Pavel Chrobák
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View article: HIV Nef disrupts Lck signaling by inducing aberrant phosphorylation of its substrates
HIV Nef disrupts Lck signaling by inducing aberrant phosphorylation of its substrates Open
Human in vitro studies of HIV Nef on TcR proximal signaling have been controversial and have not provided an integrated picture of its impact. Tyrosine (Y) phosphorylation (pY) of Lck and its substrates (CD3ζ, Zap-70) was investigated in v…
View article: Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma
Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma Open
Inhibition of adenosine A2A receptor (A2AR) is a promising approach for cancer immunotherapy currently evaluated in several clinical trials. We here report that anti-obesogenic and anti-inflammatory functions of A2AR, however, significantl…
View article: Table of Contents
Table of Contents Open
View article: Data from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer
Data from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer Open
The ectonucleotidases CD39 and CD73 catalyze extracellular ATP to immunosuppressive adenosine, and as such, represent potential cancer targets. We investigated biological impacts of CD39 and CD73 in pancreatic ductal adenocarcinoma (PDAC) …
View article: Data from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer
Data from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer Open
The ectonucleotidases CD39 and CD73 catalyze extracellular ATP to immunosuppressive adenosine, and as such, represent potential cancer targets. We investigated biological impacts of CD39 and CD73 in pancreatic ductal adenocarcinoma (PDAC) …
View article: Supplementary Tables and Figures from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer
Supplementary Tables and Figures from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer Open
supplementary Table S1 to S3; Supplementary Figure S1 to S9
View article: Supplementary Tables and Figures from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer
Supplementary Tables and Figures from CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer Open
supplementary Table S1 to S3; Supplementary Figure S1 to S9
View article: Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors Open
Innate and adaptive immune cells play an important role in the therapeutic activity of anti-ErbB2 mAbs, such as trastuzumab. In the clinic, breast tumors poorly infiltrated with immune cells are more resistant to trastuzumab, and patients …
View article: Supplementary Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Supplementary Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors Open
Data of memory response, single agent activity, tumor sizes at time of flow cytometry analysis and antibody-mediated cellular cytotoxicity of trastuzumab-treated BT-474 cells is shown.
View article: Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors Open
Innate and adaptive immune cells play an important role in the therapeutic activity of anti-ErbB2 mAbs, such as trastuzumab. In the clinic, breast tumors poorly infiltrated with immune cells are more resistant to trastuzumab, and patients …
View article: Supplementary Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
Supplementary Data from PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors Open
Data of memory response, single agent activity, tumor sizes at time of flow cytometry analysis and antibody-mediated cellular cytotoxicity of trastuzumab-treated BT-474 cells is shown.
View article: NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases
NEF-Induced HIV-Associated Nephropathy Through HCK/LYN Tyrosine Kinases Open
View article: CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer
CD73 Inhibits cGAS–STING and Cooperates with CD39 to Promote Pancreatic Cancer Open
The ectonucleotidases CD39 and CD73 catalyze extracellular ATP to immunosuppressive adenosine, and as such, represent potential cancer targets. We investigated biological impacts of CD39 and CD73 in pancreatic ductal adenocarcinoma (PDAC) …
View article: CD73 Promotes Chronic Lymphocytic Leukemia
CD73 Promotes Chronic Lymphocytic Leukemia Open
The ecto-nucleotidase CD73 is an important immune checkpoint in tumor immunity that cooperates with CD39 to hydrolyze pro-inflammatory extracellular ATP into immunosuppressive adenosine. While the role of CD73 in immune evasion of solid ca…
View article: High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer
High-dimensional analysis of the adenosine pathway in high-grade serous ovarian cancer Open
Background Hydrolysis of extracellular ATP to adenosine (eADO) is an important immune checkpoint in cancer immunology. We here investigated the impact of the eADO pathway in high-grade serous ovarian cancer (HGSC) using multiparametric pla…
View article: NR4A Expression by Human Marginal Zone B-Cells
NR4A Expression by Human Marginal Zone B-Cells Open
We have previously characterized a human blood CD19+CD1c+IgM+CD27+CD21loCD10+ innate-like B-cell population, which presents features shared by both transitional immature and marginal zone (MZ) B-cells, named herein “precursor-like” MZ B-ce…
View article: Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis
Adenosine A2a receptor promotes lymphangiogenesis and lymph node metastasis Open
The formation of new lymphatic vessels, or lymphangiogenesis, is a critical step of the tissue repair program. In pathological conditions involving chronic inflammation or tumorigenesis, this process is often dysregulated and can contribut…
View article: WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors
WISP1 is associated to advanced disease, EMT and an inflamed tumor microenvironment in multiple solid tumors Open
Background: WNT1-Inducible Signaling Pathway Protein 1 (WISP1) is implicated in prostate cancer growth and metastasis and the regulation of inflammation in diverse benign diseases. The objectives of this study were to assess the pro…
View article: CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination
CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination Open
Many individuals at risk of streptococcal infection respond poorly to the pneumococcal polysaccharide vaccine Pneumovax 23. Identification of actionable pathways able to enhance Pneumovax responsiveness is highly relevant. We investigated …
View article: PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors
PolyI:C and CpG Synergize with Anti-ErbB2 mAb for Treatment of Breast Tumors Resistant to Immune Checkpoint Inhibitors Open
Innate and adaptive immune cells play an important role in the therapeutic activity of anti-ErbB2 mAbs, such as trastuzumab. In the clinic, breast tumors poorly infiltrated with immune cells are more resistant to trastuzumab, and patients …
View article: CD73 in Autoimmune Arthritis
CD73 in Autoimmune Arthritis Open
Adenosine is a potent anti-inflammatory molecule that plays an important role in many diseases. Extracellular levels of adenosine are determined by a combination of membrane transporters and ecto-nucleotidases such as CD73. Therapeutic tar…
View article: The A2A adenosine receptor regulates the formation of new lymphatic vessels in inflammatory micro environments
The A2A adenosine receptor regulates the formation of new lymphatic vessels in inflammatory micro environments Open