Pei‐Hsuan Lin
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View article: Environmental Institutional Determinants of Climate Behavior Among Taiwan’s Public Officials
Environmental Institutional Determinants of Climate Behavior Among Taiwan’s Public Officials Open
This study investigates how climate change literacy (CCL) and institutional contexts shape the climate-related behaviors of Taiwan’s public officials. Drawing on a 2024 national survey of 1940 civil servants, we apply hierarchical and comp…
View article: Novel <i>Grm6</i> Variant in a <i>no b-wave (nob)</i> Mouse Model: Phenotype Characterization and Gene Therapy
Novel <i>Grm6</i> Variant in a <i>no b-wave (nob)</i> Mouse Model: Phenotype Characterization and Gene Therapy Open
We identified a new nob mouse model that mimics the CSNB phenotype in human patients. Whereas gene therapy successfully restored mGluR6 expression, functional improvements were limited. Early treatment using a specific promoter is critical…
View article: Environmental Institutional Determinants of Climate Behavior in Taiwan's Public Officials
Environmental Institutional Determinants of Climate Behavior in Taiwan's Public Officials Open
This study investigates how climate change literacy (CCL) and institutional contexts shape the climate-related behaviors of Taiwan’s public officials. Drawing on a 2024 national survey of 1,940 civil servants, we apply hierarchical and com…
View article: Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling
Reprogramming the aging ovarian microenvironment via mitochondrial sharing and structural remodeling Open
Rationale: Mitochondrial dysfunction in ovarian granulosa cells (GCs) and cumulus cells (CCs) is a defining feature of reproductive aging, contributing to impaired oocyte quality and reduced fertility. This study investigates whethe…
View article: Enhancing embryo quality through meiotic spindle-aligned microinjection in POSEIDON group 4 patients undergoing IVF-ICSI cycles: A retrospective cohort study
Enhancing embryo quality through meiotic spindle-aligned microinjection in POSEIDON group 4 patients undergoing IVF-ICSI cycles: A retrospective cohort study Open
MS-aligned microinjection may enhance embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles.
View article: Waardenburg Syndrome Type 4 in Mongolian Children: Genetic and Clinical Characterization
Waardenburg Syndrome Type 4 in Mongolian Children: Genetic and Clinical Characterization Open
Waardenburg syndrome (WS) is a rare genetic disorder that affects both hearing and pigmentation. The wide divergence of WS poses significant diagnostic and management challenges. This study investigated type 4 WS within an underrepresented…
View article: Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of the SLC26A4 c.919-2A>G Variant
Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of the SLC26A4 c.919-2A>G Variant Open
Recessive variants of SLC26A4 are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic SLC26A4 variants often suffer from fluctua…
View article: Unraveling the complex genetic landscape of OTOF-related hearing loss: a deep dive into cryptic variants and haplotype phasing
Unraveling the complex genetic landscape of OTOF-related hearing loss: a deep dive into cryptic variants and haplotype phasing Open
Background Pathogenic variants in OTOF are a major cause of auditory synaptopathy. However, challenges remain in interpreting OTOF variants, including difficulties in confirming haplotype phasing using traditional short-read sequencing (SR…
View article: 2FA-Platform Generates Dual Fatty Acid-Conjugated GLP-1 Receptor Agonist TE-8105 with Enhanced Diabetes, Obesity, and NASH Efficacy Compared to Semaglutide
2FA-Platform Generates Dual Fatty Acid-Conjugated GLP-1 Receptor Agonist TE-8105 with Enhanced Diabetes, Obesity, and NASH Efficacy Compared to Semaglutide Open
Conjugating two fatty acids (2FAs) to peptide drugs can improve pharmacokinetics and therapeutic effects. However, optimizing FA spacing, chain combination, and attachment site to simultaneously enhance albumin binding and drug efficacy re…
View article: Predominance of Auditory But Not Vestibular Deficits in a Mouse Model of Congenital Cytomegalovirus Infection
Predominance of Auditory But Not Vestibular Deficits in a Mouse Model of Congenital Cytomegalovirus Infection Open
Objectives. The aim of this study was to investigate the auditory and vestibular consequences of congenital cytomegalovirus (cCMV) infection in a C57BL/6 mouse model. This model, established via intraperitoneal inoculation, was designed to…
View article: Screening for Hearing Impairment in Newborns Using Targeted Genomic Sequencing: A Large Pilot Cohort Study
Screening for Hearing Impairment in Newborns Using Targeted Genomic Sequencing: A Large Pilot Cohort Study Open
Objectives. State-run newborn hearing screening (NBHS) programs have limitations in identifying children with mild or late-onset sensorineural hearing impairment (SNHI). Given that over 50% of pediatric SNHI cases are linked to genetic cau…
View article: Comprehensive genetic analysis of<i>STRC</i>variants in hereditary hearing impairment using long-read sequencing
Comprehensive genetic analysis of<i>STRC</i>variants in hereditary hearing impairment using long-read sequencing Open
Background: Sensorineural hearing impairment (SNHI) is a common disorder with a significant genetic component. Genetic testing for SNHI often involves next-generation sequencing (NGS), but SNHI-related pathogenic STRC variants cannot be di…
View article: Correction: Cuproptosis-Related Gene FDX1 Identified as a Potential Target for Human Ovarian Aging
Correction: Cuproptosis-Related Gene FDX1 Identified as a Potential Target for Human Ovarian Aging Open
View article: Genetic Basis of Hearing Loss in Mongolian Patients: A Next-Generation Sequencing Study
Genetic Basis of Hearing Loss in Mongolian Patients: A Next-Generation Sequencing Study Open
Background/Objective: The genetic landscape of sensorineural hearing impairment (SNHI) varies across populations. In Mongolia, previous studies have shown a lower prevalence of GJB2 mutations and a higher frequency of variants in other dea…
View article: Mitochondria in Retinal Ganglion Cells: Unraveling the Metabolic Nexus and Oxidative Stress
Mitochondria in Retinal Ganglion Cells: Unraveling the Metabolic Nexus and Oxidative Stress Open
This review explored the role of mitochondria in retinal ganglion cells (RGCs), which are essential for visual processing. Mitochondrial dysfunction is a key factor in the pathogenesis of various vision-related disorders, including glaucom…
View article: Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study
Improvement of early miscarriage rates in women with adenomyosis via oxytocin receptor antagonist during frozen embryo transfer-a propensity score-matched study Open
View article: A GUCY2D variant associated cone-rod dystrophy with electronegative ERG: A case report and review
A GUCY2D variant associated cone-rod dystrophy with electronegative ERG: A case report and review Open
We report two different clinical phenotypes in GUCY2D-associated COD despite sharing the same variant. A dysfunction in the synaptic junction between the photoreceptor and the secondary neuron was proposed to explain the electronega…
View article: Enhancing Education on Aurora Astronomy and Climate Science Awareness through Augmented Reality Technology and Mobile Learning
Enhancing Education on Aurora Astronomy and Climate Science Awareness through Augmented Reality Technology and Mobile Learning Open
In our contemporary digital age, the profound integration of the internet, mobile devices, and innovative educational technologies has revolutionized the landscape of digital education. This transformation has unfolded a world of possibili…
View article: Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of SLC26A4 c.919–2A&gt;G Variant
Low Efficiency of Homology-Independent Targeted Integration for CRISPR/Cas9 Correction in the Vicinity of SLC26A4 c.919–2A>G Variant Open
Recessive variants of SLC26A4 are a common cause of hereditary hearing impairment and are responsible for non-syndromic enlarged vestibular aqueducts and Pendred syndrome. Patients with bi-allelic SLC26A4 variants often suffer from fluctua…
View article: Correction: Unraveling the Clinical Relevance of Ferroptosis-Related Genes in Human Ovarian Aging
Correction: Unraveling the Clinical Relevance of Ferroptosis-Related Genes in Human Ovarian Aging Open
View article: Intravascular Laser Blood Irradiation (ILIB) Enhances Antioxidant Activity and Energy Metabolism in Aging Ovaries
Intravascular Laser Blood Irradiation (ILIB) Enhances Antioxidant Activity and Energy Metabolism in Aging Ovaries Open
Background: Ovarian aging is characterized by the accumulation of free radicals, leading to tissue damage and affecting reproductive health. Intravascular laser irradiation of blood (ILIB, using a low-energy He-Ne laser) is known for its e…
View article: Genetic underpinnings explored: OPA1 deletion and complex phenotypes on chromosome 3q29
Genetic underpinnings explored: OPA1 deletion and complex phenotypes on chromosome 3q29 Open
View article: An Antibody‐Drug Conjugate for Multiple Myeloma Prepared by Multi‐Arm Linkers
An Antibody‐Drug Conjugate for Multiple Myeloma Prepared by Multi‐Arm Linkers Open
First‐line treatment of multiple myeloma, a prevalent blood cancer lacking a cure, using anti‐CD38 daratumumab antibody and lenalidomide is often inadequate due to relapse and severe side effects. To enhance drug safety and efficacy, an an…
View article: Design a Data Analytics Training System to Explore Behavioral Intention and Immersion for Internal Enterprise Education
Design a Data Analytics Training System to Explore Behavioral Intention and Immersion for Internal Enterprise Education Open
This research delves into the integration of the CDIO framework and gamified learning into a web crawling system, aiming to elevate the innovation and practical skills of corporate trainees. The study examines the effects on learning achie…
View article: Simplified segmental scleral buckling without localization and cryopexy: A retrospective comparison with conventional segmental scleral buckling
Simplified segmental scleral buckling without localization and cryopexy: A retrospective comparison with conventional segmental scleral buckling Open
PURPOSE: The aim of this study was to propose a simplified segmental scleral buckling (SSSB) technique that does not require break localization for less-experienced vitreoretinal surgeons. MATERIALS AND METHODS: This retrospective study co…
View article: Administration of Oxytocin Receptor Antagonist during Frozen Embryo Transfer: Potential Improvement in Live Birth Rates for Women with Recurrent Implantation Failure, Adenomyosis, and Myoma
Administration of Oxytocin Receptor Antagonist during Frozen Embryo Transfer: Potential Improvement in Live Birth Rates for Women with Recurrent Implantation Failure, Adenomyosis, and Myoma Open
Background The primary objective of this investigation was to assess the potential improvement in pregnancy outcomes among infertile women undergoing in vitro fertilization (IVF) cycles, specifically during frozen embryo transfer (FET), fo…
View article: Enhancing Embryo Quality through Meiotic Spindle- Aligned Microinjection in POSEIDON Group 4 Patients Undergoing ICSI Cycles: A Retrospective Cohort Study
Enhancing Embryo Quality through Meiotic Spindle- Aligned Microinjection in POSEIDON Group 4 Patients Undergoing ICSI Cycles: A Retrospective Cohort Study Open
Background Embryologists have traditionally depended on the polar body (PB) as a reference point for guiding the process of intracytoplasmic sperm injection (ICSI). However, its accuracy in predicting the precise location of the meiotic sp…
View article: A Novel Method for Audiogram Digitization in Audiological Reports
A Novel Method for Audiogram Digitization in Audiological Reports Open
An audiogram records the hearing status, including each hearing threshold at multiple frequencies. While deep learning is gradually maturing in the clinical research approach, audiologists could speed up their diagnostic process with audio…
View article: Clinical Characteristics and Genetic Variants in Taiwanese Patients With <i>PROM1</i>-Related Inherited Retinal Disorders
Clinical Characteristics and Genetic Variants in Taiwanese Patients With <i>PROM1</i>-Related Inherited Retinal Disorders Open
In this study, we evaluated 14 Taiwanese patients with five PROM1 variants. Additionally, incomplete penetrance of heterozygous PROM1 variants was observed. Furthermore, patients with autosomal dominant PROM1 variants had lesions in the ma…
View article: The Value of Electroretinography in Identifying Candidate Genes for Inherited Retinal Dystrophies: A Diagnostic Guide
The Value of Electroretinography in Identifying Candidate Genes for Inherited Retinal Dystrophies: A Diagnostic Guide Open
Inherited retinal dystrophies (IRDs) are a group of heterogeneous diseases caused by genetic mutations that specifically affect the function of the rod, cone, or bipolar cells in the retina. Electroretinography (ERG) is a diagnostic tool t…