Peiyu Huang
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View article: Dapagliflozin reduces proteinuria in IgA nephropathy patients receiving immunosuppressive therapy
Dapagliflozin reduces proteinuria in IgA nephropathy patients receiving immunosuppressive therapy Open
Sodium-glucose cotransporter 2 inhibitors reduced proteinuria in patients with IgA nephropathy; however, their efficacy in patients at high risk of progression receiving immunosuppressive agents and renin angiotensin-aldosterone system inh…
View article: Delayed Viral Clearance Accompanied by Early Impaired Humoral and Virus-Specific T-Cell Response in Patients with Coronavirus Disease 2019 and Interstitial Lung Disease
Delayed Viral Clearance Accompanied by Early Impaired Humoral and Virus-Specific T-Cell Response in Patients with Coronavirus Disease 2019 and Interstitial Lung Disease Open
Objectives: Patients with interstitial lung disease (ILD) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are at high risk of severe coronavirus disease 2019. It is unclear whether anti-viral cellular and humoral…
View article: Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China
Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China Open
View article: Best Practices for Chronic Pancreatitis Pain Management: A Comprehensive Evidence-Based Review
Best Practices for Chronic Pancreatitis Pain Management: A Comprehensive Evidence-Based Review Open
This review consolidates the best available evidence for pain management in CP. However, in clinical application, the optimal intervention should be individualized, taking into account patient preferences, the healthcare institution's tech…
View article: Identifying factors contributing to kinesiophobia in patients post-percutaneous coronary intervention
Identifying factors contributing to kinesiophobia in patients post-percutaneous coronary intervention Open
Not applicable.
View article: Effect of wild-type vaccine doses on BA.5 hybrid immunity, disease severity, and XBB reinfection risk
Effect of wild-type vaccine doses on BA.5 hybrid immunity, disease severity, and XBB reinfection risk Open
Vaccination against the wild-type (WT) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus did not produce detectable levels of neutralizing antibodies (NAbs) against the BA.5 strain before it emerged. However, coronavirus d…
View article: Novel imported clades accelerated the RSV surge in Beijing, China, 2023-2024
Novel imported clades accelerated the RSV surge in Beijing, China, 2023-2024 Open
The novel imported clade B.D.E.1 accelerated an unprecedented RSV surge in Beijing, presenting noteworthy epidemiological and biological characteristics. Continuous RSV genome monitoring has important implications for RSV outbreak identifi…
View article: Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate COPD: a double-blind, parallel group, multicentre randomised clinical trial Open
View article: Summary of Best Evidence to Address Kinesiophobia Post Percutaneous Coronary Intervention: An Evidence-Based Review
Summary of Best Evidence to Address Kinesiophobia Post Percutaneous Coronary Intervention: An Evidence-Based Review Open
In clinical settings, using evidence-based practices requires developing feasible intervention programs based on comprehensive consideration of hospital resources, allocation of medical personnel, and consideration of patients' preferences…
View article: Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China
Clinical features and associated factors of impaired ventilatory efficiency: findings from the ECOPD study in China Open
Background Impaired ventilatory efficiency during exercise is a predictor of mortality in chronic obstructive pulmonary disease. However, little is known about the clinical features and associated factors of impaired ventilatory efficiency…
View article: Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection
Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection Open
The immunoprotective components control COVID-19 disease severity, as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity, remain unclarified. Here, we longitudinal…
View article: Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate chronic obstructive pulmonary disease: a multicentre, double-blind, randomised, placebo-controlled trial
Effect of high-dose N-acetylcysteine on exacerbations and lung function in patients with mild-to-moderate chronic obstructive pulmonary disease: a multicentre, double-blind, randomised, placebo-controlled trial Open
Evidence for the treatment of patients with mild-to-moderate chronic obstructive pulmonary disease (COPD) is limited. The efficacy of N-acetylcysteine (an antioxidant and mucolytic agent) for patients with mild-to-moderate COPD is uncertai…
View article: Construction and Validation of Active Case-Finding Models in Community Participants with Chronic Obstructive Pulmonary Disease Using an Interpretable Machine Learning Approach: A Study Based on Guangdong Population
Construction and Validation of Active Case-Finding Models in Community Participants with Chronic Obstructive Pulmonary Disease Using an Interpretable Machine Learning Approach: A Study Based on Guangdong Population Open
View article: Clinical features and 1-year outcomes of chronic bronchitis in participants with normal spirometry: results from the ECOPD study in China
Clinical features and 1-year outcomes of chronic bronchitis in participants with normal spirometry: results from the ECOPD study in China Open
Background Evidence regarding clinical features and outcomes of individuals with non-obstructive chronic bronchitis (NOCB) remains scarce, especially in never-smokers. We aimed to investigate the clinical features and 1-year outcomes of in…
View article: Impaired exercise capacity in individuals with non-obstructive small airway dysfunction
Impaired exercise capacity in individuals with non-obstructive small airway dysfunction Open
Although not meeting the current criteria for chronic obstructive pulmonary disease, individuals with non-obstructive SAD have impaired exercise capacity that may be associated with ventilatory inefficiency regardless of smoking status.
View article: SARS-CoV-2 vaccination-infection pattern imprints and diversifies T cell differentiation and neutralizing response against Omicron subvariants
SARS-CoV-2 vaccination-infection pattern imprints and diversifies T cell differentiation and neutralizing response against Omicron subvariants Open
View article: Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity
Preserved ratio impaired spirometry is associated with small airway dysfunction and reduced total lung capacity Open
Background: Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV 1 ) in the setting of preserved ratio. Little is known about the role of PRISm and its complex relation with small airway dysf…
View article: The association between small airway dysfunction and aging: a cross-sectional analysis from the ECOPD cohort
The association between small airway dysfunction and aging: a cross-sectional analysis from the ECOPD cohort Open
View article: Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study
Association Between Serum Total Bilirubin Level and Lung Function Decline in Patients with COPD: Results from a Pooled Study Open
Increased TB level was related to less annual decline in FEV1 as well as FEV1pred in moderate-to-severe COPD but not mild COPD, which indicated the different status of TB in different COPD severity and the possible ro…
View article: Validity of a portable spirometer in the communities of China
Validity of a portable spirometer in the communities of China Open
View article: Predictors of High Sputum Eosinophils in COPD
Predictors of High Sputum Eosinophils in COPD Open
High blood eosinophil levels, severe respiratory symptoms, being a former smoker, and a family history of respiratory diseases may be predictors of high sputum eosinophil levels in Chinese COPD patients. High sputum eosinophils were associ…
View article: Rationale and design of the Early Chronic Obstructive Pulmonary Disease (ECOPD) study in Guangdong, China: a prospective observational cohort study
Rationale and design of the Early Chronic Obstructive Pulmonary Disease (ECOPD) study in Guangdong, China: a prospective observational cohort study Open
Chinese Clinical Trial Registry, ChiCTR1900024643. Registered on 19 July, 2019.
View article: Validity of a Portable Spirometer in the Communities of China
Validity of a Portable Spirometer in the Communities of China Open
Background : The lack of simple and affordable spirometry has led to the missed and delayed diagnoses of chronic respiratory diseases in communities. The PUS201P is a portable spirometry developed to solve this problem. Objective: We aimed…
View article: Long noncoding RNA IL6‐AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR‐149‐5p and early B‐cell factor 1
Long noncoding RNA IL6‐AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR‐149‐5p and early B‐cell factor 1 Open
Chronic obstructive pulmonary disease is a complex condition with multiple etiologies, including inflammation. We identified a novel long noncoding RNA (lncRNA), interleukin 6 antisense RNA 1 (IL6‐AS1), which is upregulated in this disease…
View article: High-dose N-acetylcysteine for long-term, regular treatment of early-stage chronic obstructive pulmonary disease (GOLD I–II): study protocol for a multicenter, double-blinded, parallel-group, randomized controlled trial in China
High-dose N-acetylcysteine for long-term, regular treatment of early-stage chronic obstructive pulmonary disease (GOLD I–II): study protocol for a multicenter, double-blinded, parallel-group, randomized controlled trial in China Open
View article: The forensic landscape and the population genetic analyses of Hainan Li based on massively parallel sequencing DNA profiling
The forensic landscape and the population genetic analyses of Hainan Li based on massively parallel sequencing DNA profiling Open
Due to the formation of the Qiongzhou Strait by climate change and marine transition, Hainan island isolated from the mainland southern China during the Last Glacial Maximum. Hainan island, located at the southernmost part of China and sep…
View article: Pre-extubation functional residual capacity and risk of extubation failure among patients with hypoxemic respiratory failure
Pre-extubation functional residual capacity and risk of extubation failure among patients with hypoxemic respiratory failure Open
View article: Age- and Gender-Specific Disease Burden Under Taiwan's National Health Insurance System
Age- and Gender-Specific Disease Burden Under Taiwan's National Health Insurance System Open
View article: Examination of HIV Risk and the HIV/AIDS Epidemic in the U.S. Virgin Islands
Examination of HIV Risk and the HIV/AIDS Epidemic in the U.S. Virgin Islands Open
Objective: The U.S. Virgin Islands (USVI) currently has the 3 rd highest per capita rate of HIV in the United States.The purpose of this descriptive study was to examine the risk factors that contribute to high rates of HIV in the USVI.Met…