Paula Muñoz Venturelli
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View article: Coupling Between Neural Oscillations and White Matter Integrity Reveals Cognitive Computational Profiles Following COVID-19
Coupling Between Neural Oscillations and White Matter Integrity Reveals Cognitive Computational Profiles Following COVID-19 Open
Persistent cognitive symptoms following SARS-CoV-2 infection have been widely reported, yet their underlying neural mechanisms remain poorly understood. Here, we applied an integrative framework—combining EEG, diffusion MRI, and computatio…
View article: Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study
Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study Open
View article: Intracerebral haemorrhage management practices and adherence to the INTERACT3 care bundle in Latin America: Results from an international survey
Intracerebral haemorrhage management practices and adherence to the INTERACT3 care bundle in Latin America: Results from an international survey Open
ICH management in Latin America is evolving, with increasing adoption of evidence-based practices. However, variability in adherence underscores the need for regional initiatives to standardize ICH care and ensure equitable implementation …
View article: Stroke and cervical artery dissection and/or aneurysm: 2019-2021 Chilean hospital-based national registry
Stroke and cervical artery dissection and/or aneurysm: 2019-2021 Chilean hospital-based national registry Open
In this Chilean hospital-based database, stroke occurrence among CeDA patients was linked to male sex, vertebral artery involvement, hypertension, current smoking, and atrial fibrillation. Further research is needed to understand the under…
View article: Stroke Burden Attributable to Risk Factors in the Americas, 1990–2021: A Temporal Trends Analysis from the Global Burden of Disease Study 2021
Stroke Burden Attributable to Risk Factors in the Americas, 1990–2021: A Temporal Trends Analysis from the Global Burden of Disease Study 2021 Open
Background Stroke remains a major public health concern with marked disparities across populations, particularly in the Americas. Despite documented declines in overall burden, limited data exist on how modifiable risk factors contribute t…
View article: Statistical analysis plan for the STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER) study: a randomised, open label, controlled trial in subjects with persistent neurological symptoms after COVID-19 infection
Statistical analysis plan for the STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER) study: a randomised, open label, controlled trial in subjects with persistent neurological symptoms after COVID-19 infection Open
We outline the statistical análysis plan (SAP) for the STatin TReatment for COVID-19 to Optimise NeuroloGical (STRONGER) study. STRONGER is an international, investigator-initiated and conducted, multicentre, prospective, randomised, open …
View article: STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection
STatin TReatment for COVID-19 to Optimise NeuroloGical recovERy (STRONGER): study protocol for a randomised, open label clinical trial in patients with persistent neurological symptoms after COVID-19 infection Open
Introduction Increasing awareness of the high frequency, wide spectrum and disabling nature of symptoms that can persist following COVID-19 infection has prompted the investigation of management strategies. Our study aims to determine the …
View article: Patient centered outcomes in stroke: utility-weighted modified Rankin Scale results in a community-based study
Patient centered outcomes in stroke: utility-weighted modified Rankin Scale results in a community-based study Open
Background and aims The transformation of modified Rankin Scale (mRS) scores based on the corresponding utilities of health-related quality of life questionnaires can facilitate the capture of Patient-Centered Outcomes (PCO) in stroke. We …
View article: Multimorbidity in acute ischemic stroke and its impact on short-term mortality: A Chilean nationwide database analysis
Multimorbidity in acute ischemic stroke and its impact on short-term mortality: A Chilean nationwide database analysis Open
Multimorbidity is common in patients with AIS and its components vary by age and sex. Cardiometabolic multimorbidity increases the likelihood of in-hospital mortality. Adopting a multimorbidity-focused approach to stroke care could improve…
View article: Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021
Risk and impact of stroke across 38 countries and territories of the Americas from 1990 to 2021: a population-based trends analysis from the Global Burden of Disease Study 2021 Open
There was no funding source for this study.
View article: Mapping Within-Country Disparities in Ischemic Stroke Burden and Trends by Human Development Index, Age and Sex
Mapping Within-Country Disparities in Ischemic Stroke Burden and Trends by Human Development Index, Age and Sex Open
View article: Surgical Outcomes from Haematoma Evacuation for Intracerebral Haemorrhage in the INTERACT3 Study
Surgical Outcomes from Haematoma Evacuation for Intracerebral Haemorrhage in the INTERACT3 Study Open
View article: The Main Optimal Post rTpa-Iv Monitoring in Ischaemic Stroke Trial (OPTIMISTmain): An International, Pragmatic, Stepped Wedge, Cluster Randomised, Controlled Non-Inferiority Trial
The Main Optimal Post rTpa-Iv Monitoring in Ischaemic Stroke Trial (OPTIMISTmain): An International, Pragmatic, Stepped Wedge, Cluster Randomised, Controlled Non-Inferiority Trial Open
View article: Implementing Low-Intensity Thrombolysis Monitoring for Patients with Acute Ischemic Stroke in Latin America: Insights from the Optimistmain Process Evaluation
Implementing Low-Intensity Thrombolysis Monitoring for Patients with Acute Ischemic Stroke in Latin America: Insights from the Optimistmain Process Evaluation Open
View article: Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial
Implementation of a goal-directed Care Bundle for intracerebral hemorrhage: Results of embedded process evaluation in the INTERACT3 trial Open
The third, stepped-wedge, cluster-randomized, Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3), has shown that a goal-directed multi-faceted Care Bundle incorporating protocols for the mana…
View article: Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST)
Statistical Analysis Plan for the Optimal Post rTpa-Iv Monitoring in Ischemic Stroke Trial (OPTIMIST) Open
1 Abstract The OPTIMIST trial aims to determine whether low-intensity monitoring is at least as effective (“non-inferior”) to standard monitoring, on the functional recovery of patients who have received recombinant tissue plasminogen acti…
View article: Clinical Profile of Stroke Chameleons Receiving Intravenous Thrombolysis: Insights from a Single-Center Experience
Clinical Profile of Stroke Chameleons Receiving Intravenous Thrombolysis: Insights from a Single-Center Experience Open
Introduction: In emergency rooms (ERs), 5% of patients experiencing an acute ischemic stroke (AIS) receive an alternative diagnosis; these cases are known as stroke chameleons (SC). The percentage of SC treated with intravenous thrombolysi…
View article: Predictive Accuracy of Clinicians Estimates of Death and Recovery after Acute Intracerebral Hemorrhage: Pre-Specified Analysis in INTERACT3 Study
Predictive Accuracy of Clinicians Estimates of Death and Recovery after Acute Intracerebral Hemorrhage: Pre-Specified Analysis in INTERACT3 Study Open
Introduction: Accurately predicting a patient’s prognosis is an important component of decision-making in intracerebral hemorrhage (ICH). We aimed to determine clinicians’ ability to predict survival, functional recovery, and return to pre…
View article: Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations
Patients recovering from COVID-19 who presented with anosmia during their acute episode have behavioral, functional, and structural brain alterations Open
Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors underlying these alterations remain elusive. Given the significant global incidence of COVID…
View article: Sex Differences in Profile and In‐Hospital Death for Acute Stroke in Chile: Data From a Nationwide Hospital Registry
Sex Differences in Profile and In‐Hospital Death for Acute Stroke in Chile: Data From a Nationwide Hospital Registry Open
Background Knowledge of local contextual sex differences in the profile and outcome for stroke can improve service delivery. We aimed to determine sex differences in the profile of patients with acute stroke and their associations with in‐…
View article: Recommendations for Implementing the INTERACT3 Care Bundle for Intracerebral Hemorrhage in Latin America: Results of a Delphi Method
Recommendations for Implementing the INTERACT3 Care Bundle for Intracerebral Hemorrhage in Latin America: Results of a Delphi Method Open
Introduction: The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3) showed that the implementation of a care bundle improves outcomes after acute intracerebral hemorrhage (ICH). We aim…
View article: Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome
Role of inflammation and evidence for the use of colchicine in patients with acute coronary syndrome Open
Acute Coronary Syndrome (ACS) significantly contributes to cardiovascular death worldwide. ACS may arise from the disruption of an atherosclerotic plaque, ultimately leading to acute ischemia and myocardial infarction. In the pathogenesis …
View article: Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends
Post-COVID-19 condition: a sex-based analysis of clinical and laboratory trends Open
Background and aim Post-COVID-19 condition (PCC) encompasses long-lasting symptoms in individuals with COVID-19 and is estimated to affect between 31–67% of patients, with women being more commonly affected. No definitive biomarkers have e…
View article: Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations
Patients Recovering from COVID-19 who Presented Anosmia During their Acute Episode have Behavioral, Functional, and Structural Brain Alterations Open
Patients recovering from COVID-19 commonly exhibit cognitive and brain alterations, yet the specific neuropathological mechanisms and risk factors that underlie these alterations remain elusive. Given the significant global incidence of CO…
View article: Recommendations for implementing the INTERACT3 care bundle for intracerebral hemorrhage in Latin America: a Delphi Study
Recommendations for implementing the INTERACT3 care bundle for intracerebral hemorrhage in Latin America: a Delphi Study Open
Background and aims The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT3) showed that the implementation of a care bundle improves outcomes after acute intracerebral hemorrhage (ICH). …
View article: The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial
The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with mild cognitive impairment in a Chilean sample: study protocol for a phase IIb, 2 × 3 mixed factorial, double-blind randomised controlled trial Open
Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as dementia and mild cognitive impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage …
View article: The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with Mild Cognitive Impairment in a Chilean sample: study protocol for a randomised controlled trial
The effect of a cognitive training therapy based on stimulation of brain oscillations in patients with Mild Cognitive Impairment in a Chilean sample: study protocol for a randomised controlled trial Open
Background The ageing population has increased the prevalence of disabling and high-cost diseases, such as Dementia and Mild Cognitive Impairment (MCI). The latter can be considered a prodromal phase of some dementias and a critical stage …
View article: Burden of Stroke Across 38 Countries and Territories of the Americas from 1990 to 2021: A Population-Based Trends Analysis from the Global Burden of Disease Study 2021
Burden of Stroke Across 38 Countries and Territories of the Americas from 1990 to 2021: A Population-Based Trends Analysis from the Global Burden of Disease Study 2021 Open
View article: Sex differences in profile and in-hospital mortality for acute stroke in Chile: data from a nationwide hospital registry
Sex differences in profile and in-hospital mortality for acute stroke in Chile: data from a nationwide hospital registry Open
Background Knowledge of local contextual sex-differences in the profile and outcome for stroke can improve service delivery. We aimed to determine sex-differences in the profile of patients with acute stroke and their associations with in-…
View article: Dilated optic nerve sheath by ultrasound predicts mortality among patients with acute intracerebral hemorrhage
Dilated optic nerve sheath by ultrasound predicts mortality among patients with acute intracerebral hemorrhage Open
Background Intracerebral hemorrhage (ICH) is a deadly disease and increased intracranial pressure (ICP) is associated with worse outcomes in this context. Objective We evaluated whether dilated optic nerve sheath diameter (ONSD) depicted b…