Pauline Tarot
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View article: Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer
Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer Open
Membrane contact sites harbor a distinct set of proteins with varying biological functions, thereby emerging as hubs for localized signaling nanodomains underlying adequate cell function. Here, we will focus on mitochondria-associated endo…
View article: NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality
NRF2 signaling cascade in amyotrophic lateral sclerosis: bridging the gap between promise and reality Open
Amyotrophic lateral sclerosis is a very disabling disease due to the degeneration of motor neurons. Symptoms include muscle weakness and atrophy, spasticity, and progressive paralysis. Currently, there is no treatment to reverse damage to …
View article: Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors
Dopamine D2 receptors in the extended amygdala scale the optimization of seeking and avoidance behaviors Open
In mammals, the ability to optimize and select behavioral strategies is a cardinal and conserved psychophysiological feature for maximizing the chances of survival. However, the neural circuits and underlying mechanisms regulating this fle…
View article: Psychostimulant Drugs Activate Cell-type Specific and Topographic cFos Expression in the Lumbar Spinal Cord
Psychostimulant Drugs Activate Cell-type Specific and Topographic cFos Expression in the Lumbar Spinal Cord Open
View article: Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling
Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling Open
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting upper and lower motor neurons. As a consequence, ALS patients display a locomotor disorder related to muscle weakness and progressive paralysis. Pathological mech…
View article: Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors
Selection of active defensive behaviors relies on extended amygdala dopamine D2 receptors Open
Summary The ability to efficiently switch from one defensive strategy to another maximizes an animal’s chance of survival. Here, we demonstrate that the selection of active defensive behaviors requires the coordinated activation of dopamin…
View article: Regulation of GluA1 phosphorylation by <i>d</i> ‐amphetamine and methylphenidate in the cerebellum
Regulation of GluA1 phosphorylation by <i>d</i> ‐amphetamine and methylphenidate in the cerebellum Open
Prescription stimulants, such as d ‐amphetamine or methylphenidate are used to treat suffering from attention‐deficit hyperactivity disorder (ADHD). They potently release dopamine (DA) and norepinephrine (NE) and cause phosphorylation of t…
View article: Regulation of GluA1 Phosphorylation by D-amphetamine and Methylphenidate in the Cerebellum
Regulation of GluA1 Phosphorylation by D-amphetamine and Methylphenidate in the Cerebellum Open
Prescription stimulants, such as d-amphetamine or methylphenidate, are potent dopamine (DA) and norepinephrine (NE) releasers used to treat children and adults diagnosed for attention-deficit/hyperactivity disorder (ADHD). Although increas…
View article: Cerebellar dopamine D2 receptors regulate preference for social novelty
Cerebellar dopamine D2 receptors regulate preference for social novelty Open
Summary The cerebellum, a primary center involved in the control of sensorimotor tasks, also contributes to higher cognitive functions including reward, emotion and social interaction. The regulation of these behaviors has been largely asc…
View article: Characterization anatomo-functional of D2 dopamine receptor (D2R)-containing cell in the mouse spinal cord
Characterization anatomo-functional of D2 dopamine receptor (D2R)-containing cell in the mouse spinal cord Open
La moelle spinale est un relais majeur permettant aux informations sensorielles perçues à la périphérie d’être transférées et intégrées au niveau des centres supra-spinaux. Les afférences primaires somatosensorielles vont arriver au niveau…
View article: Caractérisation anatomo-fonctionnelle des cellules exprimant les récepteurs D2 à la dopamine (D2R) dans la moelle spinale de souris
Caractérisation anatomo-fonctionnelle des cellules exprimant les récepteurs D2 à la dopamine (D2R) dans la moelle spinale de souris Open
The spinal cord is the major relay station for sensory information generated at the periphery and transferred for processing to the brain. Sensitive primary afferent fibers arrive to the dorsal horn that is populated by a vast diversity of…
View article: Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals
Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals Open
The caudal part of the striatum, also named the tail of the striatum (TS), defines a fourth striatal domain. Determining whether rewarding, aversive and salient stimuli regulate the activity of striatal spiny projections neurons (SPNs) of …
View article: Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals
Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals Open
The caudal part of the striatum, also named the tail of the striatum (TS), defines a fourth striatal domain. Determining whether rewarding, aversive and salient stimuli regulate the activity of striatal spiny projections neurons (SPNs) of …