Paula V. Subirada
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View article: Corrigendum to “Nitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy” [Redox Biol. 83 (2025) 103634]
Corrigendum to “Nitro-Oleic acid protects from neovascularization, oxidative stress, gliosis and neurodegeneration in oxygen-induced retinopathy” [Redox Biol. 83 (2025) 103634] Open
View article: Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo
Doxycycline inhibits MMP-2 retinal activity and modulates the angiogenic process in vitro and in vivo Open
Introduction Vascular endothelial growth factor (VEGF) inhibition is currently the first-line therapy for various retinal vascular disorders, however there is a strong need to develop novel therapies to target other molecules involved in t…
View article: Protective Effect of NO2-OA on Oxidative Stress, Gliosis, and Pro-Angiogenic Response in Müller Glial Cells
Protective Effect of NO2-OA on Oxidative Stress, Gliosis, and Pro-Angiogenic Response in Müller Glial Cells Open
Inflammation and oxidative and nitrosative stress are involved in the pathogenesis of proliferative retinopathies (PR). In PR, a loss of balance between pro-angiogenic and anti-angiogenic factors favors the secretion of vascular endothelia…
View article: Etiological Roles of p75NTR in a Mouse Model of Wet Age-Related Macular Degeneration
Etiological Roles of p75NTR in a Mouse Model of Wet Age-Related Macular Degeneration Open
Choroidal neovascularization (CNV) is a pathological angiogenesis of the choroidal plexus of the retina and is a key feature in the wet form of age-related macular degeneration. Mononuclear phagocytic cells (MPCs) are known to accumulate i…
View article: Rapamycin and Resveratrol Modulate the Gliotic and Pro-Angiogenic Response in Müller Glial Cells Under Hypoxia
Rapamycin and Resveratrol Modulate the Gliotic and Pro-Angiogenic Response in Müller Glial Cells Under Hypoxia Open
Hypoxia and hypoxia-reoxygenation are frequently developed through the course of many retinal diseases of different etiologies. Müller glial cells (MGCs), together with microglia and astrocytes, participate firstly in response to the injur…
View article: Triiodothyronine-Stimulated Dendritic Cell Vaccination Boosts Antitumor Immunity Against Murine Colon Cancer
Triiodothyronine-Stimulated Dendritic Cell Vaccination Boosts Antitumor Immunity Against Murine Colon Cancer Open
View article: Metabolic Syndrome Triggered by Fructose Diet Impairs Neuronal Function and Vascular Integrity in ApoE-KO Mouse Retinas: Implications of Autophagy Deficient Activation
Metabolic Syndrome Triggered by Fructose Diet Impairs Neuronal Function and Vascular Integrity in ApoE-KO Mouse Retinas: Implications of Autophagy Deficient Activation Open
Metabolic syndrome is a disorder characterized by a constellation of clinical findings such as elevated blood glucose, hyperinsulinemia, dyslipidemia, hypertension, and obesity. A positive correlation has been found between metabolic syndr…
View article: VALIDATION OF LASER-INDUCED CHOROIDAL NEOVASCULARIZATION (CNV) MOUSE MODEL: PARTICIPATION OF α2M/LRP1 SYSTEM
VALIDATION OF LASER-INDUCED CHOROIDAL NEOVASCULARIZATION (CNV) MOUSE MODEL: PARTICIPATION OF α2M/LRP1 SYSTEM Open
View article: Effect of nitro-oleic acid on the oxidative stress and glial reactivity in Müller Glial Cells
Effect of nitro-oleic acid on the oxidative stress and glial reactivity in Müller Glial Cells Open
View article: Effect of Autophagy Modulators on Vascular, Glial, and Neuronal Alterations in the Oxygen-Induced Retinopathy Mouse Model
Effect of Autophagy Modulators on Vascular, Glial, and Neuronal Alterations in the Oxygen-Induced Retinopathy Mouse Model Open
Hypoxia is one of the main insults in proliferative retinopathies, leading to neovascularization and neurodegeneration. To maintain homeostasis, neurons require efficient degradation and recycling systems. Autophagy participates in retinal…
View article: NEOVASCULAR RETINOPATHIES: ETIOLOGY AND MODELS OF STUDY FOR SEARCHING NEW THERAPEUTIC TARGETS
NEOVASCULAR RETINOPATHIES: ETIOLOGY AND MODELS OF STUDY FOR SEARCHING NEW THERAPEUTIC TARGETS Open
Las retinopatías neovasculares se encuentran dentro de las principales causas de ceguera. En estas patologías, el déficit visual es causado en parte por un desbalance de factores angiogénicos posterior a un evento isquémico, que provoca la…
View article: Comparative study of VEGF inhibitors in Oxygen Induced Retinopathy (OIR) mouse model: Vascular, non-vascular and functional implications
Comparative study of VEGF inhibitors in Oxygen Induced Retinopathy (OIR) mouse model: Vascular, non-vascular and functional implications Open
View article: A journey into the retina: Müller glia commanding survival and death
A journey into the retina: Müller glia commanding survival and death Open
Müller glial cells ( MGC s) are known to participate actively in retinal development and to contribute to homoeostasis through many intracellular mechanisms. As there are no homologous cells in other neuronal tissues, it is certain that re…
View article: Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF
Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF Open
Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is stil…
View article: Non-vascular alterations and functional impairment persist after Anti-VEGF therapy in Oxygen Induced Retinopathy (OIR) mouse model
Non-vascular alterations and functional impairment persist after Anti-VEGF therapy in Oxygen Induced Retinopathy (OIR) mouse model Open