Paulo C. Vieira
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View article: Co-culture exploration of some selected species of Fusarium, Pestalotiopsis and Colletotrichum in different culture media
Co-culture exploration of some selected species of Fusarium, Pestalotiopsis and Colletotrichum in different culture media Open
View article: Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors
Co‐cultivation and Medium Optimization: A Strategy for Discovering Fungal‐derived Protease Inhibitors Open
The fungi Fusarium guttiforme and Phytophthora palmivora were cultivated in four different media (Potato Dextrose Agar, Czapek, rice, and ISP2) and co‐cultured to stimulate fungal interactions and enhance secondary metabolite production. P…
View article: Exploring Bioactive Metabolites From <i>Fusarium falciforme</i> and <i>Aspergillus terreus</i> Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities
Exploring Bioactive Metabolites From <i>Fusarium falciforme</i> and <i>Aspergillus terreus</i> Isolated From Protease‐Rich Fruits: Antifungal, Antitrypanosomal, and Enzymatic Inhibitory Activities Open
Fungal secondary metabolites display remarkable chemical diversity and biological potential, with applications in agriculture and pharmaceuticals. This study isolated and characterized bioactive metabolites from two phytopathogenic fungi, …
View article: FK-1000: A Promising Antimicrobial Alternative for Shiga Toxin-Producing E. coli Infections
FK-1000: A Promising Antimicrobial Alternative for Shiga Toxin-Producing E. coli Infections Open
Antibiotic treatment is generally not recommended for Shiga toxin-producing Escherichia coli (STEC) infections due to the risk of enhancing toxin release, which worsens the patient’s clinical condition. Consequently, there is a pressing ne…
View article: Development of Xanthyletin-Loaded Nanoparticles for the Control of Leucoagaricus gongylophorus
Development of Xanthyletin-Loaded Nanoparticles for the Control of Leucoagaricus gongylophorus Open
This study describes the development, characterization and in vitro evaluation of poly(ε-caprolactone) (PCL) nanoparticles loaded with xanthyletin for the control of Atta sexdens rubropilosa through the inhibition of its symbiotic fungus L…
View article: New Colletotricandins and Thielavins Isolated from Colletotrichum gloeosporioides
New Colletotricandins and Thielavins Isolated from Colletotrichum gloeosporioides Open
This study investigates the chemical diversity and compares the metabolites of Colletotrichum gloeosporioides extracted from potato dextrose broth (PDB) and rice media. C. gloeosporioides is a fungal pathogen known for compromising proteas…
View article: Glioblastoma multiforme mimicking frontotemporal dementia: A case report
Glioblastoma multiforme mimicking frontotemporal dementia: A case report Open
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults. In this case a 57-year-old male patient had cognitive decline, visual dysfunction, and memory loss. He is not able to interact during the medical consultat…
View article: Phytochemical Investigation on Trichilia Elegans a. Juss (Meliaceae) and its Chemotaxonomic Significance
Phytochemical Investigation on Trichilia Elegans a. Juss (Meliaceae) and its Chemotaxonomic Significance Open
View article: Welcome to 2024
Welcome to 2024 Open
View article: ANÁLISE DE ÓLEOS VOLÁTEIS DE LÚPULO (Humulus lupulus L.) CASCADE E CHINOOK CULTIVADOS SOB CLIMA TROPICAL NO ESTADO DE SÃO PAULO
ANÁLISE DE ÓLEOS VOLÁTEIS DE LÚPULO (Humulus lupulus L.) CASCADE E CHINOOK CULTIVADOS SOB CLIMA TROPICAL NO ESTADO DE SÃO PAULO Open
ANALYSIS OF VOLATILE OILS FROM CASCADE AND CHINOOK HOPS (Humulus Lupulus L.) CULTIVATED UNDER TROPICAL CLIMATE IN THE STATE OF SÃO PAULO. Hop (Humulus lupulus L.) is a plant widely used as raw material in global beer production, valued for…
View article: Expectations for a New Scenario in Science and Technology
Expectations for a New Scenario in Science and Technology Open
View article: Integrated Analytical Tools Reveal New Myrsinoic Acids and Ache Ligands from Myrsine Guianensis (Aubl.) Kuntze
Integrated Analytical Tools Reveal New Myrsinoic Acids and Ache Ligands from Myrsine Guianensis (Aubl.) Kuntze Open
View article: Chemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18
Chemodiversity and Anti-Leukemia Effect of Metabolites from Penicillium setosum CMLD 18 Open
Penicillium setosum represents a Penicillium species recently described, with little up-to-date information about its metabolic and biological potential. Due to this scenario, we performed chemical and biological studies of P. setosum CMLD…
View article: Anacardic Acid Derivatives Affect the<i>in Vitro</i>Reactions of Photosynthesis
Anacardic Acid Derivatives Affect the<i>in Vitro</i>Reactions of Photosynthesis Open
The dichloromethane extract of the cashew nuts from Anacardium occidentale was fractionated by rotation locular countercurrent chromatography aimed at discovering metabolites that could be useful as new models for photosynthesis inhibitors…
View article: Combination of GC-MS Molecular Networking and Larvicidal Effect against Aedes aegypti for the Discovery of Bioactive Substances in Commercial Essential Oils
Combination of GC-MS Molecular Networking and Larvicidal Effect against Aedes aegypti for the Discovery of Bioactive Substances in Commercial Essential Oils Open
Dengue is a neglected disease, present mainly in tropical countries, with more than 5.2 million cases reported in 2019. Vector control remains the most effective protective measure against dengue and other arboviruses. Synthetic insecticid…
View article: In Silico Prediction and Design of Uropathogenic Escherichia coli Alpha-Hemolysin Generate a Soluble and Hemolytic Recombinant Toxin
In Silico Prediction and Design of Uropathogenic Escherichia coli Alpha-Hemolysin Generate a Soluble and Hemolytic Recombinant Toxin Open
The secretion of α-hemolysin by uropathogenic Escherichia coli (UPEC) is commonly associated with the severity of urinary tract infections, which makes it a predictor of poor prognosis among patients. Accordingly, this toxin has become a t…
View article: Forging Ahead, Despite Uncertainties
Forging Ahead, Despite Uncertainties Open
View article: Flavonoids and Insecticidal Activity Against Spodoptera frugiperda of Myrsine coriacea (Primulaceae)
Flavonoids and Insecticidal Activity Against Spodoptera frugiperda of Myrsine coriacea (Primulaceae) Open
This study was conducted to evaluate the insecticidal effects of Myrsine coriacea (Primulaceae) against one of the main pests of maize, the fall armyworm (Spodoptera frugiperda), as well as performing the phytochemical study of M. coriacea…
View article: New Synthetic Quinolines as Cathepsin K Inhibitors
New Synthetic Quinolines as Cathepsin K Inhibitors Open
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis. Quinolines a…
View article: RECENTES AVANÇOS NA FUNCIONALIZAÇÃO SELETIVA DE QUINOLINAS
RECENTES AVANÇOS NA FUNCIONALIZAÇÃO SELETIVA DE QUINOLINAS Open
RECENT ADVANCES IN SELECTIVE FUNCTIONALIZATION OF QUINOLINES. Heterocyclic compounds form an important and extensive group of organic substances. Among nitrogenous heterocyclic molecules, quinolines stand out for exhibiting attractive chem…
View article: What to Expect for the New Year?
What to Expect for the New Year? Open
View article: Inhibitory Activity and Docking Studies of Cathepsin V for Isoflavanoids from Dalbergia miscolobium Benth
Inhibitory Activity and Docking Studies of Cathepsin V for Isoflavanoids from Dalbergia miscolobium Benth Open
Resumo: Os extratos de plantas do gênero Dalbergia demonstram uma ampla gama de atividades biológicas, incluindo analgésica, antidiabética, anti-inflamatória e antimicrobiana.Neste trabalho, o estudo químico dos extratos das folhas e galho…
View article: Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses
Plant Natural Products for the Control of Aedes aegypti: The Main Vector of Important Arboviruses Open
The mosquito species Aedes aegypti is one of the main vectors of arboviruses, including dengue, Zika and chikungunya. Considering the deficiency or absence of vaccines to prevent these diseases, vector control remains an important strategy…
View article: Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites
Liquid Fungal Cocultivation as a Strategy to Access Bioactive Metabolites Open
Fungi are a rich source of bioactive compounds. Fungal cocultivation is a method of potentiating chemical interactions and, consequently, increasing bioactive molecule production. In this study, we evaluated the bactericidal, antiprotozoal…
View article: Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors
Green asymmetric synthesis of epoxypeptidomimetics and evaluation as human cathepsin K inhibitors Open
View article: Mycotoxins from Fusarium proliferatum: new inhibitors of papain-like cysteine proteases
Mycotoxins from Fusarium proliferatum: new inhibitors of papain-like cysteine proteases Open
View article: Secreted autotransporter toxin (Sat) induces cell damage during enteroaggregative Escherichia coli infection
Secreted autotransporter toxin (Sat) induces cell damage during enteroaggregative Escherichia coli infection Open
Secreted autotransporter toxin (Sat) is a 107-kDa serine protease autotransporter of Enterobacteriaceae (SPATE) presenting cytotoxic activity in renal and bladder cells. Further studies have detected the Sat-encoding gene (sat) in enteroag…
View article: Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata
Antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata Open
This study evaluated the antimicrobial activity of isolated compounds and semisynthetic derivatives from Miconia ferruginata (Melastomataceae) against five microorganisms: Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), …
View article: New Synthetic Quinolines as Cathepsin K Inhibitors
New Synthetic Quinolines as Cathepsin K Inhibitors Open
Cathepsin K is a papain-like cysteine protease and is responsible for collagen degradation in bone tissue and thus represents an important target for the development of new therapies for treating diseases such as osteoporosis.Quinolines ar…
View article: Isolated Compounds and Semi-Synthetic Derivatives from Miconia ferruginata as Inhibitors of Cathepsins K and B and their Cytotoxic Evaluation
Isolated Compounds and Semi-Synthetic Derivatives from Miconia ferruginata as Inhibitors of Cathepsins K and B and their Cytotoxic Evaluation Open
Resumo: O gênero Miconia, pertencente à família Melastomataceae, é amplamente distribuído na América tropical.Compostos isolados e derivados semissintéticos das folhas de Miconia ferruginata foram avaliados quanto à citotoxicidade em linha…