Pei Yi Choo
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View article: Adaptation of <i>Enterococcus faecalis</i> to intestinal mucus revealed by a human colonic organoid model
Adaptation of <i>Enterococcus faecalis</i> to intestinal mucus revealed by a human colonic organoid model Open
The human gastrointestinal tract hosts a diverse population of microorganisms that have a significant impact on host health. Among this population, Enterococcus faecalis ( Ef ) represents a common member of intestinal microbiota colonizing…
View article: Role of sortase-assembled Ebp pili in <i>Enterococcus faecalis</i> adhesion to iron oxides and its impact on extracellular electron transfer
Role of sortase-assembled Ebp pili in <i>Enterococcus faecalis</i> adhesion to iron oxides and its impact on extracellular electron transfer Open
Enterococcus faecalis sortase-assembled endocarditis and biofilm-associated pili (Ebp) are virulence factors implicated in enterococcal biofilm-associated infections and gastrointestinal colonization. We previously showed that E. faecalis …
View article: The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis
The HtrA chaperone monitors sortase-assembled pilus biogenesis in Enterococcus faecalis Open
Sortase-assembled pili contribute to virulence in many Gram-positive bacteria. In Enterococcus faecalis , the endocarditis and biofilm-associated pilus (Ebp) is polymerized on the membrane by sortase C (SrtC) and attached to the cell wall …
View article: An essential protease,<scp>FtsH</scp>, influences daptomycin resistance acquisition in<i>Enterococcus faecalis</i>
An essential protease,<span>FtsH</span>, influences daptomycin resistance acquisition in<i>Enterococcus faecalis</i> Open
Daptomycin is a last‐line antibiotic commonly used to treat vancomycin‐resistant Enterococci, but resistance evolves rapidly and further restricts already limited treatment options. While genetic determinants associated with clinical dapto…
View article: An essential protease, FtsH, influences daptomycin resistance acquisition in<i>Enterococcus faecalis</i>
An essential protease, FtsH, influences daptomycin resistance acquisition in<i>Enterococcus faecalis</i> Open
Summary Daptomycin is a last-line antibiotic commonly used to treat vancomycin resistant Enterococci, but resistance evolves rapidly and further restricts already limited treatment options. While genetic determinants associated with clinic…
View article: Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in <i>Enterococcus faecalis</i>
Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in <i>Enterococcus faecalis</i> Open
Antibiotic resistance critically limits treatment options for infection caused by opportunistic pathogens such as enterococci. Here, we investigate the antibiotic and immunological activity of the anticancer agent mitoxantrone (MTX) in vit…
View article: Spatial and temporal localization of cell wall associated pili in <i>Enterococcus faecalis</i>
Spatial and temporal localization of cell wall associated pili in <i>Enterococcus faecalis</i> Open
Enterococcus faecalis virulence requires cell wall‐associated proteins, including the sortase‐assembled endocarditis and biofilm associated pilus (Ebp), important for biofilm formation in vitro and in vivo. The current paradigm for sortase…
View article: Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in<i>Enterococcus faecalis</i>
Mitoxantrone Targets Both Host and Bacteria to Overcome Vancomycin Resistance in<i>Enterococcus faecalis</i> Open
Among Enterococci, intrinsic and acquired resistance to antibiotics such as β-lactams and vancomycin critically limit treatment options for infection with these opportunistic pathogens. Antimicrobials that enhance the host immune response …
View article: Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition
Escherichia coli BarA-UvrY regulates the pks island and kills Staphylococci via the genotoxin colibactin during interspecies competition Open
Wound infections are often polymicrobial in nature, biofilm associated and therefore tolerant to antibiotic therapy, and associated with delayed healing. Escherichia coli and Staphylococcus aureus are among the most frequently cultured pat…
View article: Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells
Enterococcus faecalis alters endo-lysosomal trafficking to replicate and persist within mammalian cells Open
Enterococcus faecalis is a frequent opportunistic pathogen of wounds, whose infections are associated with biofilm formation, persistence, and recalcitrance toward treatment. We have previously shown that E . faecalis wound infection persi…
View article: <i>Escherichia coli</i> BarA-UvrY regulates the <i>pks</i> island and kills Staphylococci via the genotoxin colibactin
<i>Escherichia coli</i> BarA-UvrY regulates the <i>pks</i> island and kills Staphylococci via the genotoxin colibactin Open
Summary Wound infections are often polymicrobial in nature and are associated with poor disease prognoses. Escherichia coli and Staphylococcus aureus are among the top five most cultured pathogens from wound infections. However, little is …
View article: Spatial and temporal localization of cell wall associated pili in <i>Enterococcus faecalis</i>
Spatial and temporal localization of cell wall associated pili in <i>Enterococcus faecalis</i> Open
Enterococcus faecalis relies upon a number of cell wall-associated proteins for virulence. One virulence factor is the sortase-assembled endocarditis and biofilm associated pilus (Ebp), an important factor for biofilm formation in vitro an…
View article: Enterococcus faecalis Adapts to Antimicrobial Conjugated Oligoelectrolytes by Lipid Rearrangement and Differential Expression of Membrane Stress Response Genes
Enterococcus faecalis Adapts to Antimicrobial Conjugated Oligoelectrolytes by Lipid Rearrangement and Differential Expression of Membrane Stress Response Genes Open
Conjugated oligoelectrolytes (COEs) are emerging antimicrobials with broad spectrum activity against Gram positive and Gram negative bacteria as well as fungi. Our previous in vitro evolution studies using Enterococcus faecalis
View article: Spatial and temporal localization of cell wall associated pili in Enterococcus Faecalis
Spatial and temporal localization of cell wall associated pili in Enterococcus Faecalis Open
Enterococcus faecalis relies upon a number of cell wall-associated proteins for virulence. One sortase-assembled virulence factor is the endocarditis and biofilm associated pilus (Ebp), an important factor for biofilm formation. The curren…
View article: Replication Data for: Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes
Replication Data for: Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes Open
Replication Data for publication: Enterococcus faecalis adapts to antimicrobial conjugated oligoelectrolytes by lipid rearrangement and differential expression of membrane stress response genes. Includes: RNA sequencing data: RAW reads RNA…