Pavel Hamet
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View article: Prediction of Cardiovascular and Renal Complications of Diabetes by a multi-Polygenic Risk Score in Different Ethnic Groups
Prediction of Cardiovascular and Renal Complications of Diabetes by a multi-Polygenic Risk Score in Different Ethnic Groups Open
We developed a multi-Polygenic risk score (multiPRS) to predict the risk of nephropathy, stroke, and myocardial infarction in people with type 2 diabetes of European descent. The underrepresentation of non-European populations remains a ma…
View article: Contrasting Role of COMMD5 in Renal Cell Carcinoma: Tumor Suppression and Metastatic Enhancement
Contrasting Role of COMMD5 in Renal Cell Carcinoma: Tumor Suppression and Metastatic Enhancement Open
COMMD5 plays dual roles in RCC progression, as a tumor suppressor and a metastasis enhancer.
View article: Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE
Healthy lifestyle factors and combined macrovascular and microvascular events in diabetes patients with high cardiovascular risk: results from ADVANCE Open
View article: <b>Intensive glucose lowering and its effects on vascular events and death according to age at diagnosis and duration of diabetes: the ADVANCE trial</b>
<b>Intensive glucose lowering and its effects on vascular events and death according to age at diagnosis and duration of diabetes: the ADVANCE trial</b> Open
Objective: To compare the vascular effects of pursuing more versus less glucose lowering in patients with younger or older age at diabetes diagnosis, and with shorter or longer diabetes duration.Research Design and Methods: We studied 11,1…
View article: <b>Intensive glucose lowering and its effects on vascular events and death according to age at diagnosis and duration of diabetes: the ADVANCE trial</b>
<b>Intensive glucose lowering and its effects on vascular events and death according to age at diagnosis and duration of diabetes: the ADVANCE trial</b> Open
Objective: To compare the vascular effects of pursuing more versus less glucose lowering in patients with younger or older age at diabetes diagnosis, and with shorter or longer diabetes duration.Research Design and Methods: We studied 11,1…
View article: Effect of randomised blood pressure lowering treatment and intensive glucose control on dementia and cognitive decline according to baseline cognitive function and other subpopulations of individuals with type 2 diabetes: Results from the ADVANCE trial
Effect of randomised blood pressure lowering treatment and intensive glucose control on dementia and cognitive decline according to baseline cognitive function and other subpopulations of individuals with type 2 diabetes: Results from the ADVANCE trial Open
ADVANCE is registered with ClinicalTrials.gov: number NCT00145925.
View article: X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements Open
View article: Leveraging hierarchical structures for genetic block interaction studies using the hierarchical transformer
Leveraging hierarchical structures for genetic block interaction studies using the hierarchical transformer Open
Initially introduced in 1909 by William Bateson, classic epistasis (genetic variant interaction) refers to the phenomenon that one variant prevents another variant from a different locus from manifesting its effects. The potential effects …
View article: Combination blood pressure lowering therapy in patients with type 2 diabetes: messages from the ADVANCE trial
Combination blood pressure lowering therapy in patients with type 2 diabetes: messages from the ADVANCE trial Open
The Action in Diabetes and Vascular disease: preterAx and diamicroN Controlled Evaluation (ADVANCE) trial investigated the effects of intensive blood pressure (BP) lowering using a fixed combination of perindopril-indapamide versus placebo…
View article: X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements
X-chromosome and kidney function: evidence from a multi-trait genetic analysis of 908,697 individuals reveals sex-specific and sex-differential findings in genes regulated by androgen response elements Open
X-chromosomal genetic variants are understudied but can yield valuable insights into sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry X-chromosome-wide association meta-analysis of seven kidney-rel…
View article: Cumulative Systolic Blood Pressure Load and Cardiovascular Risk in Patients With Diabetes
Cumulative Systolic Blood Pressure Load and Cardiovascular Risk in Patients With Diabetes Open
View article: Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality
Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality Open
Background and objectives Hyperkalemia after starting renin-angiotensin system inhibitors has been shown to be subsequently associated with a higher risk of cardiovascular and kidney outcomes. However, whether to continue or discontinue th…
View article: Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies Open
View article: Correction to: Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control
Correction to: Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control Open
View article: Cover Image, Volume 23, Issue 8
Cover Image, Volume 23, Issue 8 Open
The cover image is based on the Original Article Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the ADVANCE trial by Jessica Gong et al., …
View article: Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control
Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control Open
View article: COMMD5 Inhibits Malignant Behavior of Renal Cancer Cells
COMMD5 Inhibits Malignant Behavior of Renal Cancer Cells Open
COMMD5 might suppress malignant phenotypes of RCC, thus inhibiting tumor development and improving patient prognosis.
View article: The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial
The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial Open
Objective. To develop a frailty index (FI) and explore the relationship of frailty to subsequent adverse outcomes on the effectiveness and safety of more intensive control of both blood glucose and blood pressure (BP), amongst parti…
View article: The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure–Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial
The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure–Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial Open
OBJECTIVE To develop a frailty index (FI) and explore the relationship of frailty to subsequent adverse outcomes on the effectiveness and safety of more intensive control of both blood glucose and blood pressure (BP), among participants wi…
View article: The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial
The Impact of Frailty on the Effectiveness and Safety of Intensive Glucose Control and Blood Pressure-Lowering Therapy for People With Type 2 Diabetes: Results From the ADVANCE Trial Open
Objective. To develop a frailty index (FI) and explore the relationship of frailty to subsequent adverse outcomes on the effectiveness and safety of more intensive control of both blood glucose and blood pressure (BP), amongst parti…
View article: Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the <scp>ADVANCE</scp> trial
Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the <span>ADVANCE</span> trial Open
Aim To estimate the associations between risk factors and cognitive decline (CD)/dementia, and the sex differences in these risk factors in individuals with type 2 diabetes, while accounting for the competing risk of death. Materials and M…
View article: Author response for "Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the ADVANCE trial"
Author response for "Sex differences in risk factors for cognitive decline and dementia, including death as a competing risk, in individuals with diabetes: Results from the ADVANCE trial" Open
View article: Variability in estimated glomerular filtration rate and the risk of major clinical outcomes in diabetes: Post hoc analysis from the <scp>ADVANCE</scp> trial
Variability in estimated glomerular filtration rate and the risk of major clinical outcomes in diabetes: Post hoc analysis from the <span>ADVANCE</span> trial Open
There are limited data on whether estimated glomerular filtration rate (eGFR) variability modifies the risk of future clinical outcomes in type 2 diabetes (T2D). We assessed the association between 20‐month eGFR variability and the risk of…
View article: Author response for "Variability in eGFR and the risk of major clinical outcomes in diabetes: post‐hoc analysis from the ADVANCE trial"
Author response for "Variability in eGFR and the risk of major clinical outcomes in diabetes: post‐hoc analysis from the ADVANCE trial" Open
View article: SARS–CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking
SARS–CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking Open
BACKGROUND Angiotensin-converting enzyme 2 (ACE2) has been identified as the entry receptor for coronaviruses into human cells, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (CO…
View article: Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline Open
View article: Alternative kidney filtration markers and the risk of major macrovascular and microvascular events, and <scp>all‐cause</scp> mortality in individuals with type 2 diabetes in the <scp>ADVANCE</scp> trial
Alternative kidney filtration markers and the risk of major macrovascular and microvascular events, and <span>all‐cause</span> mortality in individuals with type 2 diabetes in the <span>ADVANCE</span> trial Open
Background Creatinine‐based estimated glomerular filtration rate (eGFR) is biased in the setting of obesity and other conditions. Alternative kidney filtration markers may be useful in adults with diabetes, but few studies examined the ass…
View article: Sex‐specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: The <scp>ADVANCE‐ON</scp> study
Sex‐specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: The <span>ADVANCE‐ON</span> study Open
Aim To examine possible sex differences in the excess risk of myocardial infarction (MI) consequent to a range of conventional risk factors in a large‐scale international cohort of patients with diabetes, and to quantify these potential di…
View article: Author response for "Sex‐specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: the <scp>ADVANCE‐ON</scp> study"
Author response for "Sex‐specific associations between cardiovascular risk factors and myocardial infarction in patients with type 2 diabetes: the <span>ADVANCE‐ON</span> study" Open
View article: Plasma fatty acids and the risk of vascular disease and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE study
Plasma fatty acids and the risk of vascular disease and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE study Open
Aims/hypothesis This biomarker study aimed to quantify the association of essential and other plasma fatty acid biomarkers with macrovascular disease, microvascular disease and death in individuals with type 2 diabetes. Methods A case-coho…