Peeter Padrik
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View article: Guidance for the Clinical Use of the Breast Cancer Polygenic Risk Scores
Guidance for the Clinical Use of the Breast Cancer Polygenic Risk Scores Open
Background/Objectives: Polygenic risk scores (PRSs) have been extensively studied and are increasingly applied in healthcare. One of the most studied and developed areas is predictive medicine for breast cancer, but there is no wider conse…
View article: Guidance for the Clinical Use of the Breast Cancer Polygenic Risk Score
Guidance for the Clinical Use of the Breast Cancer Polygenic Risk Score Open
Background/Objectives: Polygenic risk scores (PRSs) have been extensively studied and are in-creasingly applied in healthcare. One of the most studied and developed areas is predictive med-icine for breast cancer, but there is no wider con…
View article: An implementation study of the service model for genetic risk-based stratified breast cancer screening – Estonian results of the BRIGHT project
An implementation study of the service model for genetic risk-based stratified breast cancer screening – Estonian results of the BRIGHT project Open
Breast cancer (BC) remains the most common malignant tumor site and the leading cause of cancer-related deaths in women despite the wide availability of screening programs and personalized treatment options. The BRIGHT study tested a genet…
View article: A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population
A Breast Cancer Polygenic Risk Score Is Feasible for Risk Stratification in the Norwegian Population Open
Background: Statistical associations of numerous single nucleotide polymorphisms with breast cancer (BC) have been identified in genome-wide association studies (GWAS). Recent evidence suggests that a Polygenic Risk Score (PRS) can be a us…
View article: Implementation of Risk-Stratified Breast Cancer Prevention With a Polygenic Risk Score Test in Clinical Practice
Implementation of Risk-Stratified Breast Cancer Prevention With a Polygenic Risk Score Test in Clinical Practice Open
Background: Breast cancer (BC) screening with mammography reduces mortality but considers currently only age as a risk factor. Personalized risk-based screening has been proposed as a more efficient alternative. For that, risk prediction t…
View article: Precise, Genotype-First Breast Cancer Prevention: Experience With Transferring Monogenic Findings From a Population Biobank to the Clinical Setting
Precise, Genotype-First Breast Cancer Prevention: Experience With Transferring Monogenic Findings From a Population Biobank to the Clinical Setting Open
Although hereditary breast cancer screening and management are well accepted and established in clinical settings, these efforts result in the detection of only a fraction of genetic predisposition at the population level. Here, we describ…
View article: Identification of Bull Semen Microbiome by 16S Sequencing and Possible Relationships with Fertility
Identification of Bull Semen Microbiome by 16S Sequencing and Possible Relationships with Fertility Open
Reports on the use of 16S sequencing for the identification of bacteria in healthy animals are lacking. Bacterial contamination of bull semen can have a negative effect on the sperm quality. The aims of this study were threefold: to identi…
View article: Stable bull fertility protein markers in seminal plasma
Stable bull fertility protein markers in seminal plasma Open
Bull fertility is an important trait in breeding as the semen of one bull can, potentially, be used to perform thousands of inseminations. The high number of inseminations needed to obtain reliable measures from Non-Return Rates to oestrus…
View article: Recommendations for Primary Prevention of Skin Melanoma
Recommendations for Primary Prevention of Skin Melanoma Open
Melanoma (MEL) is an aggressive form of skin cancer, causing over 60,000 deaths every year and it is considered one of the fastest-growing cancer forms. Genome-wide association studies have identified numerous genetic variants (SNPs) indep…
View article: Precision Prostate Cancer Screening with a Polygenic Risk Score
Precision Prostate Cancer Screening with a Polygenic Risk Score Open
Prostate cancer (PC) is the second-most common type of cancer and the fifth-leading cause of cancer-related death in men worldwide. Genome-wide association studies have identified numerous genetic variants (SNPs) independently associated w…
View article: Precision Colorectal Cancer Screening with Polygenic Risk Score
Precision Colorectal Cancer Screening with Polygenic Risk Score Open
Colorectal cancer (CRC) is the second most common cancer in women and third most common cancer in men. Genome-wide association studies have identified numerous genetic variants (SNPs) independently associated with CRC. The effects of such …
View article: Precision Breast Cancer Screening with a Polygenic Risk Score
Precision Breast Cancer Screening with a Polygenic Risk Score Open
Breast cancer (BC) is the leading cause of cancer deaths in women in the world. Genome-wide association studies have identified numerous genetic variants (SNPs) independently associated with BC. The effects of such SNPs can be combined int…
View article: Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants
Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants Open
Genotype-first approach allows to systematically identify carriers of pathogenic variants in BRCA1 / 2 genes conferring a high risk of familial breast and ovarian cancer. Participants of the Estonian biobank have expressed support for the …
View article: A dual colour FISH method for routine validation of sexed Bos taurus semen
A dual colour FISH method for routine validation of sexed Bos taurus semen Open
A protocol for a dual colour bovine sperm FISH method is provided which is cost-effective, simple and fast for sex determination of spermatozoa in bull semen samples.
View article: Additional file 1: of Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification
Additional file 1: of Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification Open
Table S1. Cohort characteristics of UK Biobank and Estonian Biobank. Table S2. Associations of breast cancer and standardized GRSs in the UK Biobank (with and without adjustment of family history) and in Estonian Biobank without family his…
View article: Factors Influencing the Quality of Frozen/Thawed Semen from Estonian Holstein AI Bulls, and Relationships between Semen Quality Parameters and in vivo Fertility
Factors Influencing the Quality of Frozen/Thawed Semen from Estonian Holstein AI Bulls, and Relationships between Semen Quality Parameters and in vivo Fertility Open
At present, dairy farming is definitely the most profitable sector of Estonia’s cattle industry. The effectiveness of milk production is dependent not only on the availability of high-quality genetic material but also on several other fact…
View article: Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening
Polygenic prediction of breast cancer: comparison of genetic predictors and implications for screening Open
Background Published genetic risk scores for breast cancer (BC) so far have been based on a relatively small number of markers and are not necessarily using the full potential of large-scale Genome-Wide Association Studies. This study aims…
View article: Increasing kidney cancer incidence and survival in Estonia: role of age and stage
Increasing kidney cancer incidence and survival in Estonia: role of age and stage Open
Estonia is currently among countries with the highest incidence of kidney cancer. The results suggest a combined effect of changing risk profiles in successive birth cohorts and increasing diagnostic activity around 1990. Large survival in…
View article: An anaplastic lymphoma kinase (ALK) fusion oncogene positive metastatic sarcomatoid carcinoma of the lung with good response to crizotinib
An anaplastic lymphoma kinase (ALK) fusion oncogene positive metastatic sarcomatoid carcinoma of the lung with good response to crizotinib Open
Primary sarcomatoid carcinoma (SC) of the lung is a rare tumor that accounts for less than 1% of all lung cancers and compared to other non-small cell lung cancers (NSCLC) they appear more aggressive with poorer prognosis and response to t…
View article: Effect of insemination-related factors on pregnancy rate using sexed semen in Holstein heifers
Effect of insemination-related factors on pregnancy rate using sexed semen in Holstein heifers Open
The objectives were to determine the effects of insemination with sexed semen at spontaneous and induced estrus, fixed-time insemination at synchronized estrus, the deposition site, estrous intensity, housing, age, body weight, and bull on…
View article: Trends in incidence and survival of cutaneous malignant melanoma in Estonia: a population-based study
Trends in incidence and survival of cutaneous malignant melanoma in Estonia: a population-based study Open
The proportion of stage I and T1 cases is lower in Estonia compared with the Scandinavian data and is likely a major contributor to the persisting overall survival deficit in Estonia. The apparent deficit in stage II survival also warrants…