Yongjun Tan
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View article: Effect of Mediterranean Diet on Type 2 Diabetes
Effect of Mediterranean Diet on Type 2 Diabetes Open
The incidence rate of type 2 diabetes (T2DM) is on the rise all over the world, and has become an increasingly serious global health problem. At present, people are actively seeking solutions to T2DM and have made many breakthroughs, such …
View article: Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction
Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction Open
JOURNAL/nrgr/04.03/01300535-202602000-00044/figure1/v/2025-05-17T081902Z/r/image-tiff Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However,…
View article: Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles
Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles Open
Extracellular vesicle DNAs (evDNAs) hold significant diagnostic value for various diseases and facilitate transcellular transfer of genetic material. Our study identifies transcription factor FOXM1 as a mediator for directing chromatin gen…
View article: Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1
Development of an interfering peptide M1-20 with potent anti-cancer effects by targeting FOXM1 Open
Disrupting protein–protein interactions (PPIs) has emerged as a promising strategy for cancer drug development. Interfering peptides disrupting PPIs can be rationally designed based on the structures of natural sequences mediating these in…
View article: Genome‐wide enhancer identification by massively parallel reporter assay in <i>Arabidopsis</i>
Genome‐wide enhancer identification by massively parallel reporter assay in <i>Arabidopsis</i> Open
SUMMARY Enhancers are critical cis‐regulatory elements controlling gene expression during cell development and differentiation. However, genome‐wide enhancer characterization has been challenging due to the lack of a well‐defined relations…
View article: Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis
Evolutionarily distinct and sperm-specific supersized chromatin loops are marked by Helitron transposons in Xenopus tropicalis Open
Transposable elements (TEs) are abundant in metazoan genomes and have multifaceted effects on host fitness. However, the mechanisms underlying the functions of TEs are still not fully understood. Here, we combine Hi-C, ATAC-seq, and ChIP-s…
View article: Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles
Transcription factor FOXM1 specifies chromatin DNA to extracellular vesicles Open
Extracellular vesicle DNAs (evDNAs) hold significant diagnostic value for various diseases and facilitate transcellular transfer of genetic material. Our study identifies transcription factor FOXM1 as a mediator for directing chromatin gen…
View article: Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles
Transcription factor FOXM1 specifies the loading of chromatin DNA to extracellular vesicles Open
Extracellular vesicle DNAs (evDNAs) possess the important diagnostic value for multiple diseases and play roles for horizontally transferring genetic materials among cells. In this study, we have found that transcription factor FOXM1 can m…
View article: Increased FOXA1 levels induce apoptosis and inhibit proliferation in FOXA1-low expressing basal breast cancer cells.
Increased FOXA1 levels induce apoptosis and inhibit proliferation in FOXA1-low expressing basal breast cancer cells. Open
The transcription factor FOXA1, which is a member of the forkhead class of DNA-binding proteins, interacts with Estrogen Receptor (ER) to mediate breast cancer progression. However, its role in basal breast cancer cells remains unclear. Al…
View article: The Expression of IbMYB1 Is Essential to Maintain the Purple Color of Leaf and Storage Root in Sweet Potato [Ipomoea batatas (L.) Lam]
The Expression of IbMYB1 Is Essential to Maintain the Purple Color of Leaf and Storage Root in Sweet Potato [Ipomoea batatas (L.) Lam] Open
IbMYB1 was one of the major anthocyanin biosynthesis regulatory genes that has been identified and utilized in purple-fleshed sweet potato breeding. At least three members of this gene, namely, IbMYB1-1 , -2a , and -2b , have been reported…
View article: Three-dimensional folding dynamics of the Xenopus tropicalis genome
Three-dimensional folding dynamics of the Xenopus tropicalis genome Open
Animal interphase chromosomes are organized into topologically associating domains (TADs). How TADs are formed is not fully understood. Here, we combined high-throughput chromosome conformation capture and gene silencing to obtain insights…
View article: FOXA2-Interacting FOXP2 Prevents Epithelial-Mesenchymal Transition of Breast Cancer Cells by Stimulating E-Cadherin and PHF2 Transcription
FOXA2-Interacting FOXP2 Prevents Epithelial-Mesenchymal Transition of Breast Cancer Cells by Stimulating E-Cadherin and PHF2 Transcription Open
FOXP2, a member of forkhead box transcription factor family, was first identified as a language-related gene that played an important role in language learning and facial movement. In addition, FOXP2 was also suggested regulating the progr…
View article: The cell-penetrating FOXM1 N-terminus (M1-138) demonstrates potent inhibitory effects on cancer cells by targeting FOXM1 and FOXM1-interacting factor SMAD3
The cell-penetrating FOXM1 N-terminus (M1-138) demonstrates potent inhibitory effects on cancer cells by targeting FOXM1 and FOXM1-interacting factor SMAD3 Open
M1-138 is a promising drug candidate for the development of anti-cancer therapeutics targeting FOXM1 and SMAD3.