Pawan Poudel
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View article: Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring
Exploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring Open
Tertiary Lymphoid Structures (TLS) are lymphoid structures commonly associated with improved survival of cancer patients and response to immunotherapies. However, conflicting reports underscore the need to consider TLS heterogeneity and mu…
View article: Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1
Nutrient profiling reveals extracellular uridine as a fuel for pancreatic cancer through uridine phosphorylase 1 Open
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease characterized by high invasiveness, therapeutic resistance, and metabolic aberrations. Although altered metabolism drives PDA growth and survival, the complete spectrum of metaboli…
View article: Metadata supporting data files of the related article: Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses
Metadata supporting data files of the related article: Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses Open
In this study, the authors investigated the heterogeneity of luminal-A breast cancers based on heterocellular gene signatures. The aim was to stratify luminal-A breast cancer samples according to well-characterised and cancer-associated he…
View article: A Novel Statistical Method to Diagnose, Quantify and Correct Batch Effects in Genomic Studies
A Novel Statistical Method to Diagnose, Quantify and Correct Batch Effects in Genomic Studies Open
Genome projects now generate large-scale data often produced at various time points by different laboratories using multiple platforms. This increases the potential for batch effects. Currently there are several batch evaluation methods li…
View article: Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer Samples into Molecular Subtypes
Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer Samples into Molecular Subtypes Open
Previously, we classified colorectal cancers (CRCs) into five CRCA subtypes with different prognoses and potential treatment responses, using a 786-gene signature. We merged our subtypes and those described by five other groups into four c…
View article: A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders
A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders Open
Key Points Developed a targeted sequencing platform covering 63 genes linked to heritable bleeding, thrombotic, and platelet disorders. The ThromboGenomics platform provides a sensitive genetic test to obtain molecular diagnoses in patient…