Philippos Apolinário Costa
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View article: Kaposi sarcoma incidence and mortality trends and disparities in the United States
Kaposi sarcoma incidence and mortality trends and disparities in the United States Open
Background Kaposi sarcoma (KS) is an angioproliferative tumor caused by human herpesvirus 8 and is an AIDS-defining illness. Combination antiretroviral therapy (ART) was introduced in the United States in 1996, after which U.S. KS incidenc…
View article: 907 Midkine suppresses interferon-driven antigen presentation and dendritic-cell activation in neuroendocrine tumors
907 Midkine suppresses interferon-driven antigen presentation and dendritic-cell activation in neuroendocrine tumors Open
View article: Decoding the Epigenome: Comparative Analysis of Uterine Leiomyosarcoma and Leiomyoma
Decoding the Epigenome: Comparative Analysis of Uterine Leiomyosarcoma and Leiomyoma Open
Uterine leiomyomas (ULM) and uterine leiomyosarcomas (ULMS) represent smooth muscle tumors with similar initial presentations but drastically different outcomes. This literature review analyzes the similarities and differences in their epi…
View article: Kaposi Sarcoma Incidence and Mortality Rates and Trends in the United States
Kaposi Sarcoma Incidence and Mortality Rates and Trends in the United States Open
Background Kaposi sarcoma (KS) is an angioproliferative tumor caused by human herpesvirus 8. Since antiretroviral therapy (ART) became widely available in the mid-1990s, KS incidence and mortality have fallen sharply—but persistent racial …
View article: REAÇÕES ADVERSAS PÓS-VACINAÇÃO CONTRA COVID-19: UMA REVISÃO DE COMPLICAÇÕES RARAS
REAÇÕES ADVERSAS PÓS-VACINAÇÃO CONTRA COVID-19: UMA REVISÃO DE COMPLICAÇÕES RARAS Open
View article: POLIFARMÁCIA EM IDOSOS: IMPACTOS CLÍNICOS E ESTRATÉGIAS PARA OUSO RACIONAL DE MEDICAMENTOS
POLIFARMÁCIA EM IDOSOS: IMPACTOS CLÍNICOS E ESTRATÉGIAS PARA OUSO RACIONAL DE MEDICAMENTOS Open
View article: DNA Damage Repair Pathway Alterations and Immune Landscape Differences in Pediatric/Adolescent, Young Adult (AYA) and Adult Sarcomas
DNA Damage Repair Pathway Alterations and Immune Landscape Differences in Pediatric/Adolescent, Young Adult (AYA) and Adult Sarcomas Open
Background: DNA damage response (DDR) pathway alterations contribute to genomic instability and malignant progression in several cancers. Methods: We retrospectively reviewed molecular profiles from 5309 sarcoma patient samples, including …
View article: Educação patrimonial como expressão de práticas pedagógicas territoriais subalternas
Educação patrimonial como expressão de práticas pedagógicas territoriais subalternas Open
O presente trabalho é resultado de um processo de investigação teórica que orientou a realização de um projeto de pesquisa bibliográfica sobre a relação que envolve a legitimação dos modelos de ciência e educação patrimonial dominantes e a…
View article: Twenty‐five years without progress: The enduring challenge of soft tissue sarcomas
Twenty‐five years without progress: The enduring challenge of soft tissue sarcomas Open
Over the past decade, remarkable improvements have been seen in oncology. The survival rate for breast cancer has more than doubled since 1975. Even diseases previously known for having poor prognoses, such as lung cancer, saw an improveme…
View article: Increased ager expression in inflammatory breast cancer: a comparative study with non-ibc patients
Increased ager expression in inflammatory breast cancer: a comparative study with non-ibc patients Open
View article: Educação patrimonial em Ananindeua-PA
Educação patrimonial em Ananindeua-PA Open
View article: EDUCAÇÃO PATRIMONIAL COMO EXPRESSÃO DE PRÁTICAS PEDAGÓGICAS TERRITORIAIS SUBALTERNAS
EDUCAÇÃO PATRIMONIAL COMO EXPRESSÃO DE PRÁTICAS PEDAGÓGICAS TERRITORIAIS SUBALTERNAS Open
View article: Enhancing rare cancer care in developing countries through patient advocacy: insights from the Desmoid Tumor Brazilian Association
Enhancing rare cancer care in developing countries through patient advocacy: insights from the Desmoid Tumor Brazilian Association Open
Introduction: Desmoid tumors are soft-tissue neoplasms that can have profound impacts on the lives of people living with such diseases. As they are rare tumors, patients often have difficulty finding teams specialized in sarcomas and suppo…
View article: Neoadjuvant Intra-arterial Cytoreductive Chemotherapy Improves Outcomes in Lacrimal Gland Adenoid Cystic Carcinoma
Neoadjuvant Intra-arterial Cytoreductive Chemotherapy Improves Outcomes in Lacrimal Gland Adenoid Cystic Carcinoma Open
Background Lacrimal gland adenoid cystic carcinoma (LGACC) has historically been associated with a poor prognosis even with localized disease, with a survival of 56% at 5 years. In 1988, we treated the first patient with neoadjuvant intra-…
View article: Real-Word Experience of Pazopanib and Sorafenib in Patients with Desmoid Tumors: A Cansarcc Multi-Center Study
Real-Word Experience of Pazopanib and Sorafenib in Patients with Desmoid Tumors: A Cansarcc Multi-Center Study Open
View article: Cardiac Tumors: Review
Cardiac Tumors: Review Open
Cardiac tumors are rare and encompass a variety of presentations. Clinica symptoms are usually nonspecific, but they can present as obstructive, embolic, or constitutional symptoms. Treatment options and prognosis vary highly depending on …
View article: MRI T2 mapping assessment of T2 relaxation time in desmoid tumors as a quantitative imaging biomarker of tumor response: preliminary results
MRI T2 mapping assessment of T2 relaxation time in desmoid tumors as a quantitative imaging biomarker of tumor response: preliminary results Open
Objectives Because size-based imaging criteria poorly capture biologic response in desmoid-type fibromatosis (DF), changes in MRI T2 signal intensity are frequently used as a response surrogate, but remain qualitative. We hypothesized that…
View article: Time to Cancer Treatment and Chemotherapy Relative Dose Intensity for Patients With Breast Cancer Living With HIV
Time to Cancer Treatment and Chemotherapy Relative Dose Intensity for Patients With Breast Cancer Living With HIV Open
Importance Patients with breast cancer and comorbid HIV experience higher mortality than other patients with breast cancer. Objective To compare time to cancer treatment initiation and relative dose intensity (RDI) of neoadjuvant and adjuv…
View article: Unresectable stage III non-small cell lung cancer: Insights from a Portuguese expert panel
Unresectable stage III non-small cell lung cancer: Insights from a Portuguese expert panel Open
A timely diagnosis and a proper staging contribute to the best management of each patient, optimizing treatment tolerance and effectiveness. The expert panel considered chemoradiotherapy as the preferable approach when surgery is not possi…
View article: Primary jejunal gastrointestinal stromal tumor in a patient with phakomatosis: a case report of an uncommon source of massive gastrointestinal hemorrhage
Primary jejunal gastrointestinal stromal tumor in a patient with phakomatosis: a case report of an uncommon source of massive gastrointestinal hemorrhage Open
Background: Small bowel bleeding remains a relatively uncommon event. While gastrointestinal stromal tumors (GIST) may cause a slow gastrointestinal bleeding in up to one-third of the cases, acute massive gastrointestinal bleeding related …
View article: Genomic Landscape of Angiosarcoma: A Targeted and Immunotherapy Biomarker Analysis
Genomic Landscape of Angiosarcoma: A Targeted and Immunotherapy Biomarker Analysis Open
We performed a retrospective analysis of angiosarcoma (AS) genomic biomarkers and their associations with the site of origin in a cohort of 143 cases. Primary sites were head and neck (31%), breast (22%), extremity (11%), viscera (20%), sk…
View article: Immunotherapy Strategies for Gastrointestinal Stromal Tumor
Immunotherapy Strategies for Gastrointestinal Stromal Tumor Open
Gastrointestinal stromal tumors (GIST) are the most common mesenchymal soft tissue sarcoma of the gastrointestinal tract. The management of locally advanced or metastatic unresectable GIST involves detecting KIT, PDGFR, or other molecular …
View article: Genomic Landscape of Angiosarcoma: A Targeted and Immunotherapy Biomarker Analysis
Genomic Landscape of Angiosarcoma: A Targeted and Immunotherapy Biomarker Analysis Open
We performed a comprehensive analysis of angiosarcoma (AS) genomic biomarkers and their associations with the site of origin. We aimed to describe the genomic landscape of AS in a cohort of 143 cases of AS profiled by Caris Life Sciences. …
View article: Anti-Ma paraneoplastic opsoclonus–myoclonus syndrome
Anti-Ma paraneoplastic opsoclonus–myoclonus syndrome Open
A 73-year-old woman with hypertension, type 2 diabetes and a 25 pack-year smoking history presented to the hospital with a 2-month history of dizziness, diplopia, memory loss, ataxia, insomnia and tremors. Due to the worsening of her sympt…
View article: Dose escalation of ripretinib can lead to response in advanced gastrointestinal stromal tumor patients refractory to the standard dose: a report of two cases
Dose escalation of ripretinib can lead to response in advanced gastrointestinal stromal tumor patients refractory to the standard dose: a report of two cases Open
: Despite an initial response, most metastatic gastrointestinal stromal tumor (GIST) patients will ultimately be refractory to all current therapies, including imatinib, sunitinib, and regorafenib. Ripretinib at 150 mg daily was recently a…
View article: P09.02 Impact of COVID-19 in Portuguese Lung Cancer Patients’ Treatment: Portuguese Lung Cancer Study Group Survey
P09.02 Impact of COVID-19 in Portuguese Lung Cancer Patients’ Treatment: Portuguese Lung Cancer Study Group Survey Open
View article: Advanced and Metastatic Gastrointestinal Stromal Tumours: Review of Current Knowledge and Latest Advances
Advanced and Metastatic Gastrointestinal Stromal Tumours: Review of Current Knowledge and Latest Advances Open
View article: Acute generalised exanthematous pustulosis associated with shock
Acute generalised exanthematous pustulosis associated with shock Open
A 23-year-old man with a history of end-stage renal disease was admitted to the hospital due to fever and shock, which occurred during his dialysis. One week prior, he developed an erythematous rash on his chest, face and back, associated …
View article: High-grade B-cell lymphoma with MYC and BCL6 rearrangements presenting as a cervical mass
High-grade B-cell lymphoma with MYC and BCL6 rearrangements presenting as a cervical mass Open
Lymphoid malignancies represent 0. 008% of all cervical tumours. While uncommon, lymphoid malignancies of the gynaecological tract require careful diagnosis and classification to ensure appropriate treatment. We present a case of a 54-year…
View article: Transhiatal esophagectomy with gastric pull-up, pyloric exclusion and Roux-en-Y gastroenterostomy for the management of esophageal caustic injury
Transhiatal esophagectomy with gastric pull-up, pyloric exclusion and Roux-en-Y gastroenterostomy for the management of esophageal caustic injury Open