Paula Virkkula
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View article: Efficacy of Aspirin Therapy After Desensitization on Chronic Rhinosinusitis With Nasal Polyps Patients With Asthma and Non‐steroidal Anti‐inflammatory Drug Exacerbated Respiratory Disease —A Randomized Clinical Trial
Efficacy of Aspirin Therapy After Desensitization on Chronic Rhinosinusitis With Nasal Polyps Patients With Asthma and Non‐steroidal Anti‐inflammatory Drug Exacerbated Respiratory Disease —A Randomized Clinical Trial Open
Non‐steroidal anti‐inflammatory drug (NSAID) exacerbated respiratory disease (N‐ERD) is a chronic inflammatory condition typically involving hypersensitivity to NSAIDs, asthma, and/or chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP)…
View article: Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory disease, and asthma
Study protocol for a randomized double-blinded placebo-controlled trial on ASA therapy for patients with chronic rhinosinusitis with nasal polyps, NSAID-exacerbated respiratory disease, and asthma Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory condition affecting the nasal passages and paranasal sinuses. It is characterized by persistent inflammation and often leads to a considerable decline i…
View article: Radiological score, asthma and NSAID‐exacerbated respiratory disease predict relapsing chronic rhinosinusitis
Radiological score, asthma and NSAID‐exacerbated respiratory disease predict relapsing chronic rhinosinusitis Open
Objectives The aim was to evaluate the predictive potential of Sinonasal Radiological (SR) and the Lund‐Mackay (LM) score of sinus computed tomography (CT) scans on postoperative relapses of chronic rhinosinusitis (CRS). Materials and Meth…
View article: Study protocol for a randomized double-blinded placebo-controlled trial on mepolizumab for patients with chronic rhinosinusitis with nasal polyps, NSAID exacerbated respiratory disease and asthma
Study protocol for a randomized double-blinded placebo-controlled trial on mepolizumab for patients with chronic rhinosinusitis with nasal polyps, NSAID exacerbated respiratory disease and asthma Open
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease of the nose and paranasal sinuses that significantly impactshealth-related quality of life. Nonsteroidal anti-inflammatory drug (NSAID) -exacerbated re…
View article: Asthma is Underdiagnosed and Often Uncontrolled in Preoperative Patients With Chronic Rhinosinusitis With Nasal Polyps
Asthma is Underdiagnosed and Often Uncontrolled in Preoperative Patients With Chronic Rhinosinusitis With Nasal Polyps Open
Most patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have type 2 inflammation, as do patients with eosinophilic asthma [1-3]. Asthma often accompanies CRSwNP [4, 5], and CRSwNP with comorbid asthma is associated with more s…
View article: Chronic Rhinosinusitis Outcome Registry (CHRINOSOR): Establishment of an International Outcome Registry Driven by mHealth Technology
Chronic Rhinosinusitis Outcome Registry (CHRINOSOR): Establishment of an International Outcome Registry Driven by mHealth Technology Open
View article: The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden
The relative proportion of comorbidities among rhinitis and rhinosinusitis patients and their impact on visit burden Open
Background The aim was to evaluate the relative proportion of Non‐steroidal anti‐inflammatory drug exacerbated respiratory disease (NERD) and other comorbidities, and their impact on the burden of outpatient visits due to allergic rhinitis…
View article: Using machine learning for the personalised prediction of revision endoscopic sinus surgery
Using machine learning for the personalised prediction of revision endoscopic sinus surgery Open
Background Revision endoscopic sinus surgery (ESS) is often considered for chronic rhinosinusitis (CRS) if maximal conservative treatment and baseline ESS prove insufficient. Emerging research outlines the risk factors of revision ESS. How…
View article: Do aggravating rhinologic symptoms at work indicate occupational exposure? A cross-sectional outpatient clinic study
Do aggravating rhinologic symptoms at work indicate occupational exposure? A cross-sectional outpatient clinic study Open
Exposure to specific occupational sensitizers or irritants did not associate with increasing symptoms at work or quality of life amongst our patients. Most rhinology patients reported exacerbated symptoms at work. They appeared to be more …
View article: The extent of endoscopic sinus surgery in patients with severe chronic rhinosinusitis with nasal polyps (AirGOs Operative)
The extent of endoscopic sinus surgery in patients with severe chronic rhinosinusitis with nasal polyps (AirGOs Operative) Open
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the nose and paranasal sinuses characterized by intense inflammation, decreased health-related quality of life (HRQoL), and in severe cases …
View article: Using machine learning for personalized prediction of revision paranasal sinus surgery
Using machine learning for personalized prediction of revision paranasal sinus surgery Open
Background: Uncontrolled chronic rhinosinusitis (CRS) needing consideration of surgery is a growing health problem yet its risk factors at individual level are not known. Our aim was to examine risk factors of revision endoscopic sinus sur…
View article: Seasonal Variation in Generic and Disease-Specific Health-Related Quality of Life in Rhinologic Patients in Southern Finland
Seasonal Variation in Generic and Disease-Specific Health-Related Quality of Life in Rhinologic Patients in Southern Finland Open
Background: Seasonal variation in exacerbations, hospitalisations, and mortality statistics has been reported for some diseases. To our knowledge, however, no published studies exist on the seasonality of health-related quality of life (HR…
View article: Factors Affecting the Control of Chronic Rhinosinusitis With Nasal Polyps: A Comparison in Patients With or Without NERD
Factors Affecting the Control of Chronic Rhinosinusitis With Nasal Polyps: A Comparison in Patients With or Without NERD Open
Objectives The aim was to compare the control of chronic rhinosinusitis with nasal polyps (CRSwNP) after endoscopic sinus surgery (ESS), in patients with/without nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). S…
View article: Translation, cross-cultural adaptation, and validation of the sino-nasal outcome test (snot)-22 for Finnish patients
Translation, cross-cultural adaptation, and validation of the sino-nasal outcome test (snot)-22 for Finnish patients Open
View article: Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study
Assessing Cut-off Points of Eosinophils, Nasal Polyp, and Lund-Mackay Scores to Predict Surgery in Nasal Polyposis: A Real-World Study Open
Background Developing tools to identify chronic rhinosinusitis with nasal polyps (CRSwNP) patients requiring surgical treatment would help clinicians treat patients more effectively. The aim of this retrospective cross-sectional study was …
View article: Practical Aspects of Interface Application in CPAP Treatment
Practical Aspects of Interface Application in CPAP Treatment Open
While continuous positive airway pressure (CPAP) is an effective first-line therapy for sleep apnea, CPAP fails in one third of patients mainly due to poor adherence to the CPAP device and masks. The role of the medical team is to guide th…
View article: EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis
EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis Open
The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collab…
View article: EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis
EUFOREA Rhinology Research Forum 2016: report of the brainstorming sessions on needs and priorities in rhinitis and rhinosinusitis Open
The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collab…
View article: Tautikohtaisen elämänlaatumittarin validointi : esimerkkinä nenä- ja sivuontelotautikohtainen SNOT-22-mittari
Tautikohtaisen elämänlaatumittarin validointi : esimerkkinä nenä- ja sivuontelotautikohtainen SNOT-22-mittari Open
JOHDANTO. Kehitettäessä hoidon vaikuttavuusmittaria voidaan joko tehdä uusi tai validoida aiemmin julkaistu mittari. Tutkimuksessamme validoitiin Sino-Nasal Outcome Test-22 suomeksi.
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\nMENETELMÄT. SNOT-22 sisältää kysymyksiä, joihin vas…
View article: Surgical Outcome and Complications of Nasal Septal Perforation Repair with Temporal Fascia and Periosteal Grafts
Surgical Outcome and Complications of Nasal Septal Perforation Repair with Temporal Fascia and Periosteal Grafts Open
Aims Surgical treatment of nasal septal perforation remains a challenging field of rhinology. A large variety of techniques and grafts with promising results have been introduced for perforation repair. However, the use of fascia or fascia…
View article: How Patients Experience Antral Irrigation
How Patients Experience Antral Irrigation Open
Background Antral irrigation earlier had an important role in the diagnosis and treatment of rhinosinusitis. Nowadays, it is often considered too unpleasant. However, the experience of patients of this procedure has been very seldom evalua…