Jun Tang
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View article: Bidirectional Mendelian Randomization and Multi-Omics Uncover Causal Serum Metabolites and Neuro-Related Mechanistic Pathways in Acute Myeloid Leukemia
Bidirectional Mendelian Randomization and Multi-Omics Uncover Causal Serum Metabolites and Neuro-Related Mechanistic Pathways in Acute Myeloid Leukemia Open
Acute myeloid leukemia (AML) is a lethal clonal hematopoietic malignancy. Several reports have shown that serum metabolite alterations have been implicated in AML, but the causal relationship and underlying biological mechanisms remain unc…
View article: Identified BIRC5 and HDAC1 as Novel Diagnostic Biomarkers Linked to Centrosome-Immune Crosstalk for Cutaneous Squamous Cell Carcinoma via Machine Learning-Based Multi-omics Analysis
Identified BIRC5 and HDAC1 as Novel Diagnostic Biomarkers Linked to Centrosome-Immune Crosstalk for Cutaneous Squamous Cell Carcinoma via Machine Learning-Based Multi-omics Analysis Open
Background Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer where immune dysregulation plays a critical role in its progression and resistance to therapy. Centrosomal amplification (CA), a marker of genomic instability, con…
View article: Causal relationship between serum metabolites and chronic myeloid leukemia: A bidirectional Mendelian randomization study
Causal relationship between serum metabolites and chronic myeloid leukemia: A bidirectional Mendelian randomization study Open
Previous studies have found a link between serum metabolite levels and chronic myeloid leukemia (CML), yet their exact causal relationship remains unexplored. Using genome-wide association datasets, we conducted bidirectional Mendelian ran…
View article: Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective
Targeting mitochondria with natural polyphenols for treating Neurodegenerative Diseases: a comprehensive scoping review from oxidative stress perspective Open
Neurodegenerative diseases are a class of conditions with widespread detrimental impacts, currently lacking effective therapeutic drugs. Recent studies have identified mitochondrial dysfunction and the resultant oxidative stress as crucial…
View article: Modeling and Analysis in the Industrial Internet with Dual Delay and Nonlinear Infection Rate
Modeling and Analysis in the Industrial Internet with Dual Delay and Nonlinear Infection Rate Open
This study proposes a novel virus propagation model designed explicitly for SCADA(supervisory Control and Data Acquisition) industrial networks. It addresses a critical limitation in existing models applied to the Internet and Industrial I…
View article: Cooling design and optimization of a novel swirl-stabilized trapped vortex combustor with compound-angled effusion cooling configuration
Cooling design and optimization of a novel swirl-stabilized trapped vortex combustor with compound-angled effusion cooling configuration Open
View article: Benefit of standard systemic treatments of solid tumours in Australia varies by indication, tumour stream, and treatment modality
Benefit of standard systemic treatments of solid tumours in Australia varies by indication, tumour stream, and treatment modality Open
View article: Structural Parameter Optimization of Leading-edge Flow Deflector For Application on Wind Turbine.
Structural Parameter Optimization of Leading-edge Flow Deflector For Application on Wind Turbine. Open
The impact of leading-edge flow deflectors on the amount of electricity generated by a wind turbine blade is investigated through numerical simulations. Four structural parameters are considered as design factors in a response surface opti…
View article: VSRDiff: Learning Inter-Frame Temporal Coherence in Diffusion Model for Video Super-Resolution
VSRDiff: Learning Inter-Frame Temporal Coherence in Diffusion Model for Video Super-Resolution Open
Video Super-Resolution (VSR) aims to reconstruct high-quality high-resolution (HR) videos from low-resolution (LR) inputs. Recent studies have explored diffusion models (DMs) for VSR by exploiting their generative priors to produce realist…
View article: Effect of Flow Deflector on the Aerodynamic Performance of the S809 Airfoil
Effect of Flow Deflector on the Aerodynamic Performance of the S809 Airfoil Open
Airfoil stalls at large angles of attack (AoAs), creating flow separation, which directly deteriorates the aerodynamic performance. Numerical simulations were utilized to study a new passive flow control technique for wind turbines. This f…
View article: Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis
Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis Open
Background Despite establishing an association between gut microbiota and spondyloarthritis (SpA) subtypes, the causal relationship between them remains unclear. Methods Gut microbiota data were obtained from the MiBioGen collaboration, an…
View article: Correction: CircPTPN22 modulates T‑cell activation by sponging miR‑4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
Correction: CircPTPN22 modulates T‑cell activation by sponging miR‑4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus Open
View article: Cooling Design and Optimization of a Novel Swirl-Stabilized Trapped Vortex Combustor with Compound-Angled Effusion Cooling Configuration
Cooling Design and Optimization of a Novel Swirl-Stabilized Trapped Vortex Combustor with Compound-Angled Effusion Cooling Configuration Open
View article: Identification of ADAM23 as a Potential Signature for Psoriasis Using Integrative Machine-Learning and Experimental Verification
Identification of ADAM23 as a Potential Signature for Psoriasis Using Integrative Machine-Learning and Experimental Verification Open
ADAM23 may be a potential biomarker in the diagnosis of psoriasis and may contribute to the pathogenesis by regulating immunological activity in psoriatic lesions.
View article: CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus
CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus Open
Background Circular RNAs are involved in autoimmune disease pathogenesis. Our previous study indicated that circPTPN22 is involved in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, but the underly…
View article: HDS screening with patient-derived primary cells guided individualized therapy for esophageal squamous cell carcinoma–in vivo and vitro
HDS screening with patient-derived primary cells guided individualized therapy for esophageal squamous cell carcinoma–in vivo and vitro Open
Objective To analyze and evaluate the role of the High-throughput Drug Sensitivity (HDS) screening strategy in identifying highly sensitive drugs against esophageal squamous cell carcinoma (ESCC). Methods A total of 80 patients with progre…
View article: Experimental study of coal flow characteristics under mining disturbance in China
Experimental study of coal flow characteristics under mining disturbance in China Open
With annually increased coal mining depth, gas extraction becomes more and more problematic. The gas extraction effect depends on coal seam permeability, which, in turn, is affected by many factors, including loading and unloading stresses…
View article: Stitching Repair for Delaminated Carbon Fiber/Bismaleimide Composite Laminates
Stitching Repair for Delaminated Carbon Fiber/Bismaleimide Composite Laminates Open
Due to the excellent mechanical properties and heat resistance, bismaleimide matrix composite materials have been widely used in aircraft. However, they are susceptible to low-energy impacts, such as bird hits, gravel, tools falling, etc.,…
View article: Research on Buffer Characteristics of a New 2D Digital Buffer Valve for Vehicle Shift
Research on Buffer Characteristics of a New 2D Digital Buffer Valve for Vehicle Shift Open
The clutch is currently developing towards high power, high stability, and intelligent operation. The traditional hydraulic buffering valve mostly uses a passive hydraulic buffer valve or a high speed on-off valve and a proportion valve. I…
View article: A Method of Two-Stage Pressure Control Based on Multistage Orifices
A Method of Two-Stage Pressure Control Based on Multistage Orifices Open
The interaction of pressure and flow in a hydraulic system with multiple working conditions, multiple actuators, and large flow limits action adjustment and control. Through a pilot pressure control circuit, hydraulically operated valves c…
View article: [Differential diagnosis of high altitude pulmonary edema and COVID-19 with computed tomography feature].
[Differential diagnosis of high altitude pulmonary edema and COVID-19 with computed tomography feature]. Open
To investigate the computed tomography (CT) characteristics and differential diagnosis of high altitude pulmonary edema (HAPE) and COVID-19, CT findings of 52 cases of HAPE confirmed in Medical Station of Sanshili Barracks, PLA 950 Hospita…
View article: Optimization and verification of wind tunnel free-flight similarity law for separation of cluster munition
Optimization and verification of wind tunnel free-flight similarity law for separation of cluster munition Open
In view of the separation form of the separator from the back of the carrier upward and from the side of the carrier outward, separation-safety research is carried out by taking the separation of a cluster munition as an example. In previo…
View article: CCDC 1892122: Experimental Crystal Structure Determination
CCDC 1892122: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Modeling of Sandia Piloted Flame D and F using Flamelet-Generated Manifolds
Modeling of Sandia Piloted Flame D and F using Flamelet-Generated Manifolds Open
For purpose of studying the application of Flamelet Generated Manifolds (FGM) model in numerical simulation of combustion, the combustion field of Sandia piloted flame D and F were studied using FGM model.The laminar flamelet database was …
View article: Fluidization characteristics of different sizes of quartz particles in the fluidized bed
Fluidization characteristics of different sizes of quartz particles in the fluidized bed Open
Fluidization characteristics of quartz particles with different sizes are experimentally investigated in a fluidized bed with an inner diameter of 300 mm and height of 8250 mm. Results show that the average solid holdup increases with the …