Pedro Majano
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View article: Biomarker and clinical data–based predictor tool (MAUXI) for ultrafiltration failure and cardiovascular outcome in peritoneal dialysis patients: a retrospective and longitudinal study
Biomarker and clinical data–based predictor tool (MAUXI) for ultrafiltration failure and cardiovascular outcome in peritoneal dialysis patients: a retrospective and longitudinal study Open
Objectives To develop a machine learning-based software as a medical device to predict the endurance and outcomes of peritoneal dialysis (PD) patients in real time using effluent-measured biomarkers of the mesothelial-to-mesenchymal transi…
View article: Proton pump inhibitor effect on esophageal protein signature of eosinophilic esophagitis, prediction, and evaluation of treatment response
Proton pump inhibitor effect on esophageal protein signature of eosinophilic esophagitis, prediction, and evaluation of treatment response Open
Background Recently, we have identified a dysregulated protein signature in the esophageal epithelium of eosinophilic esophagitis (EoE) patients including proteins associated with inflammation and epithelial barrier function; however, the …
View article: Author response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Author response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Appendix 1 Data availability References Article and author information Metrics Abstract Epithelial intercel…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, …
View article: Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment
Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment Open
Objectives The aim of the study was to characterize the circulating immunome of patients with EoE before and after proton pump inhibitor (PPI) treatment in order to identify potential non-invasive biomarkers of treatment response. Methods …
View article: Impact of STAT6 Variants on the Response to Proton Pump Inhibitors and Comorbidities in Patients with Eosinophilic Esophagitis
Impact of STAT6 Variants on the Response to Proton Pump Inhibitors and Comorbidities in Patients with Eosinophilic Esophagitis Open
Proton pump inhibitors (PPIs) are the first-line drug for eosinophilic esophagitis (EoE), although it is estimated that there is a lack of histological remission in 50% of patients. This research aimed to identify pharmacogenetic biomarker…
View article: Author Response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Author Response: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: A New Method to Evaluate Lower Esophageal Distension Capacity in Eosinophilic Esophagitis by Using Functional Lumen Imaging Probe (EndoFLIP™)
A New Method to Evaluate Lower Esophageal Distension Capacity in Eosinophilic Esophagitis by Using Functional Lumen Imaging Probe (EndoFLIP™) Open
Endoluminal functional lumen impedance planimetry (EndoFLIPTM) has become the gold standard to evaluate esophageal distensibility, although the study itself and its analysis present challenges. We propose here a new method to assess lower …
View article: Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment
Circulating immunome fingerprint in eosinophilic esophagitis is associated with clinical response to proton pump inhibitor treatment Open
Objectives The aim of the study was to characterize the circulating immunome of patients with EoE before and after proton pump inhibitor (PPI) treatment in order to identify potential non-invasive biomarkers of treatment response. Methods …
View article: Proton pump Inhibitor effect on esophageal protein signature of eosinophilic esophagitis, prediction and evaluation of treatment response
Proton pump Inhibitor effect on esophageal protein signature of eosinophilic esophagitis, prediction and evaluation of treatment response Open
Background Recently, we have identified a dysregulated protein signature in the esophageal epithelium of eosinophilic esophagitis (EoE) patients; however, the effect of proton pump inhibitor (PPI) treatment on this signature is unknown. He…
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial intercellular adhesion molecule (ICAM)-1 is apically polarized, interacts with, and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, …
View article: A New Method to Evaluate Lower Esophageal Distension Capacity in Eosinophilic Esophagitis by using functional lumen imaging probe (Endoflip™)
A New Method to Evaluate Lower Esophageal Distension Capacity in Eosinophilic Esophagitis by using functional lumen imaging probe (Endoflip™) Open
Background Endoluminal functional lumen impedance planimetry (Endoflip TM ) has become the gold standard to evaluate esophageal distensibility, although the study itself and its analysis present challenges. We propose here a new method to …
View article: ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin Open
Epithelial Intercellular Adhesion Molecule (ICAM)-1 is apically polarized, interacts with and guides leukocytes across epithelial barriers. Polarized hepatic epithelia organize their apical membrane domain into bile canaliculi and ducts, w…
View article: E-141 Development of the circle of willis score (COWS) to help guide decision making during acute tandem occlusion treatment
E-141 Development of the circle of willis score (COWS) to help guide decision making during acute tandem occlusion treatment Open
Introduction/Purpose Acute tandem occlusions (TOs) are challenging to treat, and controversies exist regarding both the sequence of steps as well as how to handle the proximal occlusion in the acute setting. Although there is mounting evid…
View article: Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology
Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology Open
Background Eosinophilic esophagitis (EoE) is a chronic non‐IgE‐mediated allergic disease of the esophagus. An unbiased proteomics approach was performed to investigate pathophysiological changes in esophageal epithelium. Additionally, an R…
View article: Esophageal biomechanics assessed by impedance planimetry (EndoFLIP TM) in healthy subjects and in patients with eosinophilic esophagitis. Normality values
Esophageal biomechanics assessed by impedance planimetry (EndoFLIP TM) in healthy subjects and in patients with eosinophilic esophagitis. Normality values Open
esophago-gastric junction distensibility index, distensibility plateau and diameter values were higher in controls than in patients, although six weeks of treatment seems a short period to observe significant changes in esophageal biomecha…
View article: Cardiac Radiographic Measurements in Ferrets Using the OsiriX MD Programme
Cardiac Radiographic Measurements in Ferrets Using the OsiriX MD Programme Open
Objectives: To adapt the vertebral heart scale (VHS) for use in ferrets and identify new scales and tools that allow to establish the normal heart size by means of radiography more quickly and effectively. Methods: Forty healthy pet ferret…
View article: Characterization of Patients with Inguinal Hernia Ambulatory Surgical Treatment
Characterization of Patients with Inguinal Hernia Ambulatory Surgical Treatment Open
Introduction: the surgical treatment of inguinal hernia has increased in the last decade and its prevalence is not known. Objective: Characterization of patients with inguinal hernia ambulatory surgical treatment. Methods: an observational…
View article: Modified Desarda Repair and Hernioplastia Lichtenstein Repair for Inguinal Hernia.
Modified Desarda Repair and Hernioplastia Lichtenstein Repair for Inguinal Hernia. Open
Introduction: The objective of this study is to compare the outcomes of Modified Desarda repair no mesh and Lichtenstein repair for inguinal hernia. Methods: This is a prospective randomized controlled trial study of 1342 patients having 1…
View article: Molecular analysis of pancreatic cystic neoplasm in routine clinical practice
Molecular analysis of pancreatic cystic neoplasm in routine clinical practice Open
Molecular analysis can improve the classification of pancreatic cysts as mucinous or non-mucinous. Mutations were not able to detect malignant lesions.
View article: Sofosbuvir improves HCV‐induced insulin resistance by blocking IRS1 degradation
Sofosbuvir improves HCV‐induced insulin resistance by blocking IRS1 degradation Open
In the present study, we have demonstrated that sofosbuvir (SOF) treatment improves systemic insulin resistance in hepatitis C virus (HCV)-patients, and, for the first time, revealed which molecular mechanisms are involved in SOF effects o…
View article: Poor Sensitivity of Fecal Gluten Immunogenic Peptides and Serum Antibodies to Detect Duodenal Mucosal Damage in Celiac Disease Monitoring
Poor Sensitivity of Fecal Gluten Immunogenic Peptides and Serum Antibodies to Detect Duodenal Mucosal Damage in Celiac Disease Monitoring Open
A lifelong gluten-free diet (GFD) is the only current treatment for celiac disease (CD), but strict compliance is complicated. Duodenal biopsies are the “gold standard” method for diagnosing CD, but they are not generally recommended for d…
View article: The Lichtenstein Plug Technique.the Safe Repair
The Lichtenstein Plug Technique.the Safe Repair Open
Summary Various techniques have been developed for the repair of femoral hernia. The technique with the Lichtenstein Plug since 1989 has allowed to obtain a lower rate of complications and recurrences, as well as an early recovery of the p…
View article: Naturally Occurring and Engineered Alphaviruses Sensitive to Double-Stranded-RNA-Activated Protein Kinase Show Restricted Translation in Mammalian Cells, Increased Sensitivity to Interferon, and Marked Oncotropism
Naturally Occurring and Engineered Alphaviruses Sensitive to Double-Stranded-RNA-Activated Protein Kinase Show Restricted Translation in Mammalian Cells, Increased Sensitivity to Interferon, and Marked Oncotropism Open
Interferons (IFNs) induce the expression of a number of antiviral genes that protect the cells of vertebrates against viruses and other microbes. The susceptibility of cells to viruses greatly depends on the level and activity of these ant…
View article: Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition
Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition Open
Epithelial-to-mesenchymal transition (EMT) is a self-regulated physiological process required for tissue repair that, in non-controled conditions may lead to fibrosis, angiogenesis, loss of normal organ function or cancer. Although several…
View article: DETERMINACIÓN DE GLUCOSA INTRAQUÍSTICA EN EL ESTUDIO DE NEOPLASIAS QUÍSTICAS PANCREÁTICAS
DETERMINACIÓN DE GLUCOSA INTRAQUÍSTICA EN EL ESTUDIO DE NEOPLASIAS QUÍSTICAS PANCREÁTICAS Open
View article: UTILIDAD DE LA TINCIÓN DE MUCINAS PARA EL DIAGNÓSTICO DE NEOPLASIAS QUÍSTICAS MUCINOSAS
UTILIDAD DE LA TINCIÓN DE MUCINAS PARA EL DIAGNÓSTICO DE NEOPLASIAS QUÍSTICAS MUCINOSAS Open
View article: ESTUDIO PROSPECTIVO DE LOS CRITERIOS ENDOSONOGRÁFICOS DE SOSPECHA DE MALIGNIDAD EN PACIENTES CON QUISTES PANCREÁTICOS
ESTUDIO PROSPECTIVO DE LOS CRITERIOS ENDOSONOGRÁFICOS DE SOSPECHA DE MALIGNIDAD EN PACIENTES CON QUISTES PANCREÁTICOS Open
View article: Corrigendum to “T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage”
Corrigendum to “T Helper 17/Regulatory T Cell Balance and Experimental Models of Peritoneal Dialysis-Induced Damage” Open
[This corrects the article DOI: 10.1155/2015/416480.].