Pavel Drašar
YOU?
Author Swipe
View article: Early Sugar Industry in Bohemia, Teaching of Sugar and Carbohydrate Chemistry at the Prague Polytechnic and Later at the University of Chemistry and Technology Prague
Early Sugar Industry in Bohemia, Teaching of Sugar and Carbohydrate Chemistry at the Prague Polytechnic and Later at the University of Chemistry and Technology Prague Open
The article describes the early history of sugar industry and sugar chemistry in the Czech Republic and the development of sugar chemistry teaching at the Prague Polytechnic, Czech Technical University and at the University of Chemistry an…
View article: The Imperial Flower of the Autumn Sun, Full of Healing Power
The Imperial Flower of the Autumn Sun, Full of Healing Power Open
Chrysanthemum is described as a food, among other things, to obtain a delicious infusion, but also as a very interesting and effective medicinal herb, both from the point of view of traditional oriental medicine and contemporary "Western" …
View article: The Healing Power of the Gifts of the Magi
The Healing Power of the Gifts of the Magi Open
The article describes two of the three gifts that the mysterious Magi brought to the baby Jesus in Bethlehem to celebrate his birth, frankincense and myrrh. Full text English translation is available in the on-line version.
View article: Triazole-Based Radioligands for PET of P2X<sub>7</sub>R: Syntheses, Conformational Studies, and Preliminary Autoradiographic Evaluation of <b>[<sup>18</sup>F]AM-10</b>
Triazole-Based Radioligands for PET of P2X<sub>7</sub>R: Syntheses, Conformational Studies, and Preliminary Autoradiographic Evaluation of <b>[<sup>18</sup>F]AM-10</b> Open
The P2X7 receptor is an emerging target for molecular imaging of inflammation in the brain and peripheral tissues. In this work, we focus on five triazole-based ligands with high affinity and selectivity for P2X7 rece…
View article: Roots of the Association of Chemists (Natural Scientists) in Today's Slovakia and Officials of the Czechoslovak Chemical Society from Slovakia
Roots of the Association of Chemists (Natural Scientists) in Today's Slovakia and Officials of the Czechoslovak Chemical Society from Slovakia Open
The article describes the roots and development of organizations of the Slovak natural scientists and chemists and their involvement in the later Czechoslovak Chemical Society. The aim of the article was to map the history of professional …
View article: On the Development of the Organization of Slovak Chemists during the Inter-War Czechoslovak Republic
On the Development of the Organization of Slovak Chemists during the Inter-War Czechoslovak Republic Open
The article provides more detailed information about the first decade of the development of the organization of Slovak chemists.
View article: Lost Foundation Stone
Lost Foundation Stone Open
View article: Colchicine-BODIPY Probes: Evidence for the Involvement of Intracellular Membranes in the Targeting of Colchicine to Tubulin
Colchicine-BODIPY Probes: Evidence for the Involvement of Intracellular Membranes in the Targeting of Colchicine to Tubulin Open
The natural product colchicine (Col) is a medication used to treat severe inflammatory conditions. Although its mechanism of action at the level of the cytoskeleton is known, its subcellular distribution has not yet been properly st…
View article: On the 45ᵗʰ Anniversary of the Decease of František Šorm and His Short Tenure at the Faculty of Chemistry, Czech Technical University
On the 45ᵗʰ Anniversary of the Decease of František Šorm and His Short Tenure at the Faculty of Chemistry, Czech Technical University Open
The article presents a personal recollection of František Šorm and a basic information about his work at the present-day University of Chemistry and Technology in Prague, as well as at the Faculty of Science of the Charles University in Pr…
View article: Department of Chemistry of Natural Compounds of UCT Prague; Roots and Origin
Department of Chemistry of Natural Compounds of UCT Prague; Roots and Origin Open
The article provides searchable information about the establishment of the Laboratory of Heterocyclic Chemistry and its transformation into the Laboratory of Monosaccharides and the Department of Chemistry of Natural Compounds of the Insti…
View article: Early Terpene Chemistry in the Czech Lands
Early Terpene Chemistry in the Czech Lands Open
The article provides essential information about the beginnings of terpene research in Czechoslovakia and about the key figures who participated in it.
View article: Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review
Alkaloids from the genus Vinca L. (Apocynaceae): a comprehensive biological and structural review Open
This review provides a comprehensive overview of the alkaloids in the genus Vinca L. (Apocynaceae), which is renowned for its rich content of monoterpene indole alkaloids and widespread occurrence in Europe, northwest Africa, and southwest…
View article: Ashwagandha, the Ayurvedic Fountain of Youth
Ashwagandha, the Ayurvedic Fountain of Youth Open
The paper characterizes the medicinal plant Withania somnifera and provides data on the basic compounds contained and biological efficacy. Full text English translation is available in the on-line version.
View article: Journals of the Czech Chemical Engineering Community
Journals of the Czech Chemical Engineering Community Open
The article provides an overview of Czech chemical journals focused on chemical technology, engineering and practice.
View article: A Lesson from Crisis
A Lesson from Crisis Open
View article: Sarva Roga Nivarini, Gift of the Gods
Sarva Roga Nivarini, Gift of the Gods Open
The article deals with the Azadirachta indica tree, called neem, which, as well as its products, is used in traditional medicine, agrochemicals, as a source of biologically active substances, but also as part of food. It describes the main…
View article: Isolation of Trilobolide from Stems and Leaves of the Horse Caraway
Isolation of Trilobolide from Stems and Leaves of the Horse Caraway Open
Isolation of trilobolide from the stems and leaves of horse caraway is simple and, despite the lower content of the substance, appears to be economical due to the quantity of material that can be available and thanks to a relatively simple…
View article: The Beginnings of Steroid Chemistry in The Czech Lands
The Beginnings of Steroid Chemistry in The Czech Lands Open
Steroid research in the Czech Republic has a long tradition, and this article takes the liberty of summarizing the most important details and information that the author remembers and that he managed to find.
View article: Representatives of the Chemical Community in Bohemia, Czechoslovakia and Slovakia
Representatives of the Chemical Community in Bohemia, Czechoslovakia and Slovakia Open
The article provides a summary of a series of publications mapping representatives of chemical companies, editors-in-chief of chemical journals and officials of Czech Chemical Society (ČSCH) and Slovak Chemical Society (SCHS).
View article: Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation
Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation Open
Estradiol dimers (EDs) possess significant anticancer activity by targeting tubulin dynamics. In this study, we synthesised 12 EDs variants via copper-catalysed azide-alkyne cycloaddition (CuAAC) reaction, focusing on structural modificati…
View article: Studying the Specific (Adaptogenic and Anabolic) Activity of the Supramolecular Complex of 20-Hydroxyecdysone Triacetate with β-Cyclodextrin
Studying the Specific (Adaptogenic and Anabolic) Activity of the Supramolecular Complex of 20-Hydroxyecdysone Triacetate with β-Cyclodextrin Open
BACKGROUND: A supramolecular complex of ecdysterone triacetate with β-cyclodextrin (β-CD) was synthesized to obtain new potentially bioactive substances and study the effect of bulky pharmacophore-functional groups on the preservation of t…
View article: Strong Willow Bark Brew
Strong Willow Bark Brew Open
The story of aspirin is exciting and complicated. We tried to decipher the role of the main characters, as well as a wide field of pharmacological roles of acetylsalicylic acid, a super-drug, which would not be approved by responsible inst…
View article: A facile synthesis of precursor for the σ‐1 receptor PET radioligand [<sup>18</sup>F]FTC‐146 and its radiofluorination
A facile synthesis of precursor for the σ‐1 receptor PET radioligand [<sup>18</sup>F]FTC‐146 and its radiofluorination Open
The σ‐1 receptor is a non‐opioid transmembrane protein involved in various human pathologies including neurodegenerative diseases, inflammation, and cancer. The previously published ligand [ 18 F]FTC‐146 is among the most promising tools f…
View article: On the Separation and Strengthening of the Image Behind the Mirror (Deracemization and Chirality Amplification)
On the Separation and Strengthening of the Image Behind the Mirror (Deracemization and Chirality Amplification) Open
The article describes the basic aspects of chirality, reflects on the origin of the chirality of chemical compounds and brings a view of the basic processes during deracemization. The article indicates the boundlessness of the topic of chi…
View article: Chairmen of Slovak Chemists' Associations until the End of the 20ᵗʰ Century
Chairmen of Slovak Chemists' Associations until the End of the 20ᵗʰ Century Open
The article lists the presidents of Slovak chemists' associations from 1929 to the end of the 20th century.
View article: Humic Substances: Characterisation and Nomenclatural Recommendations
Humic Substances: Characterisation and Nomenclatural Recommendations Open
View article: On the Strength of Punjabi Asphalt
On the Strength of Punjabi Asphalt Open
Mumio (shilajit), a substance similar to asphalt or resin that oozes from rocks during hot sunny days, mostly in caves in the Himalayas, is known as a medicinal substance in Eastern medicine. It is slowly being accepted by Western healing …
View article: Improved syntheses of P2X7 ligands based on substituted benzyl amide of pyroglutamic acid motif labelled with iodine-123 or iodine-125
Improved syntheses of P2X7 ligands based on substituted benzyl amide of pyroglutamic acid motif labelled with iodine-123 or iodine-125 Open
P2X 7 sites are emerging targets for molecular imaging research, notably in the context of neurodegeneration and inflammatory conditions. Therefore, we prepared a precursor for (radio)iodination of the P2X 7 ligand VPGIS191. We then develo…
View article: On Forest Entheogen
On Forest Entheogen Open
The article describes the red toadstool, Amanita muscaria, in the mirror of history, natural medicine, content of substances, and toxicity, as well as within the context of shamanic, ritual, and religious practices. Based on scientific rea…
View article: The Only Chairman of the Society for the Chemical Industry in the Kingdom of Bohemia 1893–1907
The Only Chairman of the Society for the Chemical Industry in the Kingdom of Bohemia 1893–1907 Open
The article describes basic data on the only chairman of the Society for the Chemical Industry in the Kingdom of Bohemia 1893–1907, Jan Baptista Lambl.