Pavana Anur
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View article: Benchmarking of germline copy number variant callers from whole genome sequencing data for clinical applications
Benchmarking of germline copy number variant callers from whole genome sequencing data for clinical applications Open
Motivation Whole-genome sequencing (WGS) is increasingly preferred for clinical applications due to its comprehensive coverage, effectiveness in detecting copy number variants (CNVs), and declining costs. However, systematic evaluations of…
View article: Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction
Crowd-sourced benchmarking of single-sample tumor subclonal reconstruction Open
View article: Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project
Novel recruitment approaches and operational results for a statewide population Cohort for cancer research: The Healthy Oregon Project Open
Background: Cancer health research relies on large-scale cohorts to derive generalizable results for different populations. While traditional epidemiological cohorts often use costly random sampling or self-motivated, preselected groups, a…
View article: Population screening shows risk of inherited cancer and familial hypercholesterolemia in Oregon
Population screening shows risk of inherited cancer and familial hypercholesterolemia in Oregon Open
View article: Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S6 contains results from the analysis of DNA methylation in SETD2 mutated and BAP1 inactivated samples.
View article: Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S7 contains microbe screening results.
View article: Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Supplementary materials and methods, as well as supplementary figures S1-S7.
View article: Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S1 contains cohort description, Master Patient Table and MutSigCV results.
View article: Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S4 includes immune signature and iCluster results.
View article: Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S2 contains BAP1 analysis results, as well as detailed lists of YY1 and IRF8 target genes.
View article: Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S5 contains detailed miRs and lncRNAs results.
View article: Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S3 contains the karyotypes of 16 genome-wide LOH MPM cases from the BWH cohort.
View article: Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S3 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S3 contains the karyotypes of 16 genome-wide LOH MPM cases from the BWH cohort.
View article: Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S4 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S4 includes immune signature and iCluster results.
View article: Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1
View article: Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Supplementary Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Supplementary materials and methods, as well as supplementary figures S1-S7.
View article: Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S5 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S5 contains detailed miRs and lncRNAs results.
View article: Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S7 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S7 contains microbe screening results.
View article: Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Data from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest cavity. To expand our understanding of MPM, we conducted a comprehensive integrated genomic study, including the most detailed analysis of BAP1
View article: Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S2 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S2 contains BAP1 analysis results, as well as detailed lists of YY1 and IRF8 target genes.
View article: Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S6 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S6 contains results from the analysis of DNA methylation in SETD2 mutated and BAP1 inactivated samples.
View article: Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma
Table S1 from Integrative Molecular Characterization of Malignant Pleural Mesothelioma Open
Table S1 contains cohort description, Master Patient Table and MutSigCV results.
View article: Supplementary Figure 4 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 4 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 76K, The c-Src inhibitor blocked apoptosis-related genes induced by E2. MCF-7:5C cells were treated with vehicle (0.1% DMSO), E2 (10-9 mol/L), 4-OHT (10-6 mol/L), E2 (10-9 mol/L) plus 4-OHT(10-6 mol/L), PP2 (5x10-6 mol/L), E2 (1…
View article: Data from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Data from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
The emergence of anti-estrogen resistance in breast cancer is an important clinical phenomenon affecting long-term survival in this disease. Identifying factors that convey cell survival in this setting may guide improvements in treatment.…
View article: Supplementary Figure 5 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 5 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 47K, 5A, The oxidative stress indicator HMOX1 expressed in wild-type MCF-7 cells after E2 treatment. Wild-type MCF-7 cells were cultured in E2 free medium for three days. Then, cells were plated in six-well plates. After one day…
View article: Supplementary Figure 2 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 2 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 104K, 2A, Activation of pS2 by different concentrations of estrogen dendrimer conjugate (EDC). MCF-7:5C cells were treated with vehicle (0.1% MeOH), different concentrations of EDC, E2, and empty dendrimer as indicated for 8 hou…
View article: Supplementary Figure 6 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 6 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 82K, 6A, The c-Src inhibitor blocked tumor necrosis factor (TNF) super family genes induced by E2. MCF-7:5C cells were treated with vehicle (0.1% DMSO), E2 (10-9 mol/L), 4-OHT (10-6 mol/L), E2 (10-9 mol/L) plus 4-OHT (10-6 mol/L…
View article: Supplementary Figure 5 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 5 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 47K, 5A, The oxidative stress indicator HMOX1 expressed in wild-type MCF-7 cells after E2 treatment. Wild-type MCF-7 cells were cultured in E2 free medium for three days. Then, cells were plated in six-well plates. After one day…
View article: Supplementary Figure 1 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 1 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 77K, 1A, The c-Src inhibitor blocked E2 activated non-genomic pathway. MCF-7:5C cells were treated with vehicle (0.1% DMSO), E2 (10-9 mol/L), PP2 (5x10-6 mol/L), E2 (10-9 mol/L) plus PP2 (5x10-6 mol/L) respectively for 10 minute…
View article: Supplementary Figure 4 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells
Supplementary Figure 4 from c-Src Modulates Estrogen-Induced Stress and Apoptosis in Estrogen-Deprived Breast Cancer Cells Open
PDF file - 76K, The c-Src inhibitor blocked apoptosis-related genes induced by E2. MCF-7:5C cells were treated with vehicle (0.1% DMSO), E2 (10-9 mol/L), 4-OHT (10-6 mol/L), E2 (10-9 mol/L) plus 4-OHT(10-6 mol/L), PP2 (5x10-6 mol/L), E2 (1…