Pedro Brugarolas
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View article: First evaluation in multiple sclerosis using PET tracer [18F]3F4AP demonstrates heterogeneous binding across lesions
First evaluation in multiple sclerosis using PET tracer [18F]3F4AP demonstrates heterogeneous binding across lesions Open
NCT04699747, Start date March 25th, 2021.
View article: A mouse model of Jansen’s metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics
A mouse model of Jansen’s metaphyseal chondrodysplasia for investigating disease mechanisms and candidate therapeutics Open
Jansen’s metaphyseal chondrodysplasia (JMC) is a rare disorder caused by activating mutations in the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor (PTH1R). Patients exhibit short stature, dysmorphic bones, and severe growt…
View article: Imaging traumatic brain injuries in mice with potassium channel PET tracer [<sup>18</sup>F]3F4AP
Imaging traumatic brain injuries in mice with potassium channel PET tracer [<sup>18</sup>F]3F4AP Open
Objective Traumatic brain injury (TBI) can lead to secondary injury, including axon and myelin damage, which contributes to long-term neurological deficits. The PET tracer [ 18 F]3F4AP, a fluorinated derivative of the FDA-approved drug 4-a…
View article: Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [ <sup>18</sup> F]3F4AP
Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [ <sup>18</sup> F]3F4AP Open
Spinal cord injuries (SCIs) often lead to lifelong disability. Among the various types of injuries, incomplete and discomplete injuries, where some axons remain intact, offer potential for recovery. However, demyelination of these spared a…
View article: Imaging of pain using positron emission tomography
Imaging of pain using positron emission tomography Open
Positron emission tomography (PET) is a noninvasive molecular imaging technique that utilizes biologically active radiolabeled compounds to image biochemical processes. As such, PET can provide important pathophysiological information asso…
View article: Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine
Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine Open
4-aminopyridine (4AP) is a potassium (K + ) channel blocker used clinically to improve walking in people with multiple sclerosis (MS). 4AP binds to exposed K + channels in demyelinated axons, reducing the leakage of intracellular K + and e…
View article: Common anesthetic used in preclinical <scp>PET</scp> imaging inhibits metabolism of the <scp>PET</scp> tracer [ <scp> <sup>18</sup> F </scp> ] <scp>3F4AP</scp>
Common anesthetic used in preclinical <span>PET</span> imaging inhibits metabolism of the <span>PET</span> tracer [ <span> <sup>18</sup> F </span> ] <span>3F4AP</span> Open
Positron emission tomography (PET) imaging studies in laboratory animals are almost always performed under isoflurane anesthesia to ensure that the subject stays still during the image acquisition. Isoflurane is effective, safe, and easy t…
View article: Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP
Radiosynthesis automation, non-human primate biodistribution and dosimetry of K+ channel tracer [11C]3MeO4AP Open
Background 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [ 11 C]3MeO4AP has shown promise due…
View article: Imaging demyelinated axons after spinal cord injuries with PET tracer [<sup>18</sup>F]3F4AP
Imaging demyelinated axons after spinal cord injuries with PET tracer [<sup>18</sup>F]3F4AP Open
Spinal cord injuries (SCI) often lead to lifelong disability. Among the various types of injuries, incomplete and discomplete injuries, where some axons remain intact, offer potential for recovery. However, demyelination of these spared ax…
View article: Fluorine-18 incorporation and radiometal coordination in macropa ligands for PET imaging and targeted alpha therapy
Fluorine-18 incorporation and radiometal coordination in macropa ligands for PET imaging and targeted alpha therapy Open
The development of theranostic agents for radiopharmaceuticals based on therapeutic alpha emitters marks an important clinical need.
View article: Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [<sup>18</sup>F]3F4AP
Common anesthetic used in preclinical PET imaging inhibits metabolism of the PET tracer [<sup>18</sup>F]3F4AP Open
PET imaging studies in laboratory animals are almost always performed under isoflurane anesthesia to ensure that the subject stays still during the image acquisition. Isoflurane is effective, safe, and easy to use, and it is generally assu…
View article: Evaluation of <i>trans</i>- and <i>cis</i>-4-[<sup>18</sup>F]Fluorogabapentin for Brain PET Imaging
Evaluation of <i>trans</i>- and <i>cis</i>-4-[<sup>18</sup>F]Fluorogabapentin for Brain PET Imaging Open
Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy, and other neurological conditions. We recently described two rad…
View article: Evaluation of<i>trans</i>- and<i>cis</i>-4-[<sup>18</sup>F]fluorogabapentin for brain PET imaging
Evaluation of<i>trans</i>- and<i>cis</i>-4-[<sup>18</sup>F]fluorogabapentin for brain PET imaging Open
Gabapentin, a selective ligand for the α2δ subunit of voltage-dependent calcium channels, is an anticonvulsant medication used in the treatment of neuropathic pain, epilepsy and other neurological conditions. We recently described two radi…
View article: Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine
Chemical and biophysical characterization of novel potassium channel blocker 3-fluoro-5-methylpyridin-4-amine Open
4-aminopyridine (4AP) is a potassium (K + ) channel blocker used clinically to improve walking in people with multiple sclerosis (MS). 4AP binds to exposed K + channels in demyelinated axons, reducing the leakage of intracellular K + and e…
View article: Radiosynthesis automation, non-human primate biodistribution and dosimetry of K<sup>+</sup>channel tracer [<sup>11</sup>C]3MeO4AP
Radiosynthesis automation, non-human primate biodistribution and dosimetry of K<sup>+</sup>channel tracer [<sup>11</sup>C]3MeO4AP Open
Purpose 4-Aminopyridine (4AP) is a medication for the symptomatic treatment of multiple sclerosis. Several 4AP-based PET tracers have been developed for imaging demyelination. In preclinical studies, [ 11 C]3MeO4AP has shown promise due to…
View article: Broad‐scope Syntheses of [<sup>11</sup>C/<sup>18</sup>F]Trifluoromethylarenes from Aryl(mesityl)iodonium Salts
Broad‐scope Syntheses of [<sup>11</sup>C/<sup>18</sup>F]Trifluoromethylarenes from Aryl(mesityl)iodonium Salts Open
Efficient methods for labeling aryl trifluoromethyl groups to provide novel radiotracers for use in biomedical research with positron emission tomography (PET) are keenly sought. We report a broad‐scope method for labeling trifluoromethyla…
View article: Radiochemical Synthesis and Evaluation of 3-[<sup>11</sup>C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS
Radiochemical Synthesis and Evaluation of 3-[<sup>11</sup>C]Methyl-4-aminopyridine in Rodents and Nonhuman Primates for Imaging Potassium Channels in the CNS Open
Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In…
View article: Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP Open
Purpose [ 18 F]3F4AP is a novel PET radiotracer that targets voltage-gated potassium (K + ) channels and has shown promise for imaging demyelinated lesions in animal models of neurological diseases. This study aimed to evaluate the biodist…
View article: Metabolic Stability of the Demyelination PET Tracer [<sup>18</sup>F]3F4AP and Identification of its Metabolites
Metabolic Stability of the Demyelination PET Tracer [<sup>18</sup>F]3F4AP and Identification of its Metabolites Open
[ 18 F]3-fluoro-4-aminopyridine ([ 18 F]3F4AP) is a PET tracer for imaging demyelination based on the multiple sclerosis drug 4-aminopyridine (4AP, dalfampridine). This radiotracer was found to be stable in rodents and nonhuman primates im…
View article: Radiochemical Synthesis and Evaluation of 3-[<sup>11</sup>C]Methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS
Radiochemical Synthesis and Evaluation of 3-[<sup>11</sup>C]Methyl-4-aminopyridine in Rodents and Non-Human Primates for Imaging Potassium Channels in the CNS Open
Demyelination, the loss of the insulating sheath of neurons, causes failed or slowed neuronal conduction and contributes to the neurological symptoms in multiple sclerosis, traumatic brain and spinal cord injuries, stroke, and dementia. In…
View article: Human biodistribution and radiation dosimetry of the demyelination tracer [<sup>18</sup>F]3F4AP
Human biodistribution and radiation dosimetry of the demyelination tracer [<sup>18</sup>F]3F4AP Open
Purpose [ 18 F]3F4AP is a novel PET radiotracer that targets voltage-gated potassium (K + ) channels and has shown promise for imaging demyelinated lesions in animal models of neurological diseases. This study aimed to evaluate the biodist…
View article: Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain
Development of a PET radioligand for α2δ-1 subunit of calcium channels for imaging neuropathic pain Open
Neuropathic pain affects 7-10% of the adult population. Being able to accurately monitor biological changes underlying neuropathic pain will improve our understanding of neuropathic pain mechanisms and facilitate the development of novel t…
View article: Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[ <sup>11</sup> C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS
Radiochemical Synthesis and Evaluation in Non-Human Primates of 3-[ <sup>11</sup> C]methoxy-4-aminopyridine: A Novel PET Tracer for Imaging Potassium Channels in the CNS Open
Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, i…
View article: Radiochemical synthesis and evaluation in nonhuman primates of 3-[<sup>11</sup>C]methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS
Radiochemical synthesis and evaluation in nonhuman primates of 3-[<sup>11</sup>C]methoxy-4-aminopyridine: a novel PET tracer for imaging potassium channels in the CNS Open
Demyelination, the loss of the protecting sheath of neurons, contributes to disability in many neurological diseases. In order to fully understand its role in different diseases and to monitor treatments aiming at reversing this process, i…
View article: Evaluation of the potassium channel tracer [ <sup>18</sup> F]3F4AP in rhesus macaques
Evaluation of the potassium channel tracer [ <sup>18</sup> F]3F4AP in rhesus macaques Open
Demyelination causes slowed or failed neuronal conduction and is a driver of disability in multiple sclerosis and other neurological diseases. Currently, the gold standard for imaging demyelination is MRI, but despite its high spatial reso…