Hao Zhou
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View article: Computational Discovery of Aggregation-Mediated Dipeptide Inhibitors Targeting PHLDA1 for Cardiovascular Therapy
Computational Discovery of Aggregation-Mediated Dipeptide Inhibitors Targeting PHLDA1 for Cardiovascular Therapy Open
Cardiovascular disease remains a leading cause of global mortality, underscoring the urgent need for novel therapeutic strategies. This study focuses on the pleckstrin homology-like domain family A member 1-encoded protein (PEP), a regulat…
View article: Review of Preparation and Key Functional Properties of Micro-Arc Oxidation Coatings on Various Metal Substrates
Review of Preparation and Key Functional Properties of Micro-Arc Oxidation Coatings on Various Metal Substrates Open
Micro-arc oxidation (MAO) technology demonstrates remarkable advantages in fabricating ceramic coatings on lightweight alloys. For aluminum alloys, MAO rapidly forms dense, pore-free ceramic layers within minutes, significantly enhancing c…
View article: Metal–hydrogel chelation interfaces for ultrasoft and bidirectional bioelectronics
Metal–hydrogel chelation interfaces for ultrasoft and bidirectional bioelectronics Open
Emerging demand in soft bioelectronic systems poses critical challenges in stiffness control and end-to-end connections due to the huge modulus difference in various components. Here, a bidirectional electrical interface of hydrogel and me…
View article: Review of Preparation and Performance of Micro-Arc Oxidation Coatings on Various Metal Substrates
Review of Preparation and Performance of Micro-Arc Oxidation Coatings on Various Metal Substrates Open
Micro-arc oxidation (MAO) technology demonstrates remarkable advantages in fabricating ceramic coatings on lightweight alloys. For aluminum alloys, MAO rapidly forms dense, pore-free ceramic layers within minutes, significantly enhancing c…
View article: Efficient removal of trace diazepam via enhanced peroxymonosulfate activation by 1T-phase and sulfur vacancy-rich MoS2-C-Fe
Efficient removal of trace diazepam via enhanced peroxymonosulfate activation by 1T-phase and sulfur vacancy-rich MoS2-C-Fe Open
View article: In Silico Screening of Peptide Inhibitors of PHLDA1-Encoded Protein Targeting Cardiovascular Diseases
In Silico Screening of Peptide Inhibitors of PHLDA1-Encoded Protein Targeting Cardiovascular Diseases Open
The PHLDA1-encoded protein (PEP) is a pivotal regulator of cardiomyocyte apoptosis and a promising therapeutic target for cardiovascular diseases. Leveraging in silico approaches, we characterized PEP's structure using AlphaFold3 (AF3) and…
View article: Analysis of the migration patterns of sand particles below the screw pump in wells based on experiments and numerical simulations
Analysis of the migration patterns of sand particles below the screw pump in wells based on experiments and numerical simulations Open
View article: Computational Design of Next-Gen Peptide Biopesticides: Targeting the Nicotinic Acetylcholine Receptor in Rice Pests
Computational Design of Next-Gen Peptide Biopesticides: Targeting the Nicotinic Acetylcholine Receptor in Rice Pests Open
The brown planthopper ( Nilaparvata lugens ) threatens global rice production, and conventional pesticides face resistance and environmental challenges. We present a computational framework integrating AlphaFold3-predicted structure of the…
View article: Trusted Fake Audio Detection Based on Dirichlet Distribution
Trusted Fake Audio Detection Based on Dirichlet Distribution Open
With the continuous development of deep learning-based speech conversion and speech synthesis technologies, the cybersecurity problem posed by fake audio has become increasingly serious. Previously proposed models for defending against fak…
View article: Progress in Surface Engineering Techniques for Magnesium–Lithium-Based Alloys
Progress in Surface Engineering Techniques for Magnesium–Lithium-Based Alloys Open
Magnesium–lithium alloys, currently the lightest metallic structural materials, exhibit exceptional specific strength, superior damping capacity, and remarkable electromagnetic shielding properties. These characteristics endow them with si…
View article: APPLICATION OF ATOMIC FORCE MICROSCOPY IN PREPARED Ni-Al LAYER BY A TWO-STAGE PROCESS
APPLICATION OF ATOMIC FORCE MICROSCOPY IN PREPARED Ni-Al LAYER BY A TWO-STAGE PROCESS Open
A Ni-Al layer can provide substrate properties and has received widespread attention. This study investigates the morphology and composition of a Ni-Al layer fabricated on a steel substrate using a two-step method. Initially, an internal n…
View article: SpaceR: Reinforcing MLLMs in Video Spatial Reasoning
SpaceR: Reinforcing MLLMs in Video Spatial Reasoning Open
Video spatial reasoning, which involves inferring the underlying spatial structure from observed video frames, poses a significant challenge for existing Multimodal Large Language Models (MLLMs). This limitation stems primarily from 1) the…
View article: A novel lubricating method of oil pump with self-adaptive adjustment function for transmission
A novel lubricating method of oil pump with self-adaptive adjustment function for transmission Open
At present, the lubrication of transmission in vehicles cannot be adjusted according to driving conditions, especially vehicles' speed, resulting in low lubrication efficiency and high energy loss. This paper aims to develop a mechatronic …
View article: A Recyclable Rh(III)‐Catalyzed C−H Annulation of <i>N</i>‐Pyrimidinyl Aryl Amines with Cyclic 1,3‐Diones in Water
A Recyclable Rh(III)‐Catalyzed C−H Annulation of <i>N</i>‐Pyrimidinyl Aryl Amines with Cyclic 1,3‐Diones in Water Open
Rh(III)‐catalyzed synthesis of N ‐heterocycles via regioselective C−H bond activation is both highly efficient and atom‐economical but often hindered by the use of toxic solvents and limited catalyst recyclability. Herein, we present a rec…
View article: Progress in Surface Engineering Techniques for Magnesium-Lithium-Based Alloys
Progress in Surface Engineering Techniques for Magnesium-Lithium-Based Alloys Open
Magnesium-lithium alloys, currently the lightest metallic structural materials, exhibit exceptional specific strength, superior damping capacity, and remarkable electromagnetic shielding properties. These characteristics endow them with si…
View article: Steering Protein Family Design through Profile Bayesian Flow
Steering Protein Family Design through Profile Bayesian Flow Open
Protein family design emerges as a promising alternative by combining the advantages of de novo protein design and mutation-based directed evolution.In this paper, we propose ProfileBFN, the Profile Bayesian Flow Networks, for specifically…
View article: A Periodic Bayesian Flow for Material Generation
A Periodic Bayesian Flow for Material Generation Open
Generative modeling of crystal data distribution is an important yet challenging task due to the unique periodic physical symmetry of crystals. Diffusion-based methods have shown early promise in modeling crystal distribution. More recentl…
View article: CVaR-Based Variational Quantum Optimization for User Association in Handoff-Aware Vehicular Networks
CVaR-Based Variational Quantum Optimization for User Association in Handoff-Aware Vehicular Networks Open
View article: CVaR-Based Variational Quantum Optimization for User Association in Handoff-Aware Vehicular Networks
CVaR-Based Variational Quantum Optimization for User Association in Handoff-Aware Vehicular Networks Open
Efficient resource allocation is essential for optimizing various tasks in wireless networks, which are usually formulated as generalized assignment problems (GAP). GAP, as a generalized version of the linear sum assignment problem, involv…
View article: Femtosecond-Laser-Fabricated Low-Loss and High-Beam-Quality Parabolic Graded Waveguides in Sapphire
Femtosecond-Laser-Fabricated Low-Loss and High-Beam-Quality Parabolic Graded Waveguides in Sapphire Open
View article: Visual Experimental Study on the Dynamic Ash Deposition Evolution of Zhundong Coal Co-Combustion with Iron-Rich Coal and Kaolin
Visual Experimental Study on the Dynamic Ash Deposition Evolution of Zhundong Coal Co-Combustion with Iron-Rich Coal and Kaolin Open
View article: Investigation on Co-Combustion Characteristics of Fe/Ca-Rich Zhundong Coal with High-ash Low-Calorific-Value Coal: Combustion Behavior, Ash Fusion and Slagging Properties
Investigation on Co-Combustion Characteristics of Fe/Ca-Rich Zhundong Coal with High-ash Low-Calorific-Value Coal: Combustion Behavior, Ash Fusion and Slagging Properties Open
View article: 基于飞秒激光增强湿法刻蚀制备的光波导研究进展
基于飞秒激光增强湿法刻蚀制备的光波导研究进展 Open
View article: Electrospun Fe/Zn Co-Doped Porous Carbon Nanofibers: Dual-Functional Catalysts for High-Efficiency Oxygen Reduction and Ultra-Stable Supercapacitors
Electrospun Fe/Zn Co-Doped Porous Carbon Nanofibers: Dual-Functional Catalysts for High-Efficiency Oxygen Reduction and Ultra-Stable Supercapacitors Open
View article: PunchBench: Benchmarking MLLMs in Multimodal Punchline Comprehension
PunchBench: Benchmarking MLLMs in Multimodal Punchline Comprehension Open
View article: RLEM-Net: Reinforcement Learning Enhanced Multimodal Segmentation for Camellia oleifera Diseases Based on Semantic and Visual Features
RLEM-Net: Reinforcement Learning Enhanced Multimodal Segmentation for Camellia oleifera Diseases Based on Semantic and Visual Features Open
View article: PunchBench: Benchmarking MLLMs in Multimodal Punchline Comprehension
PunchBench: Benchmarking MLLMs in Multimodal Punchline Comprehension Open
Multimodal punchlines, which involve humor or sarcasm conveyed in image-caption pairs, are a popular way of communication on online multimedia platforms. With the rapid development of multimodal large language models (MLLMs), it is essenti…
View article: AI-Driven Accelerated Discovery of Intercalation-type Cathode Materials for Magnesium Batteries
AI-Driven Accelerated Discovery of Intercalation-type Cathode Materials for Magnesium Batteries Open
Magnesium-ion batteries hold promise as future energy storage solution, yet current Mg cathodes are challenged by low voltage and specific capacity. Herein, we present an AI-driven workflow for discovering high-performance Mg cathode mater…
View article: Penumbra-Effect Induced Spectral Mixing in X-ray Computed Tomography: A Multi-Ray Spectrum Estimation Model and Subsampled Weighting Algorithm
Penumbra-Effect Induced Spectral Mixing in X-ray Computed Tomography: A Multi-Ray Spectrum Estimation Model and Subsampled Weighting Algorithm Open
Purpose: With the development of spectral CT, several novel spectral filters have been introduced to modulate the spectra, such as split filters and spectral modulators. However, due to the finite size of the focal spot of X-ray source, th…
View article: Inter-scale Causality Relations in Wall Turbulence
Inter-scale Causality Relations in Wall Turbulence Open
We investigate the inter-scale energy transfer in the buffer layer between different streamwise and spanwise lengthscales. In a periodic channel, inter-scale transfer of momentum in the periodic directions is only possible through wavenumb…