K Pavithran
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View article: Integration of Ayurveda in managing chemotherapy-induced hand–foot–skin reaction—an exploratory quasi experimental study
Integration of Ayurveda in managing chemotherapy-induced hand–foot–skin reaction—an exploratory quasi experimental study Open
Introduction Hand–foot–skin reaction (HFSR) is one of the major mucocutaneous adverse events of multi-kinase inhibitors (MKIs). Its overall incidence is 35.0%. It negatively impacts the quality of life of the patient and compliance with ch…
View article: Practice Patterns and Outcomes in Advanced Colorectal Cancers From a Multi-Institutional Analysis: Real-World Evidence From India
Practice Patterns and Outcomes in Advanced Colorectal Cancers From a Multi-Institutional Analysis: Real-World Evidence From India Open
PURPOSE There are limited data on presentation and practice patterns, survival, and factors influencing overall survival (OS) in Indian patients with metastatic colorectal cancers (mCRCs). PATIENTS AND METHODS The current study evaluated p…
View article: Risk of gynaecologic cancers in women with metabolic syndrome: A systematic review & meta-analysis
Risk of gynaecologic cancers in women with metabolic syndrome: A systematic review & meta-analysis Open
Background & objectives Metabolic syndrome may be associated with the risk of gynaecological cancers. This systematic review aims to evaluate the risk of gynaecological cancers among women with metabolic syndrome. Methods Studies published…
View article: Projection of age-standardised mortality rates for 23 cancer types in India: a nationwide projection until 2030 using autoregressive integrated moving average (ARIMA) models
Projection of age-standardised mortality rates for 23 cancer types in India: a nationwide projection until 2030 using autoregressive integrated moving average (ARIMA) models Open
Objectives To project the future burden of cancer mortality in India by forecasting age-standardised mortality rates (ASMRs) for 23 major cancer types up to the year 2030, providing crucial evidence for long-term health planning and resour…
View article: The Malayalam version of fear of cancer recurrence-7 scale: A cross-sectional study on translation and validation among breast cancer survivors
The Malayalam version of fear of cancer recurrence-7 scale: A cross-sectional study on translation and validation among breast cancer survivors Open
Background: Fear of cancer recurrence (FCR) affects up to 89% of survivors, impairing quality of life (QoL). The fear of cancer recurrence-7 (FCR-7) is a reliable tool, but no validated Malayalam version exists. Objectives: The primary obj…
View article: Pure Large Cell Neuroendocrine Carcinoma Originating from the Endometrium: A Case Report and Review of Literature
Pure Large Cell Neuroendocrine Carcinoma Originating from the Endometrium: A Case Report and Review of Literature Open
A BSTRACT Large cell neuroendocrine carcinoma (LCNEC) of the endometrium is a rare and aggressive high-grade malignancy, constituting fewer than 1% of endometrial malignancies, with only 33 cases reported in the literature to date. We pres…
View article: Vorasidenib: A narrative drug review
Vorasidenib: A narrative drug review Open
Isocitrate dehydrogenase (IDH) mutations (IDH1 and IDH2) are observed in malignancies such as low-grade gliomas, acute myeloid leukemia, cholangiocarcinoma, and chondrosarcoma. Vorasidenib is a targeted therapy for IDH-mutant gliomas that …
View article: Multimodal management and outcome of pediatric and adolescent malignant central nervous system tumors: A single‐center retrospective study
Multimodal management and outcome of pediatric and adolescent malignant central nervous system tumors: A single‐center retrospective study Open
Objective There is a paucity of real‐world evidence in the Indian context to address the outcome of primary brain tumors (PBTs) in children. This study aimed to describe the demographic profile, clinical characteristics, and histological f…
View article: Adverse Reactions to Taxanes in Premedicated Cancer Patients: A Prospective Observational Study
Adverse Reactions to Taxanes in Premedicated Cancer Patients: A Prospective Observational Study Open
IRRs accounted for only a small number of adverse events (3.8%) due to taxanes in premedicated cancer patients, and neither these reactions nor non-IRRs led to the discontinuation of therapy. Integrating desensitization protocols and the P…
View article: A STUDY TO ASSESS THE EFFECTIVENESS OF PEPPERMINT ON ORAL MUCOSITIS AMONG PATIENTS RECEIVING CHEMOTHERAPY AND RADIATION THERAPY.
A STUDY TO ASSESS THE EFFECTIVENESS OF PEPPERMINT ON ORAL MUCOSITIS AMONG PATIENTS RECEIVING CHEMOTHERAPY AND RADIATION THERAPY. Open
Quasi Experimental research design where pre and post test with control group design was used to evaluate the effectiveness of peppermint on oral mucositis among patients receiving chemotherapy and radiation therapy. With help of convenien…
View article: Epidemiological and histopathological profile of lung Cancer: Insights from a 15-year cross-sectional study at a tertiary care centre in South India
Epidemiological and histopathological profile of lung Cancer: Insights from a 15-year cross-sectional study at a tertiary care centre in South India Open
Background In India, lung cancer accounts for 5.9 % of all cancers and 8.1 % of all cancer-related deaths, with adenocarcinoma emerging as the most common histopathological subtype in developing countries. Aims To analyze the shifting tren…
View article: Reducing chemotherapy waiting times at a comprehensive cancer centre through telephonic triaging
Reducing chemotherapy waiting times at a comprehensive cancer centre through telephonic triaging Open
Background: In day-care chemotherapy facilities, long chemotherapy infusion wait times negatively impact patient experience. To resolve this problem, we implemented a quality improvement initiative using the - determining the problem, meas…
View article: Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center
Clinical and Pathological Spectrum of Hepatoblastoma with Emphasis on Treatment-Induced Changes: Experience from Tertiary Care Center Open
Hepatoblastoma is a rare pediatric liver tumor. Advances in imaging/surgical techniques and use of neoadjuvant chemotherapy (NACT) in recent times have resulted in improved survival of children with hepatoblastoma. Yet it has dismal progno…
View article: Analysing the clinical outcomes between FIGO 2009 and 2023 staging for endometrial cancer—a single institution retrospective study
Analysing the clinical outcomes between FIGO 2009 and 2023 staging for endometrial cancer—a single institution retrospective study Open
The latest International Federation of Gynaecology and Obstetrics (FIGO) staging for endometrial cancer incorporated molecular profiles and histopathological factors into the basic staging framework. This study was done to determine its im…
View article: Safety and Efficacy of Atezolizumab/Bevacizumab in unresectable Hepatocellular Carcinoma - a multicentric study
Safety and Efficacy of Atezolizumab/Bevacizumab in unresectable Hepatocellular Carcinoma - a multicentric study Open
Purpose: Immunotherapy with atezolizumab and bevacizumab is the current first-line standard of care for unresectable hepatocellular carcinoma (HCC). This study aimed to evaluate the safety and efficacy profile of atezolizumab-bevacizumab i…
View article: Economic burden of breast cancer in India, 2000–2021 and forecast to 2030
Economic burden of breast cancer in India, 2000–2021 and forecast to 2030 Open
Background Breast cancer represents a significant public health concern in India, accounting for 28% of all cancer diagnoses and imposing a substantial economic burden. This study introduces a novel approach to forecasting the number of br…
View article: Gigantic hip mass as the initial presentation of hyperphosphatemic familial tumoral calcinosis: A case report
Gigantic hip mass as the initial presentation of hyperphosphatemic familial tumoral calcinosis: A case report Open
Introduction: Hyperphosphatemic familial tumoural calcinosis (HFTC) is a rare autosomal recessive disorder characterised by ectopic calcium phosphate deposition around the joints due to mutations affecting phosphate regulation. Case outlin…
View article: Dengue Fever in Cancer Patients: A Case Series
Dengue Fever in Cancer Patients: A Case Series Open
Complications of dengue fever are understudied in oncology. In patients undergoing chemotherapy, the immunosuppressive effects of drugs increase susceptibility to infections, such as dengue, complicating diagnosis and treatment. Here, we r…
View article: Assessment of risk prediction scores for venous thromboembolism in ambulatory cancer patients with solid tumors receiving chemotherapy: A comparative analysis
Assessment of risk prediction scores for venous thromboembolism in ambulatory cancer patients with solid tumors receiving chemotherapy: A comparative analysis Open
Objective Cancer patients have a 4−7‐fold increased risk of thrombotic complications due to cancer as well as chemotherapy‐induced hypercoagulable state. This study compared the different risk assessment models (Khorana, PROTECHT, CONKO, a…
View article: Therapeutic Drug Monitoring of Sorafenib and Lenvatinib in Hepatocellular Carcinoma Patients – A Key to Personalised Pharmacotherapy
Therapeutic Drug Monitoring of Sorafenib and Lenvatinib in Hepatocellular Carcinoma Patients – A Key to Personalised Pharmacotherapy Open
Cancer remains a public concern and leading cause of death worldwide. Hepatocellular carcinoma, the most common form of liver cancer, is the third leading cause of cancer-related deaths. The number of cases is expected to double by 2040, a…
View article: Self-assembled Human Serum Protein-based Core-shell Nanoparticles to inhibit key oncogenic signalling in Drug-Resistant Leukemia
Self-assembled Human Serum Protein-based Core-shell Nanoparticles to inhibit key oncogenic signalling in Drug-Resistant Leukemia Open
Simultaneous inhibition of multiple oncogenic signaling pathways is crucial for managing refractory cancers. This study introduces two unique core-shell nanoparticle (CS-NP) systems crafted from natural proteins that simultaneously target…
View article: Immunohistochemical Subclassification of Peripheral T Cell Lymphomas-Not Otherwise Specified
Immunohistochemical Subclassification of Peripheral T Cell Lymphomas-Not Otherwise Specified Open
Peripheral T cell lymphomas-not otherwise specified (PTCL-NOS) are a heterogeneous group of mature T cell lymphomas that do not belong to any specified subtype. Gene expression profiling has revealed two biological variants of PTCL-NOS, PT…
View article: Effect of Warm Water Footbath Therapy on Fatigue Among Patients undergoing Hemodialysis
Effect of Warm Water Footbath Therapy on Fatigue Among Patients undergoing Hemodialysis Open
Chronic renal failure is a complex crippling condition influencing more than 70 million individuals around the world. Chronic Kidney disease has been recognized as a leading public health problem worldwide. Hemodialysis is essential to pro…