Pedro L. Sánchez
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View article: Spectral Dual-Layer CT Identifies Key Diagnostic Features in Stress Cardiomyopathy
Spectral Dual-Layer CT Identifies Key Diagnostic Features in Stress Cardiomyopathy Open
View article: The Role of the BMPR2 Pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease
The Role of the BMPR2 Pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease Open
View article: Left atrial appendage closure in patients with prior intracranial bleeding, safety, efficacy, and timing
Left atrial appendage closure in patients with prior intracranial bleeding, safety, efficacy, and timing Open
Left atrial appendage occlusion is an effective and safe treatment alternative to reduce the risk of ischemic stroke in selected patients with atrial fibrillation and prior intracranial hemorrhage. In this study, we did not find difference…
View article: Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial
Beta-blockers after myocardial infarction: effects according to sex in the REBOOT trial Open
Background and Aims Recent trials have challenged the guideline recommendation of beta-blockers for post-myocardial infarction (MI) patients without reduced left ventricular ejection fraction (LVEF). Whether these recent findings apply equ…
View article: NTproBNP as an independent predictor of all-cause mortality in elderly cancer patients
NTproBNP as an independent predictor of all-cause mortality in elderly cancer patients Open
Introduction Cardiac biomarkers are well-established predictors of cardiotoxicity. However, their role in predicting mortality among elderly cancer patients receiving antineoplastic therapy remains unclear. This study aimed to analyze all-…
View article: Semantic and Visual Pathways to Artificial intelligence Literacy. Challenges and Lessons Learned in the Medical Domain
Semantic and Visual Pathways to Artificial intelligence Literacy. Challenges and Lessons Learned in the Medical Domain Open
Artificial intelligence (AI) enhances medical research through greater accuracy and large-scale data handling. However, many healthcare professionals face methodological and reproducibility challenges due to limited AI training. Visual pro…
View article: Patient reported experience measures in TAVI procedures: VALVEX study
Patient reported experience measures in TAVI procedures: VALVEX study Open
The evaluation of patient experience allows us to improve the information given to the patient during their TAVI process and it can also allow patients to be more relax, aware and prepared for the procedure. Continuous follow up enables mo…
View article: Multivalent COBRA Hemagglutinin and Neuraminidase Influenza Vaccines Adjuvanted with TLR9 Agonist CpG 1018
Multivalent COBRA Hemagglutinin and Neuraminidase Influenza Vaccines Adjuvanted with TLR9 Agonist CpG 1018 Open
Background/Objectives: There is a need for effective seasonal influenza virus vaccines that provide broad and long-lasting protection against influenza virus infections. Methods: In this study, next-generation influenza hemagglutinin (HA) …
View article: Empowering Supply Chain Management with AIBased Tools in the Inspection Machinery Industry
Empowering Supply Chain Management with AIBased Tools in the Inspection Machinery Industry Open
The manufacturing industry is increasingly adopting Artificial Intelligence (AI)-based solutions to improve production planning and operational efficiency. This article reflects the work carried out in the context of the AIDEAS project. AI…
View article: Left atrial appendage closure in patients with prior intracranial bleeding, safety, efficacy, and timing
Left atrial appendage closure in patients with prior intracranial bleeding, safety, efficacy, and timing Open
View article: The Role of a Nurse in a Programme for Patients Undergoing Transcatheter Aortic Valve Implantation: Impact on Outcomes and Patient Experience
The Role of a Nurse in a Programme for Patients Undergoing Transcatheter Aortic Valve Implantation: Impact on Outcomes and Patient Experience Open
Background/Objectives: Multidisciplinary TAVI programs are focused on improving patient-centred care. We compared outcomes in patients undergoing transcatheter aortic valve implantation (TAVI) within a multidisciplinary programme including…
View article: CheXGenBench: A Unified Benchmark For Fidelity, Privacy and Utility of Synthetic Chest Radiographs
CheXGenBench: A Unified Benchmark For Fidelity, Privacy and Utility of Synthetic Chest Radiographs Open
We introduce CheXGenBench, a rigorous and multifaceted evaluation framework for synthetic chest radiograph generation that simultaneously assesses fidelity, privacy risks, and clinical utility across state-of-the-art text-to-image generati…
View article: Successful intubation with a flexible optical stylet in a patient with predictors of difficult airway using pharyngeal clearance technique with a laryngoscope: A case report
Successful intubation with a flexible optical stylet in a patient with predictors of difficult airway using pharyngeal clearance technique with a laryngoscope: A case report Open
General anesthesia (GA) is associated with risks, including inadequate ventilation, which significantly contributes to morbidity and mortality. A difficult airway (DA) is characterized by the inability to achieve adequate ventilation and o…
View article: Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)
Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses) Open
View article: Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac monitoring device with real-time transmission—the TeVeO study protocol
Prospective study of continuous rhythm monitoring in patients with early post-infarction systolic dysfunction: clinical impact of arrhythmias detected by an implantable cardiac monitoring device with real-time transmission—the TeVeO study protocol Open
Introduction Updated primary prevention strategies are needed for post-infarction sudden cardiac death (SCD) based on implantable cardioverter-defibrillator (ICD). Current recommendations, based on left ventricular systolic function and fu…
View article: The Role of the BMPR2 pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease
The Role of the BMPR2 pathway in Group-II Pulmonary Hypertension Secondary to Valve Heart Disease Open
BMPR2 is widely known to be key in the pathobiology of pulmonary arterial hypertension. Recently, data regarding pulmonary hypertension (PH) secondary to left-heart disease (LHD) have focused on inflammatory and proliferative pathways rath…
View article: Visual Pathways to AI Literacy: Challenges and Lessons Learned in the Medical Domain (Preprint)
Visual Pathways to AI Literacy: Challenges and Lessons Learned in the Medical Domain (Preprint) Open
UNSTRUCTURED Artificial Intelligence (AI) is becoming increasingly popular in medical research for its perceived advantages in accuracy and dealing with large quantities of data. However, healthcare professionals are rarely experts in AI,…
View article: Confounder-aware foundation modeling for accurate phenotype profiling in cell imaging
Confounder-aware foundation modeling for accurate phenotype profiling in cell imaging Open
Image-based profiling is rapidly transforming drug discovery, offering unprecedented insights into cellular responses. However, experimental variability hinders accurate identification of mechanisms of action (MoA) and compound targets. Ex…
View article: Prognostic influence of the neurological complications in patients supported with venoarterial extracorporeal membrane oxygenation
Prognostic influence of the neurological complications in patients supported with venoarterial extracorporeal membrane oxygenation Open
Background Neurologic injuries including ischemic or hemorrhagic stroke and hypoxic-ischemic encephalopathy are common in patients supported with venoarterial extracorporeal membrane oxygenation (VA-ECMO). Purpose Our objective was to anal…
View article: Ramipril After Transcatheter Aortic Valve Implantation in Patients Without Reduced Ejection Fraction: The RASTAVI Randomized Clinical Trial
Ramipril After Transcatheter Aortic Valve Implantation in Patients Without Reduced Ejection Fraction: The RASTAVI Randomized Clinical Trial Open
Background Patients with aortic stenosis may continue to have an increased risk of heart failure, arrhythmias, and death after successful transcatheter aortic valve implantation. Renin‐angiotensin system inhibitors may be beneficial in thi…
View article: Cierre percut�neo de fuga paravalvular mitral con el dispositivo oclusor KONAR
Cierre percut�neo de fuga paravalvular mitral con el dispositivo oclusor KONAR Open
Varón de 70 años con antecedente de reemplazo valvular aórtico y mitral (Björk-Shiley, Pfizer, Estados Unidos) en 1976, y un segundo reemplazo valvular aórtico (On-X, On-X Life Technologies, Estados Unidos) con anuloplastia tricuspídea en …
View article: Encorafenib and binimetinib followed by radiotherapy for patients with BRAFV600-mutant melanoma and brain metastases (E-BRAIN/GEM1802 phase II study)
Encorafenib and binimetinib followed by radiotherapy for patients with BRAFV600-mutant melanoma and brain metastases (E-BRAIN/GEM1802 phase II study) Open
Background Encorafenib plus binimetinib (EB) is a standard-of-care treatment for advanced BRAFV600-mutant melanoma. We assessed the efficacy and safety of encorafenib plus binimetinib in patients with BRAFV600-mutant melanoma and brain met…
View article: Mastoparan-7 adjuvanted COBRA H1 and H3 hemagglutinin influenza vaccines
Mastoparan-7 adjuvanted COBRA H1 and H3 hemagglutinin influenza vaccines Open
Adjuvants enhance, prolong, and modulate immune responses by vaccine antigens to maximize protective immunity and enable more effective immunization in the young and elderly. Most adjuvants are formulated with injectable vaccines. However,…
View article: Colchicine in acute heart failure: Rationale and design of a randomized double‐blind placebo‐controlled trial (<scp>COLICA</scp>)
Colchicine in acute heart failure: Rationale and design of a randomized double‐blind placebo‐controlled trial (<span>COLICA</span>) Open
Aims Heart failure (HF) elicits a pro‐inflammatory state, which is associated with impaired clinical outcomes, but no anti‐inflammatory therapies have demonstrated a clinical benefit yet. Inflammatory pathways related with the interleukin‐…
View article: Resultados de un servicio ininterrumpido de implante urgente de marcapasos permanente
Resultados de un servicio ininterrumpido de implante urgente de marcapasos permanente Open
View article: Variable Penetrance and Expressivity of a Rare Pore Loss-of-Function Mutation (p.L889V) of Nav1.5 Channels in Three Spanish Families
Variable Penetrance and Expressivity of a Rare Pore Loss-of-Function Mutation (p.L889V) of Nav1.5 Channels in Three Spanish Families Open
A novel rare mutation in the pore region of Nav1.5 channels (p.L889V) has been found in three unrelated Spanish families that produces quite diverse phenotypic manifestations (Brugada syndrome, conduction disease, dilated cardiomyopathy, s…
View article: Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines
Advax-SM™-Adjuvanted COBRA (H1/H3) Hemagglutinin Influenza Vaccines Open
Adjuvants enhance immune responses stimulated by vaccines. To date, many seasonal influenza vaccines are not formulated with an adjuvant. In the present study, the adjuvant Advax-SM™ was combined with next generation, broadly reactive infl…
View article: N‐terminal pro‐B‐type natriuretic peptide post‐discharge monitoring in the management of patients with heart failure and preserved ejection fraction – a randomized trial: The <scp>NICE</scp> study
N‐terminal pro‐B‐type natriuretic peptide post‐discharge monitoring in the management of patients with heart failure and preserved ejection fraction – a randomized trial: The <span>NICE</span> study Open
Aims There is a lack of specific studies assessing the impact of natriuretic peptide monitoring in the post‐discharge management of patients with heart failure (HF) and preserved ejection fraction (HFpEF), throughout the vulnerable phase f…
View article: Predicting survival with scales for in-hospital extracorporeal cardiopulmonary resuscitation
Predicting survival with scales for in-hospital extracorporeal cardiopulmonary resuscitation Open
Funding Acknowledgements None. Background Extracorporeal cardiopulmonary resuscitation (ECPR) is a rescue option in cardiac arrest (CA) refractory to advanced life support. Patient selection is challenging, and anecdotal scores are specifi…
View article: Assessing the Effectiveness of Textual Recommendations in KoopaML
Assessing the Effectiveness of Textual Recommendations in KoopaML Open
Artificial intelligence (AI) integration, notably in healthcare, has been significant, yet effective implementation in critical areas requires expertise. KoopaML, a previously developed visual platform, aims at bridging this gap, enabling …