Pedro Cravo
YOU?
Author Swipe
View article: Evaluation of the Activity of 4-Quinolones against Multi-Life Stages of <i>Plasmodium</i> spp.
Evaluation of the Activity of 4-Quinolones against Multi-Life Stages of <i>Plasmodium</i> spp. Open
Malaria is a critical global health problem, with high mortality and morbidity rates, which ultimately hinder socioeconomic development in endemic areas. The evolution of drug resistance in malaria parasites, particularly in the case of
View article: A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants Open
Artemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by widespread partial artemisinin resistance in Southeast Asia and its…
View article: Chalcone Derivatives: Promising Starting Points for Drug Design
Chalcone Derivatives: Promising Starting Points for Drug Design Open
Medicinal chemists continue to be fascinated by chalcone derivatives because of their simple chemistry, ease of hydrogen atom manipulation, straightforward synthesis, and a variety of promising biological activities. However, chalcones hav…
View article: QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities
QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities Open
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved …
View article: Modern approaches to accelerate discovery of new antischistosomal drugs
Modern approaches to accelerate discovery of new antischistosomal drugs Open
INTRODUCTION: The almost exclusive use of only praziquantel for the treatment of schistosomiasis has raised concerns about the possible emergence of drug-resistant schistosomes. Consequently, there is an urgent need for new antischistosoma…
View article: Innovative Multistage ML-QSAR Models for Malaria: From Data to Discovery
Innovative Multistage ML-QSAR Models for Malaria: From Data to Discovery Open
Malaria presents a significant challenge to global public health, with around 247 million cases estimated to occur annually worldwide. The growing resistance of Plasmodium parasites to existing therapies underscores the urgent need …
View article: Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination
Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination Open
Introduction The global evolution of resistance to Artemisinin-based Combination Therapies (ACTs) by malaria parasites, will severely undermine our ability to control this devastating disease. Methods Here, we have used whole genome sequen…
View article: Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin
Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin Open
Introduction Malaria parasites increasingly develop resistance to all drugs available in the market, hampering the goal of reducing malaria burden. Methods Herein, we evaluated the impact of a single-nucleotide variant, E738K, present in t…
View article: Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditional Medicine
Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditional Medicine Open
Medicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal p…
View article: Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plants
Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plants Open
The use of medicinal plants in a variety of health conditions remains essential for the discovery of new treatments. The present study aimed to investigate the bioactive properties of three native plants from Cabo Verde Islands, namely Art…
View article: Studies on the in vitro antiplasmodial activity of endemic and native plants from Cabo Verde
Studies on the in vitro antiplasmodial activity of endemic and native plants from Cabo Verde Open
Background Traditional medicinal plants and other remedies are one of the many potential sources of new antimalarial drugs, there being an increasing interest in studying their potential for the treatment of malaria and other illnesses. Th…
View article: On the contribution of the rodent model Plasmodium chabaudi for understanding the genetics of drug resistance in malaria
On the contribution of the rodent model Plasmodium chabaudi for understanding the genetics of drug resistance in malaria Open
View article: On the Contribution of the Rodent Model Plasmodium Chabaudi for Understanding the Genetics of Drug Resistance in Malaria
On the Contribution of the Rodent Model Plasmodium Chabaudi for Understanding the Genetics of Drug Resistance in Malaria Open
View article: Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity
Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity Open
Antimalarial drugs with novel modes of action and wide therapeutic potential are needed to pave the way for malaria eradication. Violacein is a natural compound known for its biological activity against cancer cells and several pathogens, …
View article: Atlantic Forest Malaria: A Review of More than 20 Years of Epidemiological Investigation
Atlantic Forest Malaria: A Review of More than 20 Years of Epidemiological Investigation Open
In the south and southeast regions of Brazil, cases of malaria occur outside the endemic Amazon region near the Atlantic Forest in some coastal states, where Plasmodium vivax is the recognized parasite. Characteristics of cases and vectors…
View article: Correction for Ferreira et al., “Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax”
Correction for Ferreira et al., “Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax” Open
Volume 64, no. 9, e02041-19, 2020, https://doi.org/10.1128/AAC.02041-19. Page 1: This article was published on 20 August 2020 with a standard copyright line (“© 2020 American Society for Microbiology. All Rights Reserved.”). The authors el…
View article: Detection of<i>Plasmodium vivax</i>in a liver sample of a howler-monkey: one evidence more in favour of the identity between<i>Plasmodium simium</i>and<i>P. vivax</i>
Detection of<i>Plasmodium vivax</i>in a liver sample of a howler-monkey: one evidence more in favour of the identity between<i>Plasmodium simium</i>and<i>P. vivax</i> Open
Introduction The residual malaria of Atlantic Forest systems in Brazil occurs as an endemic disease with low frequency of cases. The chronological and spatial distance among the cases indicate an absence of fitness to the classical malaria…
View article: Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax
Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax Open
Widespread resistance against antimalarial drugs thwarts current efforts for controlling the disease and urges the discovery of new effective treatments. Drug repositioning is increasingly becoming an attractive strategy since it can reduc…
View article: Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs
Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs Open
The current literature highlights the contribution of efflux pumps in drug resistance in M. tuberculosis and that efflux inhibitors may help to ensure the effectiveness of anti-TB drugs. However, despite the usefulness of efflux inh…
View article: Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs
Efflux pump inhibitors as a promising adjunct therapy against drug resistant tuberculosis: a new strategy to revisit mycobacterial targets and repurpose old drugs Open
Introduction: In 2018, an estimated 377,000 people developed multidrug-resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has been accepted that efflux pumps play an important role in the evo…
View article: Apresentação
Apresentação Open
View article: Apresentação
Apresentação Open
View article: Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene Open
Although the sample size is relatively small, these results suggest that P. falciparum artemisinin-resistant mutants do not exist in Brazil, thereby supporting the continuation of current treatment programs based on artemisinin-based combi…
View article: Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene
Plasmodium falciparum malarial parasites from Brazil lack artemisinin resistance-associated mutations in the kelch13 gene Open
INTRODUCTION Mutations in the propeller domain of the Plasmodium falciparum kelch13 (k13) gene are associated with artemisinin resistance. METHODS: We developed a PCR protocol to sequence the pfk13 gene and determined its sequence in a bat…
View article: Apresentação
Apresentação Open
View article: Apresentação
Apresentação Open
View article: Is there still room to explore cyclodextrin glycosyltransferase-producers in Brazilian biodiversity?
Is there still room to explore cyclodextrin glycosyltransferase-producers in Brazilian biodiversity? Open
In the present work, different Brazilian biomes aiming to identify and select cyclodextrin glycosyltransferase-producer bacteria are explored. This enzyme is responsible for converting starch to cyclodextrin, which are interesting molecule…
View article: QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities
QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities Open
Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have e…
View article: Apresentação
Apresentação Open
View article: In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate
In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate Open
The MAEBL antigen is promising candidate towards the development of a malaria vaccine.