Pauline W. Wang
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View article: Mother’s milk microbiota is associated with the developing gut microbial consortia in very-low-birth-weight infants
Mother’s milk microbiota is associated with the developing gut microbial consortia in very-low-birth-weight infants Open
View article: Chromosome-Scale Assembly and Annotation of Eight <i>Arabidopsis thaliana</i> Ecotypes
Chromosome-Scale Assembly and Annotation of Eight <i>Arabidopsis thaliana</i> Ecotypes Open
The plant Arabidopsis thaliana is a model system used by researchers through much of plant research. Recent efforts have focused on discovering the genomic variation found in naturally occurring ecotypes isolated from around the world. The…
View article: The effector-triggered immunity landscape of tomato against Pseudomonas syringae
The effector-triggered immunity landscape of tomato against Pseudomonas syringae Open
View article: The impact of gestational diabetes on functional capacity of the infant gut microbiome is modest and transient
The impact of gestational diabetes on functional capacity of the infant gut microbiome is modest and transient Open
Gestational diabetes mellitus (GDM) is a metabolic complication that manifests as hyperglycemia during the later stages of pregnancy. In high resource settings, careful management of GDM limits risk to the pregnancy, and hyperglycemia typi…
View article: <i>Pseudomonas syringae</i> coffee blight is associated with the horizontal transfer of plasmid‐encoded type III effectors
<i>Pseudomonas syringae</i> coffee blight is associated with the horizontal transfer of plasmid‐encoded type III effectors Open
Summary The emergence of new pathogens is an ongoing threat to human health and agriculture. While zoonotic spillovers received considerable attention, the emergence of crop diseases is less well studied. Here, we identify genomic factors …
View article: The impact of gestational diabetes on functional capacity of the infant gut microbiome is modest and transient
The impact of gestational diabetes on functional capacity of the infant gut microbiome is modest and transient Open
Gestational diabetes mellitus (GDM) is a metabolic complication that manifests as hyperglycemia during the later stages of pregnancy. In high resource settings, careful management of GDM limits risk to the pregnancy, and hyperglycemia typi…
View article: Predictive modeling of antibiotic eradication therapy success for new-onset Pseudomonas aeruginosa pulmonary infections in children with cystic fibrosis
Predictive modeling of antibiotic eradication therapy success for new-onset Pseudomonas aeruginosa pulmonary infections in children with cystic fibrosis Open
Chronic Pseudomonas aeruginosa (Pa) lung infections are the leading cause of mortality among cystic fibrosis (CF) patients; therefore, the eradication of new-onset Pa lung infections is an important therapeutic goal that can have long-term…
View article: Detection of Covid-19 Outbreaks Using Built Environment Testing for SARS-CoV-2
Detection of Covid-19 Outbreaks Using Built Environment Testing for SARS-CoV-2 Open
BACKGROUND: Environmental surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through wastewater has become a useful tool for population-level surveillance. Built environment sampling may provide a more spatially r…
View article: Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis
Pseudomonas aeruginosa aggregation and Psl expression in sputum is associated with antibiotic eradication failure in children with cystic fibrosis Open
View article: Habitats Within the Plant Root Differ in Bacterial Network Topology and Taxonomic Assortativity
Habitats Within the Plant Root Differ in Bacterial Network Topology and Taxonomic Assortativity Open
The root microbiome is composed of distinct epiphytic (rhizosphere) and endophytic (endosphere) habitats. Differences in abiotic and biotic factors drive differences in microbial community diversity and composition between these habitats, …
View article: Cooperative virulence via the collective action of secreted pathogen effectors
Cooperative virulence via the collective action of secreted pathogen effectors Open
Barcode sequence data. Unique barcode sequences were incorporated into the effector plasmids to confirm that all individual effector clones within the metaclone were present throughout infection and that the overall diversity of the metacl…
View article: Predictive modeling of antibiotic eradication therapy success for new-onset<i>Pseudomonas aeruginosa</i>pulmonary infections in children with cystic fibrosis
Predictive modeling of antibiotic eradication therapy success for new-onset<i>Pseudomonas aeruginosa</i>pulmonary infections in children with cystic fibrosis Open
Chronic Pseudomonas aeruginosa (Pa) lung infections are the leading cause of mortality among cystic fibrosis (CF) patients; therefore, the eradication of new-onset Pa lung infections is an important therapeutic goal that can have long-term…
View article: Cooperative virulence via the collective action of secreted pathogen effectors
Cooperative virulence via the collective action of secreted pathogen effectors Open
Barcode sequence data. Unique barcode sequences were incorporated into the effector plasmids to confirm that all individual effector clones within the metaclone were present throughout infection and that the overall diversity of the metacl…
View article: Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Background The emergence of antimicrobial resistance is a major threat to global health and has placed pressure on the livestock industry to eliminate the use of antibiotic growth promotants (AGPs) as feed additives. To mitigate their remo…
View article: Predictive modeling of Pseudomonas syringae virulence on bean using gradient boosted decision trees
Predictive modeling of Pseudomonas syringae virulence on bean using gradient boosted decision trees Open
Pseudomonas syringae is a genetically diverse bacterial species complex responsible for numerous agronomically important crop diseases. Individual P . syringae isolates are assigned pathovar designations based on their host of isolation an…
View article: Detection of COVID-19 Outbreaks in Long-Term Care Homes Using Built Environment Testing for SARS-CoV-2: A Multicentre Prospective Study
Detection of COVID-19 Outbreaks in Long-Term Care Homes Using Built Environment Testing for SARS-CoV-2: A Multicentre Prospective Study Open
Background Environmental surveillance of SARS-CoV-2 via wastewater has become an invaluable tool for population-level surveillance of COVID-19. Built environment sampling may provide a more spatially refined approach for surveillance of CO…
View article: Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae
Metaeffector interactions modulate the type III effector-triggered immunity load of Pseudomonas syringae Open
The bacterial plant pathogen Pseudomonas syringae requires type III secreted effectors (T3SEs) for pathogenesis. However, a major facet of plant immunity entails the recognition of a subset of P . syringae ’s T3SEs by intracellular host re…
View article: Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses
Immunoglobulin A nephropathy is characterized by anticommensal humoral immune responses Open
IgA nephropathy (IgAN) is a leading cause of kidney failure, yet little is known about the immunopathogenesis of this disease. IgAN is characterized by deposition of IgA in the kidney glomeruli, but the source and stimulus for IgA producti…
View article: The emergence of virulence via the collective action of bacterial effectors
The emergence of virulence via the collective action of bacterial effectors Open
Eukaryotes continuously interact with diverse microbial populations and communities, forming relationships spanning a continuum from beneficial to pathogenic. Pathogenic effectors are central to these associations since they directly targe…
View article: Additional file 21 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 21 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 21: Supplemental Table 8. Transcripts expressed in the ceca exhibiting significant differential expression between AGPs and diets.
View article: Additional file 15 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 15 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 15: Supplemental Table 2. Details of Samples and 16S Survey Sequencing Statistics.
View article: Additional file 25 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 25 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 25: Supplemental Table 12. Metabolite profiles of serum samples collected from all 60 birds used in the study. Supplemental Table 12 Metabolite profiles of serum samples collected from all 60 birds used in the study.
View article: Additional file 26 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 26 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 26: Supplemental Table 13. Expression of transcripts (RPKM) associated with antimicrobial resistance mechanisms across cecal samples.
View article: Additional file 17 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 17 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 17: Supplemental Table 4. Abundance of Taxa in Cecal Samples Exhibiting Significant Changes in Abundance Across Different Treatments.
View article: Additional file 27 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 27 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 27: Supplemental Table 14. Expression of transcripts (RPKM) associated with antimicrobial resistance mechanisms across jejunum samples.
View article: Additional file 24 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 24 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 24: Supplemental Table 11. List of Abbreviations of Compounds and Enzymes.
View article: Additional file 19 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 19 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 19: Supplemental Table 6. List of bacterial transcripts and their relative expression (RPKM) across all samples.
View article: Additional file 20 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 20 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 20: Supplemental Table 7. Main and Interaction Effects of Diet and AGPs on Gene Expression for Day24 and Day40 Cecal Samples.
View article: Additional file 18 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 18 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 18: Supplemental Table 5. Details of Metatranscriptome Sequencing Statistics.
View article: Additional file 23 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure
Additional file 23 of Systematic profiling of the chicken gut microbiome reveals dietary supplementation with antibiotics alters expression of multiple microbial pathways with minimal impact on community structure Open
Additional file 23: Supplemental Table 10. Enzymes detected in 73 metatranscriptomic datasets.