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View article: Magnetoencephalography Atlas Viewer for Dipole Localization and Viewing
Magnetoencephalography Atlas Viewer for Dipole Localization and Viewing Open
Magnetoencephalography (MEG) is a noninvasive neuroimaging technique widely recognized for epilepsy and tumor mapping. MEG clinical reporting requires a multidisciplinary team, including expert input regarding each dipole’s anatomic locali…
View article: Magnetoencephalography (MEG) Data Processing in Epilepsy Patients with Implanted Responsive Neurostimulation (RNS) Devices
Magnetoencephalography (MEG) Data Processing in Epilepsy Patients with Implanted Responsive Neurostimulation (RNS) Devices Open
Drug-resistant epilepsy (DRE) is often treated with surgery or neuromodulation. Specifically, responsive neurostimulation (RNS) is a widely used therapy that is programmed to detect abnormal brain activity and intervene with tailored stimu…
View article: An Investigation of Quantitative Measures of Sleep-Apnea-Induced Nocturnal Cardiac Stress
An Investigation of Quantitative Measures of Sleep-Apnea-Induced Nocturnal Cardiac Stress Open
Obstructive Sleep Apnea (OSA) affects an estimated 18 million individuals in the U.S. adult population. Numerous research findings indicate that OSA has significant adverse effects on the cardiac health. Current method of assessing the sev…
View article: NIMG-29. ELEVATION OF GLUTAMINE AND CITRATE BY MR SPECTROSCOPY IS AN IMAGING BIOMARKER OF RAPID CELL PROLIFERATION IN GLIOMAS
NIMG-29. ELEVATION OF GLUTAMINE AND CITRATE BY MR SPECTROSCOPY IS AN IMAGING BIOMARKER OF RAPID CELL PROLIFERATION IN GLIOMAS Open
Prior studies suggested glutamine metabolism in cancers may be altered to meet the high demands of nucleotide biosynthesis in cancers. We conducted 1H MR spectroscopy in 18 glioma patients and analyzed the metabolic data together with post…
View article: Spectral fitting strategy to overcome the overlap between 2‐hydroxyglutarate and lipid resonances at 2.25 ppm
Spectral fitting strategy to overcome the overlap between 2‐hydroxyglutarate and lipid resonances at 2.25 ppm Open
Purpose 1 H MRS provides a noninvasive tool for identifying mutations in isocitrate dehydrogenase (IDH). Quantification of the prominent 2‐hydroxyglutarate (2HG) resonance at 2.25 ppm is often confounded by the lipid resonance at the same …
View article: BIMG-09. GLUTAMINE AND GLYCINE BY MR SPECTROSCOPY IDENTIFY AGGRESSIVE GLIOMAS
BIMG-09. GLUTAMINE AND GLYCINE BY MR SPECTROSCOPY IDENTIFY AGGRESSIVE GLIOMAS Open
Cancers reprogram their metabolism and the resulting alterations in metabolite abundance can be monitored in patients noninvasively using proton magnetic resonance spectroscopy (MRS). We evaluated glutamine, glycine and 2-hydroxyglutarate …
View article: NIMG-24. GLYCINE AND GLUTAMINE BY MR SPECTROSCOPY ARE IMAGING BIOMARKERS OF GLIOMA AGGRESSIVENESS
NIMG-24. GLYCINE AND GLUTAMINE BY MR SPECTROSCOPY ARE IMAGING BIOMARKERS OF GLIOMA AGGRESSIVENESS Open
Cancers reprogram their metabolism and the resulting alterations in metabolite concentrations may be closely related to the clinical behavior of the tumors. We evaluated glycine, glutamine and 2-hydroxyglutarate (2HG) in 16 adult subjects …
View article: Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness
Glycine by MR spectroscopy is an imaging biomarker of glioma aggressiveness Open
Background High-grade gliomas likely remodel the metabolic machinery to meet the increased demands for amino acids and nucleotides during rapid cell proliferation. Glycine, a non-essential amino acid and intermediate of nucleotide biosynth…
View article: In vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients
In vivo MRS measurement of 2‐hydroxyglutarate in patient‐derived IDH‐mutant xenograft mouse models versus glioma patients Open
Purpose To generate a preclinical model of isocitrate dehydrogenase (IDH) mutant gliomas from glioma patients and design a MRS method to test the compatibility of 2‐hydroxyglutarate (2HG) production between the preclinical model and patien…