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Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells Open

Liliana M. Sanmarco, Joseph M. Rone, Carolina Manganeli Polonio, Gonzalo Fernandez Lahore, Federico Giovannoni , et al. · 2023

Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells Open

Liliana M. Sanmarco, Joseph M. Rone, Carolina Manganeli Polonio, Federico Giovannoni, Gonzalo Fernandez Lahore , et al. · 2023

Summary Dendritic cells (DCs) control the generation of self-reactive pathogenic T cells. Thus, DCs are considered attractive therapeutic targets for autoimmune diseases. Using single-cell and bulk transcriptional and metabolic analyses in…