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View article: Correction: Healthcare-seeking behaviour of fever cases in Magude district, southern Mozambique: A qualitative study
Correction: Healthcare-seeking behaviour of fever cases in Magude district, southern Mozambique: A qualitative study Open
[This corrects the article DOI: 10.1371/journal.pone.0323117.].
View article: Making the most of existing antimalarial medicines: a single dose cure with sulfadoxine–pyrimethamine plus artesunate–pyronaridine
Making the most of existing antimalarial medicines: a single dose cure with sulfadoxine–pyrimethamine plus artesunate–pyronaridine Open
View article: Antimalarial drug resistance and population structure of Plasmodium falciparum in Mozambique using genomic surveillance at health facilities in 2021 and 2022
Antimalarial drug resistance and population structure of Plasmodium falciparum in Mozambique using genomic surveillance at health facilities in 2021 and 2022 Open
Monitoring the emergence and spread of drug-resistant parasites is essential for effective malaria control. Here, we describe the prevalence of genetic markers of Plasmodium falciparum antimalarial drug resistance and parasite population s…
View article: Author response: Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns
Author response: Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns Open
View article: Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns
Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns Open
Imported malaria is a critical obstacle to achieving elimination in low transmission settings. Characterising malaria importation and transmission sources using human mobility and parasite genomics has the potential to inform elimination s…
View article: Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns
Estimating probabilities of malaria importation in southern Mozambique through P. falciparum genomics and mobility patterns Open
Imported malaria is a critical obstacle to achieving elimination in low transmission settings. Characterising malaria importation and transmission sources using human mobility and parasite genomics has the potential to inform elimination s…
View article: Efficacy of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in Mozambique, 2022
Efficacy of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in Mozambique, 2022 Open
Clinicaltrials.gov: NCT05343312.
View article: Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples
Pf8: an open dataset of Plasmodium falciparum genome variation in 33,325 worldwide samples Open
We describe the Pf8 data resource, the latest MalariaGEN release of curated genome variation data on over 33,000 Plasmodium falciparum samples from 99 partner studies and 122 locations over more than 50 years. This release provides open a…
View article: Healthcare-seeking behaviour of fever cases in Magude district, southern Mozambique: A qualitative study
Healthcare-seeking behaviour of fever cases in Magude district, southern Mozambique: A qualitative study Open
Fever is the main manifestation of malaria, which is a major public health concern in Mozambique. Achieving prompt diagnosis and appropriate management of all malaria cases is key to avoiding severe malaria and death, thus communities need…
View article: Estimating probabilities of malaria importation in southern Mozambique through <i>P. falciparum</i> genomics and mobility patterns
Estimating probabilities of malaria importation in southern Mozambique through <i>P. falciparum</i> genomics and mobility patterns Open
Imported malaria is a critical obstacle to achieving elimination in low transmission settings. Characterising malaria importation and transmission sources using human mobility and parasite genomics has the potential to inform elimination s…
View article: Host biomarkers and parasite biomass are associated with severe malaria in Mozambican children: a case–control study
Host biomarkers and parasite biomass are associated with severe malaria in Mozambican children: a case–control study Open
Severe pediatric malaria remains a pressing global health issue. Laboratory parameters may provide early risk and severity stratification for better disease management, beyond current clinical severity scores. This study aimed to identify …
View article: Phase one of a hybrid effectiveness-implementation study to assess the feasibility, acceptability and effectiveness of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique
Phase one of a hybrid effectiveness-implementation study to assess the feasibility, acceptability and effectiveness of implementing seasonal malaria chemoprevention in Nampula Province, Mozambique Open
View article: Paediatric healthcare in Manhiça district through a gender lens: a retrospective analysis of 17 years of morbidity and demographic surveillance data
Paediatric healthcare in Manhiça district through a gender lens: a retrospective analysis of 17 years of morbidity and demographic surveillance data Open
Girls had fewer referrals and admissions to hospital in Manhiça district, but they were also less likely to present with severe manifestations. Other studied indicators of healthcare access and provision were overall similar for boys and g…
View article: The epidemiology of malaria in four districts in southern Mozambique receiving indoor residual spray as part of a cross-border initiative
The epidemiology of malaria in four districts in southern Mozambique receiving indoor residual spray as part of a cross-border initiative Open
The study revealed that IRS implementation decreased malaria prevalence in Inharrime and Panda but not in Guija and Zavala. To ensure that cross-border movement of people does not result in increased malaria transmission, targeting areas i…
View article: Randomized trial of BCG in healthcare workers to reduce absenteeism during the COVID-19 pandemic in sub-Saharan Africa
Randomized trial of BCG in healthcare workers to reduce absenteeism during the COVID-19 pandemic in sub-Saharan Africa Open
Background We tested whether providing BCG vaccine to healthcare workers (HCWs) could reduce non-planned absenteeism and thereby reduce the potential impact of the COVID-19 pandemic on healthcare systems in Africa. Methods We conducted a m…
View article: Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children
Effect of RTS,S/AS01E vaccine booster dose on cellular immune responses in African infants and children Open
RTS,S/AS01(E), the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunization and now report …
View article: The effect of the RTS,S/AS01E vaccine booster dose on cell-mediated immune responses in African infants and children
The effect of the RTS,S/AS01E vaccine booster dose on cell-mediated immune responses in African infants and children Open
RTS,S/AS01E, the first approved malaria vaccine, demonstrated moderate efficacy during the phase 3 pediatric trial. We previously investigated cell-mediated immune (CMI) responses following the primary 3-dose immunizations and now report r…
View article: An evaluation of LLIN physical integrity and population attitudes towards net use, care and handling during the Magude project in southern Mozambique
An evaluation of LLIN physical integrity and population attitudes towards net use, care and handling during the Magude project in southern Mozambique Open
Background The Magude Project assessed the feasibility of eliminating malaria in Magude district, a low transmission setting in southern Mozambique, using a package of interventions, including long-lasting insecticidal nets (LLINs). As the…
View article: Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique
Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique Open
View article: Results from phase one of a hybrid effectiveness-implementation study to assess the feasibility, acceptability and effectiveness of implementing seasonal malaria chemoprevention in Nampula province, Mozambique
Results from phase one of a hybrid effectiveness-implementation study to assess the feasibility, acceptability and effectiveness of implementing seasonal malaria chemoprevention in Nampula province, Mozambique Open
Introduction Seasonal malaria chemoprevention (SMC) is a highly effective intervention for malaria prevention in high burden areas with seasonal transmission, historically implemented in the Sahel. Mozambique contributes to 4% of global ma…
View article: PA-378 Implementation research outcomes of a programmatic mass drug administration campaign for malaria in southern Mozambique: results from a community and health staff survey
PA-378 Implementation research outcomes of a programmatic mass drug administration campaign for malaria in southern Mozambique: results from a community and health staff survey Open
Background Mass Drug Administration for malaria consists of administering antimalarial drugs to the whole population in a defined area, irrespective of infection status. The World Health Organization recommends it to reduce transmission in…
View article: PA-785 Characterization of anti-SARS-CoV-2 humoral immunity among health care workers in hospitals from the islands of Santiago and São Vicente, Cabo Verde
PA-785 Characterization of anti-SARS-CoV-2 humoral immunity among health care workers in hospitals from the islands of Santiago and São Vicente, Cabo Verde Open
Background Health Care Workers (HCW) faced a high risk of exposure to SARS-CoV-2. In the present study, we described the presence and duration of anti-S and anti-N IgG antibodies against SARS-CoV-2 among HCW to evaluate the immunity respon…
View article: PA-375 Feasibility of a programmatic mass drug administration campaign for malaria in Southern Mozambique
PA-375 Feasibility of a programmatic mass drug administration campaign for malaria in Southern Mozambique Open
Background Malaria Mass Drug Administration (MDA) is recommended to reduce malaria in low transmission settings, with a target coverage of ≥80%. This study assesses the feasibility of a programmatic MDA (pMDA) pilot implementation in south…
View article: PA-494 Socioeconomic determinants of early health care utilisation and association with malaria hospitalisation among under five years children in Manhiça, Mozambique
PA-494 Socioeconomic determinants of early health care utilisation and association with malaria hospitalisation among under five years children in Manhiça, Mozambique Open
Background Malaria is one of the significant health problems in the world, and the greatest burden of the disease is concentrated in Africa, which accounts for about 95% of cases. The World Health Organization indicates that early seeking …
View article: Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique
Genomic malaria surveillance of antenatal care users detects reduced transmission following elimination interventions in Mozambique Open
Routine sampling of pregnant women at first antenatal care (ANC) visits could make Plasmodium falciparum genomic surveillance more cost-efficient and convenient in sub-Saharan Africa. We compared the genetic structure of parasite populatio…
View article: Prescription patterns and compliance with World Health Organization recommendations for the management of uncomplicated and severe malaria: A prospective, real-world study in sub-Saharan Africa
Prescription patterns and compliance with World Health Organization recommendations for the management of uncomplicated and severe malaria: A prospective, real-world study in sub-Saharan Africa Open
View article: Detecting temporal and spatial malaria patterns from first antenatal care visits
Detecting temporal and spatial malaria patterns from first antenatal care visits Open
Pregnant women attending first antenatal care (ANC) visits represent a promising malaria surveillance target in Sub-Saharan Africa. We assessed the spatio-temporal relationship between malaria trends at ANC ( n = 6471) and in children in t…
View article: Prostration and the prognosis of death in African children with severe malaria
Prostration and the prognosis of death in African children with severe malaria Open
Prostration is an important clinical criterion to determine severe pediatric malaria with possible fatal outcomes.
View article: Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique
Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique Open
View article: Acceptability and perceived barriers to reactive focal mass drug administration in the context of a malaria elimination program in Magude district, Southern Mozambique: A qualitative study
Acceptability and perceived barriers to reactive focal mass drug administration in the context of a malaria elimination program in Magude district, Southern Mozambique: A qualitative study Open
This study analysed acceptability and perceived barriers to reactive focal mass drug administration (rfMDA) among community members exposed to community engagement campaigns and malaria elimination interventions in Magude district, followi…