Explanipedia

Evaluating the Role of Andexanet Alfa in Managing Intracranial Hemorrhage in Patients on Vascular-Dose Rivaroxaban: A Clinical Dilemma Open

Matija Zupan, Pawel Kermer, Senta Frol · 2025

Tenecteplase—What Have We Learned till Now? A Narrative Review Open

Matija Zupan, Lara Straus, Pawel Kermer, Senta Frol · 2025

Tenecteplase (TNK), a genetically modified tissue plasminogen activator, has emerged as a promising alternative to alteplase (ALT) for intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Our aim was to synthesize the current cli…

Intravenous Thrombolysis in Patients With Recent Intake of Direct Oral Anticoagulants: A Target Trial Analysis and Comparison With Reversal Agent Use Open

Thomas R. Meinel, Philipp Buecke, Lucio D’Anna, Giovanni Merlino, Diana Aguiar de Sousa , et al. · 2025

BACKGROUND: Intravenous thrombolysis (IVT) in patients with recent ingestion of direct oral anticoagulants (DOACs) is a frequent challenge and remains controversial. The benefit of DOAC reversal before IVT is uncertain. METHODS: Using targ…

Intravenous thrombolysis before endovascular treatment in acute posterior circulation occlusions, what's next? Open

Senta Frol, Matija Zupan, Panagiotis Papanagiotou, Pawel Kermer · 2025

Baseline characteristics of patients with acute ischaemic stroke included in the randomised controlled Find-AF 2 trial Open

Katrin Wasser, Tobias Uhe, Wolf-Rüdiger Schäbitz, Martin Köhrmann, Martin Dichgans , et al. · 2025

Background In the Find-AF 2 randomised controlled trial, we investigate whether a risk-adapted intensified heart rhythm monitoring with subsequent initiation of oral anticoagulation in ischaemic stroke patients leads to a reduction of recu…

Association of oral anticoagulants with risk of brain haemorrhage expansion compared to no-anticoagulation Open

Roland Veltkamp, Kirsten Haas, Viktoria Rücker, Uwe Malzahn, Allen Heeger , et al. · 2025

Background The impact of direct oral anticoagulants (DOAC) on haematoma size after intracerebral haemorrhage (ICH) compared to no-anticoagulation is controversial and prospective data are lacking. Methods The investigator-initiated, multic…

Higher efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants—A new relevant hypothesis Open

Senta Frol, Janja Pretnar Oblak, Pawel Kermer, George Ntaios, Panagiotis Papanagiotou , et al. · 2024

Idarucizumab in dabigatran-treated patients with acute stroke: a review and clinical update Open

Senta Frol, Janja Pretnar Oblak, Mišo Šabovič, George Ntaios, Pawel Kermer · 2024

Idarucizumab is an antibody fragment specific for the immediate reversal of dabigatran anticoagulation effects. The use of idarucizumab is approved for dabigatran-treated patients suffering from life-threatening or uncontrolled bleeding an…

Correction to: Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management Open

Tania Kümpfel, Katrin Giglhuber, Orhan Aktaş, Ilya Ayzenberg, Judith Bellmann‐Strobl , et al. · 2024

Andexanet Alfa: What We Have Learned from Clinical Trials and Real-World Data Open

Senta Frol, Janja Pretnar Oblak, Mišo Šabović, Pawel Kermer · 2024

Andexanet alfa is a specific reversal agent for factor Xa inhibitors with immediate reversal of their anticoagulant effect. Andexanet alfa is currently approved for use in patients treated with rivaroxaban and apixaban who have life-threat…

Specific Reversal Agents for Direct Oral Anticoagulants in Acute Stroke Open

Senta Frol, Janja Pretnar Oblak, Mišo Šabović, Wim H. van Zwam, George Ntaios , et al. · 2024

Direct oral anticoagulants (DOACs) changed stroke prevention and decreased the risk of ischemic and hemorrhagic complications in patients on oral anticoagulation (OAC) therapy. The numbers of patients prescribed DOACs has increased rapidly…

Treatment of Acute Ischaemic Stroke and Concomitant Multiple Arterial Splanchnic Thromboses in a Patient with Immune Thrombocytopenia on Thrombopoietin Agonist: A Case Report Open

Senta Frol, Janja Pretnar Oblak, Mišo Šabović, Pawel Kermer, Matjaž Sever · 2023

Immune thrombocytopenia (ITP) is an autoimmune blood disorder characterised by isolated severe thrombocytopenia. Arterial thrombotic events, such as acute ischaemic stroke (AIS), are rare complications. A 56-year-old woman with chronic ITP…

Update on the diagnosis and treatment of neuromyelitis optica spectrum disorders (NMOSD) – revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part II: Attack therapy and long-term management Open

Tania Kümpfel, Katrin Giglhuber, Orhan Aktaş, Ilya Ayzenberg, Judith Bellmann‐Strobl , et al. · 2023

Intensive heart rhythm monitoring to decrease ischemic stroke and systemic embolism—the Find-AF 2 study—rationale and design Open

Tobias Uhe, Katrin Wasser, Mark Weber-Krüger, Wolf‐Rüdiger Schäbitz, Martin Köhrmann , et al. · 2023

The Find-AF 2 trial aims to demonstrate that enhanced, prolonged and intensified rhythm monitoring results in a more effective prevention of recurrent ischemic stroke and systemic embolism compared to usual care.

Final Study Report of Andexanet Alfa for Major Bleeding With Factor Xa Inhibitors Open

Truman J. Milling, Saskia Middeldorp, Lizhen Xu, Bruce Koch, Andrew M. Demchuk , et al. · 2023

Background: Andexanet alfa is a modified recombinant inactive factor Xa (FXa) designed to reverse FXa inhibitors. ANNEXA-4 (Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of Factor Xa Inhibitors) was a multicenter, prospec…

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants Open

Thomas R. Meinel, Duncan Wilson, Henrik Gensicke, Jan F. Scheitz, Peter A. Ringleb , et al. · 2023

Importance International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of a direct oral anticoagulant (DOAC). Objective To determine the risk of symptomatic intracran…

Acute adverse events of Sars-CoV2 vaccines: Experiences from a health care worker vaccination campaign in two municipal hospitals in northwest Germany Open

Pawel Kermer, Yasser Abdalla, Guido Klein, Claus Lüers · 2022

Vaccination is considered the best measure to overcome the Sars-Cov2 pandemic. However, changing national recommendations on sequence and time frame necessitate the collection of real-word data on adverse events of Sars-CoV2 vaccination pr…

SOP: thrombolysis in ischemic stroke under oral anticoagulation therapy Open

Pawel Kermer, Peter D. Schellinger, Peter A. Ringleb, Martin Köhrmann · 2022

Belly Dancer’s Dyskinesia: 3 Cases of a Rare Entity Open

Kristina Rathmann, Jens Hambach, Nataliia Meleshchenko, Reinhard Rohkamm, Pawel Kermer · 2022

Involuntary, undulating, or circular movements of abdominal wall muscles are a rare condition descriptively termed belly dancer syndrome or belly dancer’s dyskinesia. Differential diagnoses range from cerebral, spinal, peripheral, hormonal…

Supplementary Material for: Belly Dancer’s Dyskinesia: 3 Cases of a Rare Entity Open

Kristina Rathmann, Jens Hambach, Nataliia Meleshchenko, Reinhard Rohkamm, Pawel Kermer · 2022

Involuntary, undulating, or circular movements of abdominal wall muscles are a rare condition descriptively termed belly dancer syndrome or belly dancer’s dyskinesia. Differential diagnoses range from cerebral, spinal, peripheral, hormonal…

Long-Term Follow-up of Enhanced Holter-Electrocardiography Monitoring in Acute Ischemic Stroke Open

Rolf Wachter, Mark Weber-Krüger, Gerhard F. Hamann, Pawel Kermer, Jan Liman , et al. · 2021

Background and Purpose Prolonged electrocardiography (ECG)-monitoring in stroke patients improves the detection of paroxysmal atrial fibrillation (pAF). However, most randomized studies only had short follow-up. We aimed to provide 3-year …

Autoantibodies Against the Purkinje Cell Protein RGS8 in Paraneoplastic Cerebellar Syndrome Open

Ramona Miske, Madeleine Scharf, Patrick Stark, Heiko Dietzel, Corinna Bien , et al. · 2021

This study provided Class IV evidence that autoantibodies against the intracellular Purkinje cell protein RGS8 are associated with paraneoplastic cerebellar syndrome in lymphoma.

Health-related quality of life, anxiety and depression up to 12 months post-stroke: Influence of sex, age, stroke severity and atrial fibrillation – A longitudinal subanalysis of the Find-AFRANDOMISED trial Open

Monika Sadlonova, Katrin Wasser, Jonas Nagel, Mark Weber-Krüger, Sonja Gröschel , et al. · 2021

Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01855035.

BAG1 Overexpression Stabilizes High Molecular Tau Protein – a Crucial Role of the Co-chaperone in Tau Pathology Open

Sandra C. Signore, Fred S. Wouters, Matthias Schmitz, Mathias Baehr, Pawel Kermer · 2021

The Bcl-2-associated athanogene-1 (BAG1) exerts neuroprotective properties which has been shown in several studies of neurodegenerative disease models like Parkinson’s disease, Huntington’s disease and even cerebral ischemia. On the basis …

Brain Natriuretic Peptide and Discovery of Atrial Fibrillation After Stroke Open

Katrin Wasser, Mark Weber-Krüger, Sonja Gröschel, Timo Uphaus, Jan Liman , et al. · 2019

Background and Purpose— Diagnosing paroxysmal atrial fibrillation (pAF) can be challenging after acute ischemic stroke. Enhanced and prolonged Holter-ECG monitoring (EPM) improves the detection rate but is not feasible for all patients. We…

Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders Open

Marius Ringelstein, Jens Harmel, Hanna Zimmermann, Alexander U. Brandt, Friedemann Paul , et al. · 2019

This first longitudinal VEP study of patients with NMOSD provides evidence of progressive VEP latency delay occurring independently of acute ON. Prospective longitudinal studies are needed to corroborate these findings and help to interpre…

Global Use of Idarucizumab in Clinical Practice: Outcomes of the RE-VECTO Surveillance Program Open

John Fanikos, Debra Murwin, Fredrik Gruenenfelder, Igor Tartakovsky, Lionel Riou França , et al. · 2019

Idarucizumab was approved for the reversal of dabigatran in 2015. We investigated whether postapproval usage patterns of idarucizumab in a real-world setting reflect those observed in the pivotal trials. No safety or efficacy data were col…

Economic evaluation of prolonged and enhanced ECG Holter monitoring in acute ischemic stroke patients Open

Sandra Diekmann, L Hörster, Silvia Evers, Mickaël Hiligsmann, Götz Gelbrich , et al. · 2019

Objective: Atrial fibrillation (AF) is a major cause for recurrent stroke, has severe impact on a patient's health and imposes a high economic burden for society. Current guidelines recommend 24 h ECG monitoring (standard-of-care, S…

The cardiac diagnostic work-up in stroke patients—A subanalysis of the Find-AFRANDOMISED trial Open

Katrin Wasser, Mark Weber-Krüger, Falko Jürries, Jan Liman, Gerhard F. Hamann , et al. · 2019

ClinicalTrials.gov NCT01855035.

Apheresis therapies for NMOSD attacks Open

Ingo Kleiter, Anna Gahlen, Nadja Borisow, Katrin Fischer, Klaus‐Dieter Wernecke , et al. · 2018

This study provides Class IV evidence that for patients with NMOSD, neither PE nor IA is superior in the treatment of attacks.

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