Pavithra Premkumar
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View article: Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione
Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione Open
Neurotoxic regimens of methamphetamine (METH) are known to increase reactive oxygen species (ROS), affect redox homeostasis, and lead to damage in dopamine neurons. Functional changes induced by long-term METH self-administration on mitoch…
View article: Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration and Dopamine Neuron Firing Activity
Methamphetamine Self-Administration Differential Effects on Mesolimbic Glutathione Levels, Mitochondrial Respiration and Dopamine Neuron Firing Activity Open
Acute and neurotoxic regimens of METH are known to increase reactive oxygen species (ROS), affect redox homeostasis, and lead to cellular damage in dopamine neurons. However, functional changes induced by long-term METH self-administration…
View article: Linear growth in children with type I diabetes mellitus – A one-year prospective study
Linear growth in children with type I diabetes mellitus – A one-year prospective study Open
Introduction: Reduced growth velocity and delayed pubertal spurt are seen in Type1 diabetes mellitus and are influenced by a variety of factors. Objective: The objective of the study was to study various factors affecting linear growth in …
View article: Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function Open
Age-related decline in circulating levels of insulin-like growth factor (IGF)-1 is associated with reduced cognitive function, neuronal aging, and neurodegeneration. Decreased mitochondrial function along with increased reactive oxygen spe…
View article: Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching Open
Background Excess reactive oxygen species (ROS) and muscle weakness occur in parallel in multiple pathological conditions. However, the causative role of skeletal muscle mitochondrial ROS (mtROS) on neuromuscular junction (NMJ) morphology …
View article: Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness
Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness Open
Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice ( Sod1 −/− mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mir…
View article: Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes
Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes Open
Regulation of astrocytic mitochondrial function and redox status by IGF-1 is essential to maintain astrocytic function and coordinate hippocampal-dependent spatial learning. Age-related astrocytic dysfunction caused by diminished IGF-1 sig…