Peggy Roberts
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View article: Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
Correction: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population Open
View article: Polygenic effects on the risk of Alzheimer’s disease in the Japanese population
Polygenic effects on the risk of Alzheimer’s disease in the Japanese population Open
Background Polygenic effects have been proposed to account for some disease phenotypes; these effects are calculated as a polygenic risk score (PRS). This score is correlated with Alzheimer’s disease (AD)-related phenotypes, such as biomar…
View article: Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration
Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration Open
Background The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 (i.e. Triggering receptor expressed on myeloid cells 2) is a microglial transmembrane protein brain th…
View article: Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways
Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways Open
View article: A blood-based signature of cerebrospinal fluid Aβ1–42 status
A blood-based signature of cerebrospinal fluid Aβ1–42 status Open
It is increasingly recognized that Alzheimer’s disease (AD) exists before dementia is present and that shifts in amyloid beta occur long before clinical symptoms can be detected. Early detection of these molecular changes is a key aspect f…
View article: Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images
Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer’s Disease using structural MR and FDG-PET images Open
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and…
View article: Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states
Brain multiplexes reveal morphological connectional biomarkers fingerprinting late brain dementia states Open
Accurate diagnosis of mild cognitive impairment (MCI) before conversion to Alzheimer’s disease (AD) is invaluable for patient treatment. Many works showed that MCI and AD affect functional and structural connections between brain regions a…
View article: Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features
Cascaded Multi-view Canonical Correlation (CaMCCo) for Early Diagnosis of Alzheimer’s Disease via Fusion of Clinical, Imaging and Omic Features Open
The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer’s Disease (AD). No single marker has been proven to accurately categorize patients into their respective diagnostic…
View article: Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease
Mining Outcome-relevant Brain Imaging Genetic Associations via Three-way Sparse Canonical Correlation Analysis in Alzheimer’s Disease Open
View article: Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease
Longitudinal measurement and hierarchical classification framework for the prediction of Alzheimer’s disease Open
View article: Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts
Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts Open
The Clusterin ( CLU ) gene, also known as apolipoprotein J ( ApoJ ), is currently the third most associated late-onset Alzheimer’s disease (LOAD) risk gene. However, little was known about the possible effect of CLU genetic variants on AD …
View article: The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum
The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum Open
Phosphatidylinositolbinding clathrin assembly protein (PICALM) gene is one novel genetic player associated with late-onset Alzheimer’s disease (LOAD), based on recent genome wide association studies (GWAS). However, how it affects AD occur…
View article: Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI
Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI Open
Overall, image analysis problems do not appear to be a primary explanation of amyloid negativity. Florbetapir- ADNI patients have a variety of clinical and biomarker features that differ from their florbetapir+ counterparts, suggesting tha…