Peggy Mérida
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View article: Extracellular vesicles containing the I‐BAR protein IRSp53 are released from the cell plasma membrane in an Arp2/3 dependent manner
Extracellular vesicles containing the I‐BAR protein IRSp53 are released from the cell plasma membrane in an Arp2/3 dependent manner Open
Backgroud Extracellular vesicles (EVs) are nanometric membrane vesicles produced by cells and involved in cell–cell communication. EV formation can occur in endosomal compartments whose budding depends on the ESCRT machinery (i.e., exosome…
View article: Optimized production and fluorescent labelling of SARS-CoV-2 Virus-Like-Particles to study virus assembly and entry
Optimized production and fluorescent labelling of SARS-CoV-2 Virus-Like-Particles to study virus assembly and entry Open
SARS-CoV-2 is an RNA enveloped virus responsible for the COVID-19 pandemia that conducted in 6 million deaths worldwide so far. SARS-CoV-2 particles are mainly composed of the 4 main structural proteins M, N, E and S to form 100nm diameter…
View article: Specific Intracellular Signature of SARS-CoV-2 Infection Using Confocal Raman Microscopy
Specific Intracellular Signature of SARS-CoV-2 Infection Using Confocal Raman Microscopy Open
SARS-CoV-2 infection remains to spread worldwide and requires a better understanding of virus-host interactions. Here, we analyzed biochemical modifications due to SARS-CoV-2 infection in cells by confocal Raman microscopy. Obtained result…
View article: Low Selectivity Indices of Ivermectin and Macrocyclic Lactones on SARS-CoV-2 Replication In Vitro
Low Selectivity Indices of Ivermectin and Macrocyclic Lactones on SARS-CoV-2 Replication In Vitro Open
Ivermectin was first approved for human use as an endectocide in the 1980s. It remains one of the most important global health medicines in history and has recently been shown to exert in vitro activity against SARS-CoV-2. However, the mac…
View article: SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects
SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects Open
Various neurological symptoms have been associated to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection including headache, fever, anosmia, ageusia, but also, encephalitis, Guillain-Barre syndrome and ischemic stroke. …
View article: Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53
Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53 Open
During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of HIV-1 membrane…
View article: Author response: Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53
Author response: Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53 Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract During HIV-1 particle formation, the requi…
View article: Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53
Full assembly of HIV-1 particles requires assistance of the membrane curvature factor IRSp53 Open
During HIV-1 particle formation, the requisite plasma membrane curvature is thought to be solely driven by the retroviral Gag protein. Here, we reveal that the cellular I-BAR protein IRSp53 is required for the progression of HIV-1 membrane…
View article: HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly
HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly Open
HIV-1 is creating its own lipid bed for assembly.
View article: HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly
HIV-1 Gag specifically restricts PI(4,5)P2 and cholesterol mobility in living cells creating a nanodomain platform for virus assembly Open
HIV-1 Gag protein self-assembles at the plasma membrane of infected cells for viral particle formation. Gag targets lipids, mainly the phosphatidylinositol (4, 5) bisphosphate, at the inner leaflet of this membrane. Here, we address the qu…
View article: Author Correction: Single molecule localisation microscopy reveals how HIV-1 Gag proteins sense membrane virus assembly sites in living host CD4 T cells
Author Correction: Single molecule localisation microscopy reveals how HIV-1 Gag proteins sense membrane virus assembly sites in living host CD4 T cells Open
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
View article: Live single molecule microscopy of HIV-1 assembly in host T cells reveals a spatio-temporal effect of the viral genome
Live single molecule microscopy of HIV-1 assembly in host T cells reveals a spatio-temporal effect of the viral genome Open
Monitoring virus assembly dynamic at the nanoscale level in host cells remains a major challenge. Human Immunodeficiency Virus type 1 (HIV-1) components are addressed to the plasma membrane where they assemble to form spherical particles o…