Pauline MW van Kempen
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View article: Promoter hypermethylation using 24-gene array in early head and neck cancer
Promoter hypermethylation using 24-gene array in early head and neck cancer Open
Silencing of tumor suppressor genes (TSGs) by DNA promoter hypermethylation is an early event in carcinogenesis and a potential target for personalized cancer treatment. In head and neck cancer, little is known about the role of promoter h…
View article: Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma
Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma Open
Oropharyngeal squamous cell carcinoma (OPSCC) is associated with human papillomavirus (HPV). HPV-positive OPSCC is considered a distinct molecular entity with a better prognosis than HPV-negative cases of OPSCC. However, the exact pathogen…