Pankaj Kumar Singh
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View article: Tailoring Anticoagulant Therapy: Managing Interactions Between Carbamazepine and Direct Oral Anticoagulants (DOACs)
Tailoring Anticoagulant Therapy: Managing Interactions Between Carbamazepine and Direct Oral Anticoagulants (DOACs) Open
View article: Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes
Designing fluorescent estrogen mimetic 7-hydroxycoumarin probe substrates for human sulfotransferase enzymes Open
Sulfonation is one of drug metabolism reactions affecting homeostasis of estrogens. C-3 aryl substituted 7-hydroxycoumarins are fluorescent estrogen mimetics; i.e., the hydroxyl groups of both estrogens and 7-hydroxycoumarins are conjugate…
View article: Estimation Of Human Stature From Footprint Dimension And Foot Outline Dimension In Uttar Pradesh, India
Estimation Of Human Stature From Footprint Dimension And Foot Outline Dimension In Uttar Pradesh, India Open
View article: Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo
Anticancer activity of RM-3-22: a TAZQ-based hydroxamic acid derivative targeting NSCLC in vitro and in vivo Open
Introduction Lung cancer remains the leading cause of cancer-related deaths, necessitating novel therapeutic strategies. In this study, we developed RM-3-22, a TAZQ-based hydroxamic acid derivative with histone deacetylase (HDAC) inhibitor…
View article: Nanoformulation-based medicines for the treatment of reactive oxygen species-induced diseases: A review
Nanoformulation-based medicines for the treatment of reactive oxygen species-induced diseases: A review Open
Reactive oxygen species (ROS), are highly reactive molecules formed as a natural by-product during cellular metabolism primarily within the mitochondrial matrix. Excessive production of ROS may cause serious illnesses like cardiovascular d…
View article: Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development
Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development Open
View article: Correlation and path coefficient analysis for yield and it’s components traits in chickpea (Cicer arietinum L.)
Correlation and path coefficient analysis for yield and it’s components traits in chickpea (Cicer arietinum L.) Open
View article: Genetic association and direct-indirect effects of yield components in chickpea (Cicer arietinum L.): A correlation and path coefficient study
Genetic association and direct-indirect effects of yield components in chickpea (Cicer arietinum L.): A correlation and path coefficient study Open
View article: Genetic diversity study in genotypes of aromatic rice (Oryza sativa L.)
Genetic diversity study in genotypes of aromatic rice (Oryza sativa L.) Open
View article: Agro-morphological characterization of aromatic genotypes of rice (Oryza sativa L.)
Agro-morphological characterization of aromatic genotypes of rice (Oryza sativa L.) Open
View article: Current Status of Multi Drug Resistance- Tuberculosis: A Major Public-Health Threat
Current Status of Multi Drug Resistance- Tuberculosis: A Major Public-Health Threat Open
Background: Rifampicin is the most effective first-line antibiotic for tuberculosis (TB). However, drug resistance, particularly multidrug-resistant TB (MDR-TB), poses a significant global health challenge. According to the World Health Or…
View article: Leptospirosis And Brucellosis Mixed Cluster Investigation In A Rural Pastoral Community Of Dairy Farmers In Uttarakhand, India, 2023-2024
Leptospirosis And Brucellosis Mixed Cluster Investigation In A Rural Pastoral Community Of Dairy Farmers In Uttarakhand, India, 2023-2024 Open
Background Leptospirosis and Brucellosis are bacterial zoonoses prevalent in South-East-Asia. We investigated a case-cluster of these diseases reported in October 2023 from Ward X, Uttarakhand, India, identified through a One-health camp, …
View article: Referee report. For: Molecular docking studies and molecular dynamic simulation analysis: To identify novel ATP-competitive inhibition of Glycogen synthase kinase-3β for Alzheimer’s disease [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved]
Referee report. For: Molecular docking studies and molecular dynamic simulation analysis: To identify novel ATP-competitive inhibition of Glycogen synthase kinase-3β for Alzheimer’s disease [version 2; peer review: 1 approved, 1 approved with reservations, 1 not approved] Open
View article: Root Dentin Transparency: A Reliable Method of Age Estimation in Nepalese Population
Root Dentin Transparency: A Reliable Method of Age Estimation in Nepalese Population Open
Background: Root dentin transparency, one of the age changes in dentin, is considered to be a stable parameter not affected by environmental and pathological factors. The effect of age changes in the transparency of root dentin in Nepalese…
View article: Oxazolidinones: Are they only good for the discovery of antibiotics? A worm's eye view
Oxazolidinones: Are they only good for the discovery of antibiotics? A worm's eye view Open
Oxazolidinones are one of the well-known classes of O-heterocycles which has yielded various potent antibiotics. Several oxazolidinone-based antibiotics are either FDA-approved or are in clinical trials. They act via competitively binding …
View article: Supplementary Figure 3 from Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis
Supplementary Figure 3 from Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis Open
PDF file - 1974K, In vivo glucose uptake in orthotopic tumors of Capan1 Scr and Capan1 Ecd KD cell injected mice
View article: Supplementary Figure 2 from Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer
Supplementary Figure 2 from Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer Open
PDF file - 404K
View article: Data from Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras
Data from Cyclin-Dependent Kinase 5 Is Amplified and Overexpressed in Pancreatic Cancer and Activated by Mutant K-Ras Open
Purpose: To evaluate the nature of cyclin-dependent kinase 5 (CDK5) hyperactivity in pancreatic cancer progression.Experimental Design: We used genetic, biochemical, and molecular biology methods to investigate the nature and…
View article: Supplementary Figure 2 from Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis
Supplementary Figure 2 from Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis Open
PDF file - 1831K, Variation in GLUT4 expression in Scrambled vs. Ecd KD pancreatic cancer cells. (A) Reduction in GLUT4 protein and mRNA level on Ecd depletion
View article: Identification of natural peptides from “PlantPepDB” database as anti-SARS-CoV-2 agents: A protein-protein docking approach
Identification of natural peptides from “PlantPepDB” database as anti-SARS-CoV-2 agents: A protein-protein docking approach Open
View article: Supplementary Data from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Supplementary Data from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer Open
Supplemental Figure 3. Combination inhibition of YAP1 and CDK6 eradicate CSCs population in radiation resistant cells A&B.
View article: Supplementary Figure 2 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Supplementary Figure 2 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer Open
Supplemental Figure 2. Association of YAP1 and CDK6 in chemo/radiation resistant tissues and cells.
View article: Data from <i>De Novo</i> Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer
Data from <i>De Novo</i> Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer Open
Pancreatic adenocarcinoma is moderately responsive to gemcitabine-based chemotherapy, the most widely used single-agent therapy for pancreatic cancer. Although the prognosis in pancreatic cancer remains grim in part due to poor response to…
View article: Supplementary Figure 2 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Supplementary Figure 2 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer Open
Supplemental Figure 2. Association of YAP1 and CDK6 in chemo/radiation resistant tissues and cells.
View article: Supplementary Figure 4 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Supplementary Figure 4 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer Open
Supplemental Figure 4. Anti-tumor effects of combination inhibition of YAP1 and CDK6 as well as radiation therapy in mice bearing radiation resistant tumors.
View article: Supplementary Data from Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
Supplementary Data from Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer Open
Supplementary Data from Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer
View article: Supplementary Figure 4 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer
Supplementary Figure 4 from YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer – Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer Open
Supplemental Figure 4. Anti-tumor effects of combination inhibition of YAP1 and CDK6 as well as radiation therapy in mice bearing radiation resistant tumors.
View article: Energy decomposition and waterswapping analysis to investigate the SNP associated DPD mediated 5-FU resistance
Energy decomposition and waterswapping analysis to investigate the SNP associated DPD mediated 5-FU resistance Open
5-fluorouracil is an essential component of systemic chemotherapy for colon, breast, head, and neck cancer patients. However, tumoral overexpression of the dihydropyrimidine dehydrogenase has rendered 5-FU clinically ineffective by inactiv…
View article: Dihydropyrimidine Dehydrogenase-Mediated Resistance to 5-Fluorouracil: Mechanistic Investigation and Solution
Dihydropyrimidine Dehydrogenase-Mediated Resistance to 5-Fluorouracil: Mechanistic Investigation and Solution Open
5-Fluorouracil (5-FU) is one of the most widely used chemotherapeutics for the treatment of cancers associated with the aerodigestive tract, breast, and colorectal system. The efficacy of 5-FU is majorly affected by dihydropyrimidine dehyd…
View article: Network Analysis Guided Designing of Multi-Targeted Anti-Fungal Agents: Synthesis and Biological Evaluation
Network Analysis Guided Designing of Multi-Targeted Anti-Fungal Agents: Synthesis and Biological Evaluation Open