Pavle Zagorscak
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View article: Optimizing Expectations in an Internet- and mobile-based Intervention for Depression: Study Protocol for a Randomized Factorial Trial
Optimizing Expectations in an Internet- and mobile-based Intervention for Depression: Study Protocol for a Randomized Factorial Trial Open
Background: Expectations are considered an important mechanism of change in psychotherapeutic interventions, including Internet- and mobile-based interventions (IMI). This study aims to investigate whether two expectation-focused micro-int…
View article: Using the ICH estimand framework to improve the interpretation of treatment effects in internet interventions
Using the ICH estimand framework to improve the interpretation of treatment effects in internet interventions Open
The ICH E9(R1) Addendum on Estimands and Sensitivity Analysis provides a framework for defining the treatment effect a trial intends to estimate—the estimand. The addendum is widely adopted in pharmaceutical research. However, it remains u…
View article: How to report personalized Internet- and mobile- based intervention components: Introducing the ADAPT-I checklist
How to report personalized Internet- and mobile- based intervention components: Introducing the ADAPT-I checklist Open
Personalization of various Internet- and mobile-based intervention (IMI) components is common, but inconsistent terminology and selective reporting hinder research and practice. This paper introduces the Adjustable Content & Order, Dir…
View article: PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders
PREACT-digital: study protocol for a longitudinal, observational multicentre study on digital phenotypes of non-response to cognitive behavioural therapy for internalising disorders Open
Introduction Cognitive behavioural therapy (CBT) serves as a first-line treatment for internalising disorders (ID), encompassing depressive, anxiety or obsessive-compulsive disorders. Nonetheless, a substantial proportion of patients do no…
View article: A systematic review on personalization of treatment components in IBIs for mental disorders
A systematic review on personalization of treatment components in IBIs for mental disorders Open
View article: Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions
Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions Open
The ICH E9(R1) Addendum on Estimands and Sensitivity Analysis provides a rigorous framework for clearly defining the treatment effect a clinical trial aims to estimate—the so-called estimand. Although the addendum has been widely adopted i…
View article: Understanding the Unwanted: A Mixed-Methods Study on Negative Effects in an Internet-based Intervention for Depression
Understanding the Unwanted: A Mixed-Methods Study on Negative Effects in an Internet-based Intervention for Depression Open
Internet-based interventions (IBIs) are effective for treating depression, but they can also lead to negative effects in some participants. There is no consensus on which specific characteristics of negative effects clinicians and research…
View article: PREACT-digital: Study protocol for a longitudinal, observational multi-center study on wearable- and EMA- based predictors of non-response to CBT for internalizing disorders
PREACT-digital: Study protocol for a longitudinal, observational multi-center study on wearable- and EMA- based predictors of non-response to CBT for internalizing disorders Open
Introduction Despite CBT’s status as a first-line treatment, a substantial proportion of patients does not experience sufficient symptom relief. Recent advances in wearable technology and smartphone integration enable new, ecologically val…
View article: Is one additional phone call enough? - Effectiveness of additional human support to reduce dropout from an internet-based intervention for depressive symptoms: A randomized-controlled trial
Is one additional phone call enough? - Effectiveness of additional human support to reduce dropout from an internet-based intervention for depressive symptoms: A randomized-controlled trial Open
View article: Systematic Review on the Effects of Personalization of Treatment Components in Internet-based Interventions for Mental Disorders
Systematic Review on the Effects of Personalization of Treatment Components in Internet-based Interventions for Mental Disorders Open
Background: Internet-based interventions (IBIs) offer the potential for personalization through various mechanisms and components. Objective: This systematic review aimed to synthesize evidence on the personalization of treatment component…
View article: A randomized controlled trial of a therapist-guided online intervention for depressed adults and its utility as an adjunctive to antidepressants and psychotherapy
A randomized controlled trial of a therapist-guided online intervention for depressed adults and its utility as an adjunctive to antidepressants and psychotherapy Open
Background Internet-based interventions (IBIs) are a low-threshold treatment for individuals with depression. However, comparisons of IBI against unstandardized care-as-usual (CAU) are scarce. Moreover, little evidence is available if IBI …
View article: Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions
Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions Open
Randomized controlled trials are the gold standard for evaluating internet-based interventions (IBIs). However, their value depends on whether the estimated treatment effect accurately reflects its intended meaning. Unfortunately, this is …
View article: Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions
Give Your Treatment Effect a Meaning: Applying the ICH E9 (R1) Estimand Framework to Internet-based Interventions Open
Randomized controlled trials are the gold standard for evaluating internet-based interventions (IBIs). However, their value depends on whether the estimated treatment effect accurately reflects its intended meaning. Unfortunately, this is …
View article: Is one additional phone call enough? - Effectiveness of additional human support to reduce dropout from an internet-based intervention for depressive symptoms: a randomized-controlled trial.
Is one additional phone call enough? - Effectiveness of additional human support to reduce dropout from an internet-based intervention for depressive symptoms: a randomized-controlled trial. Open
Background. Internet-Based Interventions (IBIs) are effective treatments for mental disorders, but their implementation faces challenges, particularly in addressing high dropout rates. Adding more human support or guidance might reduce tre…
View article: Select or adjust? How information from early treatment stages boosts the prediction of non-response in internet-based depression treatment
Select or adjust? How information from early treatment stages boosts the prediction of non-response in internet-based depression treatment Open
Background Internet-based interventions produce comparable effectiveness rates as face-to-face therapy in treating depression. Still, more than half of patients do not respond to treatment. Machine learning (ML) methods could help to overc…
View article: Increasing the effectiveness of psychotherapy in routine care through blended therapy with transdiagnostic online modules (PsyTOM): study protocol for a randomized controlled trial
Increasing the effectiveness of psychotherapy in routine care through blended therapy with transdiagnostic online modules (PsyTOM): study protocol for a randomized controlled trial Open
Background In blended therapy, face-to-face psychotherapy and Internet-based interventions are combined. Blended therapy may be advantageous for patients and psychotherapists. However, most blended interventions focus on cognitive behavior…
View article: Mind the context—The relevance of personality for face-to-face and computer-mediated communication
Mind the context—The relevance of personality for face-to-face and computer-mediated communication Open
A large body of research has examined the link between personality and face-to-face (FtF) communication knowledge, skills, abilities, and other characteristics (KSAOs). With the rise of digital media, text-based computer-mediated (CM) comm…
View article: Increasing the Effectiveness of Psychotherapy in Routine Care through Blended Therapy with Transdiagnostic Online Modules (PsyTOM): Study Protocol for a Randomized Controlled Trial
Increasing the Effectiveness of Psychotherapy in Routine Care through Blended Therapy with Transdiagnostic Online Modules (PsyTOM): Study Protocol for a Randomized Controlled Trial Open
Background: In blended therapy, face-to-face psychotherapy and Internet-based interventionsare combined. Blended therapy may be advantageous for patients and psychotherapists.However, most blended interventions focus on cognitive behaviora…
View article: On the Meaning of the “<i>P</i> Factor” in Symmetrical Bifactor Models of Psychopathology: Recommendations for Future Research From the Bifactor-(<i>S</i>−1) Perspective
On the Meaning of the “<i>P</i> Factor” in Symmetrical Bifactor Models of Psychopathology: Recommendations for Future Research From the Bifactor-(<i>S</i>−1) Perspective Open
Symmetrical bifactor models are frequently applied to diverse symptoms of psychopathology to identify a general P factor. This factor is assumed to mark shared liability across all psychopathology dimensions and mental disorders. Despite t…
View article: Negative effects in internet-based interventions for depression: A qualitative content analysis
Negative effects in internet-based interventions for depression: A qualitative content analysis Open
View article: Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data
Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data Open
View article: Internet-Based Cognitive Behavioral Therapy for Depression
Internet-Based Cognitive Behavioral Therapy for Depression Open
Importance Personalized treatment choices would increase the effectiveness of internet-based cognitive behavioral therapy (iCBT) for depression to the extent that patients differ in interventions that better suit them. Objective To provide…
View article: On the Meaning of the General Factor of Psychopathology (“P-Factor”) in Symmetrical Bifactor Models
On the Meaning of the General Factor of Psychopathology (“P-Factor”) in Symmetrical Bifactor Models Open
Symmetrical bifactor models are frequently applied to diverse symptoms of psychopathology to identify a general P factor. This factor is assumed to mark shared liability across psychopathology dimensions and mental disorders. Despite their…
View article: Mechanisms of Change in Internet-Based Interventions for Depression
Mechanisms of Change in Internet-Based Interventions for Depression Open
Unipolar depression ranks first on the World Health Organization’s list of diseases responsible for global health burden. Different approaches of pharmacotherapy and face-to-face psychotherapy have been proven efficacious in reducing sympt…
View article: How individuals change during internet‐based interventions for depression: A randomized controlled trial comparing standardized and individualized feedback
How individuals change during internet‐based interventions for depression: A randomized controlled trial comparing standardized and individualized feedback Open
Background Standardized and individualized Internet‐based interventions (IBI) for depression yield significant symptom improvements. However, change patterns during standardized or individualized IBI are unknown. Identifying subgroups that…
View article: Only on Invitation? How the Recruitment Strategy Determines Who Is Treated Online
Only on Invitation? How the Recruitment Strategy Determines Who Is Treated Online Open
Background: Participants for efficacy studies on Internet-based interventions (IBI) are recruited through self-selected convenience sampling or targeted external invitations. Comparisons are necessary to determine how recruitment strategie…
View article: Supplementary Material for: Benefits of Individualized Feedback in Internet-Based Interventions for Depression: A Randomized Controlled Trial
Supplementary Material for: Benefits of Individualized Feedback in Internet-Based Interventions for Depression: A Randomized Controlled Trial Open
Background: Even though there is an increasing number of studies on the efficacy of Internet-based interventions (IBI) for depression, experimental trials on the benefits of added guidance by clinicians are scarce and inconsi…