Pedro Castro
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View article: Endothelial dysfunction and hemostatic imbalance in CAR T-cell-associated toxicities: pathophysiological insights and the role of circulating biomarkers
Endothelial dysfunction and hemostatic imbalance in CAR T-cell-associated toxicities: pathophysiological insights and the role of circulating biomarkers Open
Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of relapsed or refractory hematologic malignancies. While its clinical efficacy is well established, CAR T-cell therapy is frequently associated with severe im…
View article: Clinical Outcomes and Treatment Strategies in Catastrophic High-Risk Pulmonary Embolism: A Retrospective Analysis
Clinical Outcomes and Treatment Strategies in Catastrophic High-Risk Pulmonary Embolism: A Retrospective Analysis Open
High-risk pulmonary embolism (PE) is a life-threatening condition characterized by he-modynamic instability, often leading to catastrophic outcomes such as cardiac arrest and cardiogenic shock. We conducted a retrospective analysis of pati…
View article: Retrospective Cohort Study of Intrapericardial Cisplatin for Risk Reduction of Malignant Pericardial Effusion Recurrence
Retrospective Cohort Study of Intrapericardial Cisplatin for Risk Reduction of Malignant Pericardial Effusion Recurrence Open
Malignant pericardial effusion (MPE) is a life-threatening condition in patients with cancer, with common recurrences after simple pericardiocentesis. Consequently, the intrapericardial instillation of sclerosing or cytotoxic agents has be…
View article: Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study
Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study Open
Patients with cancer and ARDS, particularly severe forms, experience high 90-day mortality, irrespective of ECMO use. These findings suggest a need for nuanced ICU goals-of-care discussions and raise concerns about the generalizability of …
View article: Neurovascular coupling assessment by transcranial doppler in acute stroke could be informative of long-term cognitive status
Neurovascular coupling assessment by transcranial doppler in acute stroke could be informative of long-term cognitive status Open
To assess whether Neurovascular Coupling (NVC) status in acute ischemic stroke predicts long-term cognitive impairment, this prospective study included consecutive ischemic stroke patients, without prior cognitive deficits, recruited betwe…
View article: Advocating for the recognition of underlying immunosuppression in critical illness
Advocating for the recognition of underlying immunosuppression in critical illness Open
Not receiving any funding.
View article: Protocolo de vigilancia de la salud mental de los residentes durante la formación sanitaria especializada
Protocolo de vigilancia de la salud mental de los residentes durante la formación sanitaria especializada Open
The prevalence of burnout among residents is high. Residency period involves several work-related stressors linked to medical training, in addition to exposure to psychosocial factors inherent to complex organizations such as teaching hosp…
View article: 20524. RIESGO DE DETERIORO COGNITIVO Y ENFERMEDAD DE ALZHEIMER EN PACIENTES CON MIASTENIA GRAVIS
20524. RIESGO DE DETERIORO COGNITIVO Y ENFERMEDAD DE ALZHEIMER EN PACIENTES CON MIASTENIA GRAVIS Open
View article: 20731. MODELOS DE REGRESIÓN PREDICTIVA PARA EL DETERIORO COGNITIVO LEVE Y LA ENFERMEDAD DE ALZHEIMER UTILIZANDO REGISTROS ELECTRÓNICOS DE SALUD EN EL MUNDO REAL
20731. MODELOS DE REGRESIÓN PREDICTIVA PARA EL DETERIORO COGNITIVO LEVE Y LA ENFERMEDAD DE ALZHEIMER UTILIZANDO REGISTROS ELECTRÓNICOS DE SALUD EN EL MUNDO REAL Open
View article: Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study
Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study Open
View article: Septic shock in the immunocompromised cancer patient: a narrative review
Septic shock in the immunocompromised cancer patient: a narrative review Open
Immunosuppressed patients, particularly those with cancer, represent a momentous and increasing portion of the population, especially as cancer incidence rises with population growth and aging. These patients are at a heightened risk of de…
View article: Forest disturbance regimes and trends in continental Spain (1985–2023) using dense landsat time series
Forest disturbance regimes and trends in continental Spain (1985–2023) using dense landsat time series Open
Forest disturbance regimes across biomes are being altered by interactive effects of global change. Establishing baselines for assessing change requires detailed quantitative data on past disturbance events, but such data are scarce and di…
View article: Implementation of the TALK© clinical self-debriefing tool in operating theatres: a single-centre interventional study
Implementation of the TALK© clinical self-debriefing tool in operating theatres: a single-centre interventional study Open
A simple intervention introducing TALK© for voluntary debriefing in theatres prompted significant changes in team behaviour and sustained growth regarding consideration and performance of debriefing, especially in the first 6 months.
View article: Is spontaneous pneumomediastinum really spontaneous?
Is spontaneous pneumomediastinum really spontaneous? Open
Nearly 500 intentional MCIs have occurred in Europe in this XXI century. Most involved explosives or firearms. However, motor vehicles are the most potentially harmful weapons, and their use is increasing. These data may help to improve MC…
View article: Clinical characteristics and outcomes of immunocompromised critically ill patients with cytomegalovirus end-organ disease: a multicenter retrospective cohort study
Clinical characteristics and outcomes of immunocompromised critically ill patients with cytomegalovirus end-organ disease: a multicenter retrospective cohort study Open
Background Cytomegalovirus (CMV) infection in patients with cellular immune deficiencies is associated with significant morbidity and mortality. However, data on CMV end-organ disease (CMV-EOD) in critically ill, immunocompromised patients…
View article: Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions?
Not all severe malaria cases are severe: Is it time to redefine severity criteria for malaria in non-endemic regions? Open
Severity criteria definitions would benefit from a review when assessing patients with malaria in non-endemic areas. Within the spectrum of SM, patients reclassified as LSM have a low risk of developing a life-threatening condition and pre…
View article: Platelet transfusions in adult <scp>ICU</scp> patients with thrombocytopenia: A sub‐study of the <scp>PLOT</scp>‐<scp>ICU</scp> inception cohort study
Platelet transfusions in adult <span>ICU</span> patients with thrombocytopenia: A sub‐study of the <span>PLOT</span>‐<span>ICU</span> inception cohort study Open
Background Platelet transfusions are frequently used in the intensive care unit (ICU), but current practices including used product types, volumes, doses and effects are unknown. Study design and methods Sub‐study of the inception cohort s…
View article: Characterisation and Outcomes of Patients with Solid Organ Malignancies Admitted to the Intensive Care Unit: Mortality and Impact on Functional Status and Oncological Treatment
Characterisation and Outcomes of Patients with Solid Organ Malignancies Admitted to the Intensive Care Unit: Mortality and Impact on Functional Status and Oncological Treatment Open
Background: Despite the increasing number of ICU admissions among patients with solid tumours, there is a lack of tools with which to identify patients who may benefit from critical support. We aim to characterize the clinical profile and …
View article: Factors Associated with the Number of Injured and Fatalities in Motor Vehicle Intentional Mass-Casualty Incidents: A Timely Aid for Scaling the Emergency Response
Factors Associated with the Number of Injured and Fatalities in Motor Vehicle Intentional Mass-Casualty Incidents: A Timely Aid for Scaling the Emergency Response Open
Introduction: Intentional mass-casualty incidents (IMCIs) involving motor vehicles (MVs) as weapons represent a growing trend in Western countries. This method has resulted in the highest casualty rates per incident within the field of IMC…
View article: Disturbance Regimes and Trends in Continental Spain (1985- 2023) Using Dense Landsat Time Series
Disturbance Regimes and Trends in Continental Spain (1985- 2023) Using Dense Landsat Time Series Open
View article: Platelet transfusions in adult thrombocytopenic <scp>ICU</scp> patients: Protocol for a sub‐study of the <scp>PLOT‐ICU</scp> cohort
Platelet transfusions in adult thrombocytopenic <span>ICU</span> patients: Protocol for a sub‐study of the <span>PLOT‐ICU</span> cohort Open
Introduction Platelet transfusions are frequently used in intensive care unit (ICU) patients, but contemporary epidemiological data are sparse. We aim to present contemporary international data on the use of platelet transfusions in adult …
View article: Publisher Correction: Early corticosteroids are associated with lower mortality in critically ill patients with COVID‑19: a cohort study
Publisher Correction: Early corticosteroids are associated with lower mortality in critically ill patients with COVID‑19: a cohort study Open
View article: Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)
Correction: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) Open
View article: Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation
Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation Open
View article: Early detection of deterioration in COVID-19 patients by continuous ward respiratory rate monitoring: a pilot prospective cohort study
Early detection of deterioration in COVID-19 patients by continuous ward respiratory rate monitoring: a pilot prospective cohort study Open
Background Tachypnea is among the earliest signs of pulmonary decompensation. Contactless continuous respiratory rate monitoring might be useful in isolated COVID-19 patients admitted in wards. We therefore aimed to determine whether conti…
View article: BREVE HISTORIA DE LA CARTOGRAFÍA GEOLÓGICA EN EL DEPARTAMENTO DE ANTIOQUIA, COLOMBIA
BREVE HISTORIA DE LA CARTOGRAFÍA GEOLÓGICA EN EL DEPARTAMENTO DE ANTIOQUIA, COLOMBIA Open
A pesar de la tradición minera del departamento de Antioquia, su cartografía geológica sistemática sólo se inició por iniciativa regional a principios del siglo XX y culminó a fines del mismo. Se analizan las labores realizadas por la Comi…
View article: Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU)
Thrombocytopenia and platelet transfusions in ICU patients: an international inception cohort study (PLOT-ICU) Open
View article: OC 10.5 Endotheliopathy, Innate-Immune Activation and Hemostatic Imbalance Underlying CAR -T Cell Toxicities: Tools for Early and Differential Diagnosis
OC 10.5 Endotheliopathy, Innate-Immune Activation and Hemostatic Imbalance Underlying CAR -T Cell Toxicities: Tools for Early and Differential Diagnosis Open
View article: Post-hospital recovery trajectories of family members of critically ill COVID-19 survivors: an international qualitative investigation
Post-hospital recovery trajectories of family members of critically ill COVID-19 survivors: an international qualitative investigation Open
View article: Exploring the Spectrum of <scp><i>RHOBTB2</i></scp> Variants Associated with Developmental Encephalopathy 64: A Case Series and Literature Review
Exploring the Spectrum of <span><i>RHOBTB2</i></span> Variants Associated with Developmental Encephalopathy 64: A Case Series and Literature Review Open
Background Rho‐related BTB domain‐containing protein 2 ( RHOBTB2 ) is a protein that interacts with cullin‐3, a crucial E3 ubiquitin ligase for mitotic cell division. RHOBTB2 has been linked to early infantile epileptic encephalopathy, aut…