Paulina Jedynak
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View article: Prenatal Exposure to Synthetic Phenols Assessed in Multiple Urine Samples and Dysregulation of Steroid Hormone Homeostasis in Two European Cohorts
Prenatal Exposure to Synthetic Phenols Assessed in Multiple Urine Samples and Dysregulation of Steroid Hormone Homeostasis in Two European Cohorts Open
Our study suggests that pregnancy exposure to bisphenol S and some parabens (propyl- and methylparaben) may affect production of maternal corticosteroid hormones that are important for a successful pregnancy and fetal development. https://…
View article: Expositions environnementales et modifications de l’épigénome dans la période des 1000 premiers jours de vie
Expositions environnementales et modifications de l’épigénome dans la période des 1000 premiers jours de vie Open
Les expositions environnementales précoces peuvent influencer le développement et la santé de l’enfant à long terme. Des modifications épigénétiques pourraient partiellement expliquer ces effets, et leur identification conduire à des progr…
View article: Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates
Epigenetic footprints: Investigating placental DNA methylation in the context of prenatal exposure to phenols and phthalates Open
View article: Cohort Profile: Barcelona Life Study Cohort (BiSC)
Cohort Profile: Barcelona Life Study Cohort (BiSC) Open
This work was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (785994—AirNB project) and the Health Effects Institute (HEI), an organization jointly funded by the U…
View article: Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection
Analyzing the impact of phthalate and DINCH exposure on fetal growth in a cohort with repeated urine collection Open
In this pregnancy cohort using repeated urine samples to assess exposure, MiBP and MnBP were associated with increased fetal growth parameters. Further investigation on the effects of phthalates on child health would be relevant for expand…
View article: Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort
Longitudinal Associations between Prenatal Exposure to Phthalates and Steroid Hormones in Maternal Hair Samples from the SEPAGES Cohort Open
We assessed phthalate-hormone associations in 382 pregnant women of the new-generation SEPAGES cohort (2014-2017, France) using improved exposure and outcome assessments. Metabolites from seven phthalate compounds and the replacement di(is…
View article: Prenatal exposure to phthalates and fetal growth in the SEPAGES cohort relying on repeated urine collection
Prenatal exposure to phthalates and fetal growth in the SEPAGES cohort relying on repeated urine collection Open
International audience
View article: Prenatal exposure to triclosan assessed in multiple urine samples and placental DNA methylation
Prenatal exposure to triclosan assessed in multiple urine samples and placental DNA methylation Open
View article: Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review
Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: A scoping review Open
View article: Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: a scoping review
Integrating -omics approaches into population-based studies of endocrine disrupting chemicals: a scoping review Open
Health effects of endocrine disrupting chemicals (EDCs) are challenging to detect in the general population. Omics technologies become increasingly common to identify early biological changes before the apparition of clinical symptoms, to …
View article: Omics associations with non-persistent endocrine-disrupting chemicals (EDCs) exposure in humans: a scoping review
Omics associations with non-persistent endocrine-disrupting chemicals (EDCs) exposure in humans: a scoping review Open
Health effects of non-persistent EDCs, characterised by short half-lives and fast metabolism, are challenging to be detected in the general population due to EDC intra-individual variability, general ubiquity and latent effects. Omics are …
View article: Prenatal exposure to triclosan assessed through repeated urine samples and placental DNA methylation in the SEPAGES cohort
Prenatal exposure to triclosan assessed through repeated urine samples and placental DNA methylation in the SEPAGES cohort Open
Background: Previously we showed associations between elevated maternal urinary concentrations of triclosan in French pregnant women and increased placental DNA methylation in male fetuses, an effect potentially mediated by placental cell …
View article: Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth
Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth Open
Background: Some synthetic phenols alter pathways involved in fetal development. Despite their high within-subject temporal variability, earlier studies relied on spot urine samples to assess pregnancy exposure. In this study, we examined …
View article: Pregnancy exposure to phthalates and DNA methylation in male placenta — An epigenome-wide association study
Pregnancy exposure to phthalates and DNA methylation in male placenta — An epigenome-wide association study Open
View article: DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification
DECONbench: a benchmarking platform dedicated to deconvolution methods for tumor heterogeneity quantification Open
View article: Pregnancy exposure to phthalates and placental DNA methylation in the French EDEN cohort
Pregnancy exposure to phthalates and placental DNA methylation in the French EDEN cohort Open
International audience
View article: Pregnancy exposure to synthetic phenols and placental DNA methylation — An epigenome-wide association study in male infants from the EDEN cohort
Pregnancy exposure to synthetic phenols and placental DNA methylation — An epigenome-wide association study in male infants from the EDEN cohort Open
In utero exposure to environmental chemicals, such as synthetic phenols, may alter DNA methylation in different tissues, including placenta - a critical organ for fetal development. We studied associations between prenatal urinary biomarke…
View article: Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts
Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age – An exposome-based approach in 5 European cohorts Open
View article: Prenatal exposure to environmental contaminants and child behaviour between 3 to 7 years, an exposome-based approach on 5 European cohorts
Prenatal exposure to environmental contaminants and child behaviour between 3 to 7 years, an exposome-based approach on 5 European cohorts Open
International audience
View article: Prenatal exposure to environmental contaminants and child behaviour in the HELIX european cohorts
Prenatal exposure to environmental contaminants and child behaviour in the HELIX european cohorts Open
The focus of this study was to assess the associations between prenatal exposure to a wide range of environmental chemicals, including some that have been identified as neurodevelopmental disruptors, and child externalising and internalisi…
View article: Manipulation of CREB related gene expression in neurons influences adult neurogenesis and morris water maze strategies
Manipulation of CREB related gene expression in neurons influences adult neurogenesis and morris water maze strategies Open
View article: HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder
HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder Open
Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase predominantly expressed in the brain. Mutations of the CDKL5 gene lead to CDKL5 disorder, a neurodevelopmental pathology that shares several features with Rett Syndrome and…
View article: Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats
Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats Open
There was an error published in Dis. Model. Mech. 8, 1323-1337.An erroneous TaqMan assay was used to evaluate the expression of the PSD-95 gene by RT-PCR. Therefore, the data shown in Fig. 7I do not represent the expression levels of the P…
View article: Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats.
Transient alteration of the vestibular calyceal junction and synapse in response to chronic ototoxic insult in rats. Open
Ototoxicity is known to cause permanent loss of vestibule function through degeneration of sensory hair cells (HCs). However, functional recovery has been reported at times during washout after chronic ototoxicity, although the mechanisms …