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View article: Liquid-crystalline pillar[5]arene-based [2]rotaxanes
Liquid-crystalline pillar[5]arene-based [2]rotaxanes Open
Liquid-crystalline mechanically interlocked molecules have been prepared from a clickable pillar[5]arene-containing [2]rotaxane building block incorporating ethynylated stoppers and dendritic mesogenic subunits of generation 0, 1 and 2 und…
View article: Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis
Biological activity and structure–activity relationship of dehydrodieugenol B analogues against visceral leishmaniasis Open
39 synthetic compounds based on the core scaffold of the neoligan dehydrodieugenol B presented activity against intracellular amastigotes of Leishmania .
View article: Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria
Marine alkaloids as bioactive agents against protozoal neglected tropical diseases and malaria Open
This Review discusses the isolation and bioactivity of marine alkaloids against protozoan parasite diseases, and chemical syntheses that enable the further development of these scaffolds as drug leads.
View article: Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against <i>Trypanosoma cruzi</i>
Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against <i>Trypanosoma cruzi</i> Open
Trypanosoma cruzi is the etiologic agent of Chagas disease, which affects over seven million people, especially in developing countries. Undesirable side effects are frequently associated with current therapies, which are typically ineffec…
View article: CCDC 1570801: Experimental Crystal Structure Determination
CCDC 1570801: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Olefin Cross‐Metathesis: a Versatile Synthetic Reaction for the Design of <i>Janus</i> Liquid Crystals
Olefin Cross‐Metathesis: a Versatile Synthetic Reaction for the Design of <i>Janus</i> Liquid Crystals Open
The olefin cross‐metathesis reaction using the second‐generation Grubbs catalyst was employed to prepare non‐symmetrical thermotropic liquid crystals from various mesomorphic or nonmesomorphic type I and type II olefinic constructs, includ…