Paulo Pinares-Garcia
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View article: 683. GHRELIN RECEPTOR SIGNALLING IN THE EDINGER-WESTPHAL NUCLEUS REGULATES BINGE DRINKING IN A SEX-SPECIFIC MANNER
683. GHRELIN RECEPTOR SIGNALLING IN THE EDINGER-WESTPHAL NUCLEUS REGULATES BINGE DRINKING IN A SEX-SPECIFIC MANNER Open
Background Binge drinking is the greatest predictor of the future development of alcohol use disorder. However, neurobiological sex differences in binge drinking remain poorly understood due to sex as a biological variable being historical…
View article: Inhibition of HCN channels decreases motivation for alcohol and deprivation-induced drinking in alcohol preferring rats
Inhibition of HCN channels decreases motivation for alcohol and deprivation-induced drinking in alcohol preferring rats Open
Globally, around 400 million people live with an alcohol use disorder (AUD), yet current treatments available are suboptimal at a population level. Hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels are implicated in…
View article: GHRELIN SIGNALLING MEDIATES SEX DIFFERENCES IN MIDBRAIN CONTROL OF BINGE DRINKING
GHRELIN SIGNALLING MEDIATES SEX DIFFERENCES IN MIDBRAIN CONTROL OF BINGE DRINKING Open
Background The circuitry mediating excessive alcohol consumption includes the understudied central projecting Edinger-Westphal (EWcp); a structure dense in neuropeptide expression, including cocaine and amphetamine regulated transcript (CA…
View article: Edinger-Westphal ghrelin receptor signalling regulates binge alcohol consumption in a sex specific manner
Edinger-Westphal ghrelin receptor signalling regulates binge alcohol consumption in a sex specific manner Open
Background Rates of risky drinking are continuing to rise, particularly in women, yet sex as a biological variable has been largely ignored. An emerging yet understudied potential component of this circuitry is the central projecting Eding…
View article: Ectopic HCN4 Provides a Target Biomarker for the Genetic Spectrum of mTORopathies
Ectopic HCN4 Provides a Target Biomarker for the Genetic Spectrum of mTORopathies Open
HCN4 provides a biomarker for the genetic spectrum of mTORopathies and may present a potential therapeutic target for seizure control in mTOR-related epilepsy.
View article: Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice
Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice Open
Changes in Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel function have been linked to depressive-like traits, making them potential drug targets. However, there is currently no peer-reviewed data supporting the use of a…
View article: Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy
Retinal Dysfunction in a Mouse Model of HCN1 Genetic Epilepsy Open
Pathogenic variants in HCN1 are associated with a range of epilepsy syndromes including a developmental and epileptic encephalopathy. The recurrent de novo HCN1 pathogenic variant (M305L) results in a cation leak, allowing the flux of exci…
View article: How the brain regulates alcohol intake
How the brain regulates alcohol intake Open
A neural pathway involved in goal-oriented behaviours becomes dysregulated during binge drinking and alcohol use disorder.
View article: Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy
Cation leak underlies neuronal excitability in an HCN1 developmental and epileptic encephalopathy Open
Pathogenic variants in HCN1 are associated with developmental and epileptic encephalopathies. The recurrent de novo HCN1 M305L pathogenic variant is associated with severe developmental impairment and drug-resistant epilepsy. We engineered…