Peinan Chen
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View article: Knowledge, attitudes, and practices of esophageal cancer patients regarding pulmonary rehabilitation training
Knowledge, attitudes, and practices of esophageal cancer patients regarding pulmonary rehabilitation training Open
Introduction This study aimed to assess the knowledge, attitudes, and practices (KAP) of esophageal cancer patients concerning pulmonary rehabilitation training. Methods A cross-sectional study was conducted at the Henan Cancer Hospital fr…
View article: Evaluating the efficacy of adjuvant chemotherapy in cT1b-T2 patients with incidentally discovered positive lymph nodes after esophagectomy for esophageal squamous cell carcinoma: a retrospective cohort study
Evaluating the efficacy of adjuvant chemotherapy in cT1b-T2 patients with incidentally discovered positive lymph nodes after esophagectomy for esophageal squamous cell carcinoma: a retrospective cohort study Open
View article: The Application of iPSCs in Tumour Immunotherapy
The Application of iPSCs in Tumour Immunotherapy Open
Background Tumour immunotherapy holds great promise as a treatment for cancer, which ranks as the second highest cause of mortality worldwide. This therapeutic approach can be broadly categorized into two main types: active immunotherapy a…
View article: The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma
The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma Open
Esophageal squamous cell carcinoma (ESCC) is highly heterogeneous. Our understanding of full molecular and immune landscape of ESCC remains limited, hindering the development of personalised therapeutic strategies. To address this, we perf…
View article: Exploring the potential cellular and molecular mechanisms of cuproptosis-related genes in cardiomyocytes from patients with dilated cardiomyopathy: a bioinformatics analysis
Exploring the potential cellular and molecular mechanisms of cuproptosis-related genes in cardiomyocytes from patients with dilated cardiomyopathy: a bioinformatics analysis Open
BACKGROUND Patients with dilated cardiomyopathy (DCM) often have heart failure, which seriously affects their health and quality of life. Some studies have suggested that DCM has a genetic basis, although the molecular mechanism involved h…
View article: Spatiotemporal Variations and Sustainability Characteristics of Groundwater Storage in North China from 2002 to 2022 Revealed by GRACE/GRACE Follow-On and Multiple Hydrologic Data
Spatiotemporal Variations and Sustainability Characteristics of Groundwater Storage in North China from 2002 to 2022 Revealed by GRACE/GRACE Follow-On and Multiple Hydrologic Data Open
North China (NC) is experiencing significant groundwater depletion. We used GRACE and GRACE-FO RL06 Level-2 data with Mascon data from April 2002 to July 2022. We fused these two types of data through the generalized three-cornered hat met…
View article: Multi-Omics Profiling Reveals Gene Signatures and Therapeutic Targets in HER2- Guided Gastric Cardia Adenocarcinoma Patients
Multi-Omics Profiling Reveals Gene Signatures and Therapeutic Targets in HER2- Guided Gastric Cardia Adenocarcinoma Patients Open
Therapeutic targets for Gastric Cardia Adenocarcinoma (GCA), particularly for HER2- negative patients, are lacking. Here, we conducted multi-omics profiling on 128 GCA patients using mass spectrometry, whole-exome sequencing, RNA-Seq, and …
View article: Correction: Neoadjuvant Chemotherapy or Adjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma
Correction: Neoadjuvant Chemotherapy or Adjuvant Chemotherapy for Esophageal Squamous Cell Carcinoma Open
View article: Left compared with right thoracic approach thoracotomy in esophageal cancer: a retrospective cohort study
Left compared with right thoracic approach thoracotomy in esophageal cancer: a retrospective cohort study Open
View article: Treatment outcomes of surgery and chemotherapy for pulmonary metastases from non-lung cancers: a propensity score-matched analysis
Treatment outcomes of surgery and chemotherapy for pulmonary metastases from non-lung cancers: a propensity score-matched analysis Open
Surgery does not provide a significant survival advantage. For patients undergoing surgery, longer DFI predicts better survival.
View article: β-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGF-β/Smad Signaling Pathway
β-Carboline Alkaloids From the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-pulmonary Fibrosis Agent That Inhibits TGF-β/Smad Signaling Pathway Open
Pulmonary fibrosis is a scarring disease of lung tissue, which seriously threatens human health. Treatment options are currently limited, and effective strategies are still lacking. In the present study, 25 compounds were isolated from the…
View article: Identification of a seven-cell cycle signature predicting overall survival for gastric cancer
Identification of a seven-cell cycle signature predicting overall survival for gastric cancer Open
While genetic alterations in several regulators of the cell cycle have a significant impact on the gastric carcinogenesis process, the prognostic role of them remains to be further elucidated. The TCGA-STAD training set were downloaded and…
View article: Predictive model of postoperative pneumonia after neoadjuvant immunochemotherapy for esophageal cancer
Predictive model of postoperative pneumonia after neoadjuvant immunochemotherapy for esophageal cancer Open
Our prediction model can predict the possibility of PP in patients with neoadjuvant immunochemotherapy for resectable esophageal squamous cell carcinoma and may facilitate physicians' efforts to reduce the incidence of postoperative pneumo…
View article: Estimation of Evapotranspiration in the Yellow River Basin from 2002 to 2020 Based on GRACE and GRACE Follow-On Observations
Estimation of Evapotranspiration in the Yellow River Basin from 2002 to 2020 Based on GRACE and GRACE Follow-On Observations Open
Evapotranspiration (ET) plays an important role in the hydrological cycle of river basins. Studying ET in the Yellow River Basin (YRB) is greatly significant for the scientific management of water resources. Here, we made full use of the a…
View article: Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network
Weighted gene co-expression network-based approach to identify key genes associated with anthracycline-induced cardiotoxicity and construction of miRNA-transcription factor-gene regulatory network Open
View article: Impact of nasogastric decompression on gastric tube size after McKeown minimally invasive esophagectomy: A retrospective controlled cohort study
Impact of nasogastric decompression on gastric tube size after McKeown minimally invasive esophagectomy: A retrospective controlled cohort study Open
Purpose: This retrospective study evaluated the impact of nasogastric decompression (NGD) on gastric tube size to optimize the Enhanced Recovery After Surgery protocol after McKeown minimally invasive esophagectomy (MIE). Methods: Overall,…
View article: Adjuvant Chemotherapy for Node-positive Esophageal Squamous Cell Carcinoma Improves Survival
Adjuvant Chemotherapy for Node-positive Esophageal Squamous Cell Carcinoma Improves Survival Open
Postoperative adjuvant chemotherapy improves the overall survival and disease-free survival of patients with resected esophageal squamous cell carcinoma with positive lymph nodes.
View article: Stemness and NK-like signatures define a subtype of esophageal squamous cell carcinoma with poor prognosis
Stemness and NK-like signatures define a subtype of esophageal squamous cell carcinoma with poor prognosis Open
To explore the biology of esophageal squamous cell carcinoma (ESCC) and identify new therapeutic opportunities, comprehensive genomic-transcriptomic characterizations of 120 Chinese ESCC patients were performed. Here we show that ESCC can …
View article: Effects of pyrolysis temperature, feedstock type and compaction on water retention of biochar amended soil
Effects of pyrolysis temperature, feedstock type and compaction on water retention of biochar amended soil Open
View article: Influence of soil density on gas permeability and water retention in soils amended with in-house produced biochar
Influence of soil density on gas permeability and water retention in soils amended with in-house produced biochar Open
Biochar has been used as an environment-friendly enhancer to improve the hydraulic properties (e.g. suction and water retention) of soil. However, variations in densities alter the properties of the soil–biochar mix. Such density variation…
View article: A phase III study on neoadjuvant chemotherapy versus neoadjuvant toripalimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma: Henan Cancer Hospital Thoracic Oncology Group 1909 (HCHTOG1909)
A phase III study on neoadjuvant chemotherapy versus neoadjuvant toripalimab plus chemotherapy for locally advanced esophageal squamous cell carcinoma: Henan Cancer Hospital Thoracic Oncology Group 1909 (HCHTOG1909) Open
NCT04280822 (https://www.clinicaltrials.gov/ct2/show/NCT04280822). Registered title: "A Phase III, Randomized Controlled Study of Neo-adjuvant Toripalimab (JS001) in Combination with Chemotherapy versus Neo-adjuvant Chemotherapy for Resect…
View article: Hand-assisted sputum excretion can effectively reduce postoperative pulmonary complications of esophageal cancer
Hand-assisted sputum excretion can effectively reduce postoperative pulmonary complications of esophageal cancer Open
Our results show that hand-assisted sputum excretion after EC surgery can reduce PPCs.
View article: Effect of Chin‐down‐plus‐larynx‐tightening maneuver on swallowing function after minimally invasive esophagectomy: A randomized controlled trail
Effect of Chin‐down‐plus‐larynx‐tightening maneuver on swallowing function after minimally invasive esophagectomy: A randomized controlled trail Open
Background The incidence of swallowing abnormality was high after minimally invasive esophagectomy (MIE) for esophageal cancer (EC). Few reports, however, focused on interventions for dysphagia after esophagectomy. Aim The purpose of this …
View article: Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a single-Centre, open-label, randomized, controlled, clinical trial (HCHTOG1903)
Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for locally advanced oesophageal squamous cell carcinoma: a single-Centre, open-label, randomized, controlled, clinical trial (HCHTOG1903) Open
View article: Gas permeability in soil amended with biochar at different compaction states
Gas permeability in soil amended with biochar at different compaction states Open
Biochar amended soil (BAS) is widely studied to apply in green infrastructure, such as landfills and slopes. Presence of biochar improved soil hydraulic properties (e.g. water retention ability) in previous studies, while influence of bioc…
View article: Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes
Characterization of 500 Chinese patients with cervical esophageal cancer by clinicopathological and treatment outcomes Open
Objective: There are no comprehensive studies on survival outcomes and optimal treatment protocols for cervical esophageal cancer (CEC), due to its rare clinical prevalence. Our objective was to determine the relationship between pa…
View article: <i>BRCA2</i> loss‐of‐function germline mutations are associated with esophageal squamous cell carcinoma risk in Chinese
<i>BRCA2</i> loss‐of‐function germline mutations are associated with esophageal squamous cell carcinoma risk in Chinese Open
Esophageal squamous cell carcinoma (ESCC) occurs with highest frequency in China with over 90% mortality, highlighting the need for early detection and improved treatment strategies. We aimed to identify ESCC cancer predisposition gene(s).…
View article: Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis
Expression of P-EGFR and P-Akt protein in esophageal squamous cell carcinoma and its prognosis Open
The phosphorylated epidermal growth factor receptor (P-EGFR) and phosphorylated Akt (P-Akt) protein in esophageal squamous cell carcinoma (ESCC) were studied, and its significance in clinical prognosis of patients was assessed. The express…
View article: The BigDAWG polystore system and architecture
The BigDAWG polystore system and architecture Open
Organizations are often faced with the challenge of providing data management\nsolutions for large, heterogenous datasets that may have different underlying\ndata and programming models. For example, a medical dataset may have\nunstructure…