultrasound-guided Fine Needle Aspiration Open

Ana Catarina Carvalho, Ricardo Cardoso, Francisco Pires, Sofia Ventura, Francisco Portela , et al. · 2023

Endometriosis is a relatively common gynecological condition in women of reproductive age. The rectosigmoid region is the most commonly affected segment when the gastrointestinal tract is involved. A differential diagnosis of colorectal ne…

A survey on the impact of IBD in sexual health: Into intimacy Open

Francisco Pires, Diana Martins, Paula Ministro · 2022

Patients with Inflammatory Bowel Disease (IBD) are at increased risk of psychological and physical burden, including sexual dysfunction (SD). This study aimed to assess the prevalence of SD and to identify its predictive factors, in IBD pa…

Transmural remission improves clinical outcomes up to 5 years in Crohn's disease Open

Samuel Fernandes, Juliana Serrazina, I Botto, Tiago Leal, Andreia Guimarães , et al. · 2022

Introduction Evidence supporting transmural remission ( TR ) as a long‐term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic ( IER ) or radiologic remissio…

Incidence Trends of Inflammatory Bowel Disease in a Southern European Country: A Mirror of the Western World? Open

Mafalda Santiago, Francisco Stocker, Paula Ministro, Raquel Gonçalves, Diana Carvalho , et al. · 2022

INTRODUCTION: Inflammatory bowel disease (IBD) affects people from all age categories worldwide. Although the incidence of the disease is stabilizing or decreasing in most Western world countries, its prevalence is still increasing because…

Composite outcomes in observational studies of Crohn’s disease: a systematic review and meta-analysis Open

Fernando Magro, Catarina Sottomayor, Catarina Alves, Mafalda Santiago, Paula Ministro , et al. · 2022

Background: This systematic review and meta-analysis aims to assess composite and aggregate outcomes of observational studies in Crohn’s disease and to evaluate whether the number and type of variables included affect the frequency of the …

Inflammatory bowel disease and thromboembolic events: a c’lot to learn Open

Ana Catarina Carvalho, Juliana Pinho, Eugénia Cancela, Hugo Marcelo Vieira, Américo Silva , et al. · 2022

Background: Inflammatory bowel disease (IBD) is associated with a variety of extraintestinal manifestations including arterial and venous thromboembolism. Research evidences that IBD patients have about a 2- to 3-fold increase in the risk …

P331 Composite outcomes in Crohn’s disease: a systematic review and meta-analysis of observational studies Open

María Manuela Estevinho, Catarina Sottomayor, Cecília J. Alves, M Santago, Paula Ministro , et al. · 2022

Background Observational studies are essential to analyse outcome reporting in inflammatory bowel disease. However, such studies are usually heterogeneous. Therefore, the development of core outcome sets to be included in future observatio…

Composite outcomes in observational studies of ulcerative colitis: A systematic review and meta‐analysis Open

Fernando Magro, Catarina Alves, Mafalda Santiago, Paula Ministro, Paula Lago , et al. · 2021

Background Ulcerative colitis (UC) has been the focus of numerous observational studies over the years and a common strategy employed in their design is the use of composite and aggregate outcomes. Objective This systematic review and meta…

Thiopurines: Use them or lose them? International survey on current and future use of thiopurines in inflammatory bowel disease Open

Paula Sousa, Paula Ministro, Alessandro Armuzzi, Axel Dignaß, Marte Lie Høivik , et al. · 2021

P407 Thiopurines: use them or lose them? Results of an international survey Open

Paula Sousa, Paula Ministro, Alessandro Armuzzi, Axel Dignaß, Marte Lie Høivik , et al. · 2021

Background With the development of new drugs for inflammatory bowel disease (IBD), the role of thiopurines in the therapeutic algorithm of Crohn’s disease (CD) and Ulcerative Colitis (UC) is questioned. We aimed to investigate the current …

Age at Diagnosis Is Determinant for the Outcome of Inflammatory Bowel Disease: Is It a Myth? Open

Paula Ministro, Cláudia Camila Dias, Francisco Portela, Samuel Fernandes, Sónia Bernardo , et al. · 2021

INTRODUCTION: Patients with elderly-onset inflammatory bowel disease were previously associated with a less aggressive course of the disease. However, there are conflicting data that need further validation. We aimed to determine the assoc…

Clinical, Endoscopic and Histological Outcomes in Induction of Moderate-to-Severe Ulcerative Colitis: A Systematic Review with Meta-Analysis Open

Fernando Magro, María Manuela Estevinho, Cláudia Camila Dias, L Correia, Paula Lago , et al. · 2020

Background and Aims Interest in histology for ulcerative colitis [UC] has increased recently. This systematic review and meta-analysis aims to assess, for the first time, whether histological outcomes are more informative than endoscopic a…

Inflammatory Bowel Disease Reoperation Rate Has Decreased Over Time If Corrected by Prevalence Open

Mafalda Santiago, Fernando Magro, L Correia, Francisco Portela, Paula Ministro , et al. · 2020

INTRODUCTION: Despite the recent emergence of expensive biologic therapies, hospitalization and surgery remain important contributors for the overall costs of inflammatory bowel disease (IBD). In this study, we aimed to describe the burden…

Thiopurines’ Metabolites and Drug Toxicity: A Meta-Analysis Open

Paula Sousa, María Manuela Estevinho, Cláudia Camila Dias, Paula Ministro, Uri Kopylov , et al. · 2020

Many questions remain unanswered regarding therapeutic drug monitoring (TDM) utility with thiopurines. This study aims to establish a relationship between thiopurines’ metabolites and drug toxicity. We performed a systematic review with in…

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