Ping Xu
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View article: Integrating transcriptomics with metabolomics reveals the differential mechanisms underlying the color and volatile substances of Amomum tsao-ko
Integrating transcriptomics with metabolomics reveals the differential mechanisms underlying the color and volatile substances of Amomum tsao-ko Open
Amomum tsao-ko is a significant medicinal and edible plant, recognized for its distinctive aroma. The pericarp color varies among different cultivars, yet the relationship between pericarp color and both edible and medicinal values, as wel…
View article: Two-Dimensional GC–ToFMS Analysis of Volatile Organic Compounds in Fermented Camel Milk (Shubat)
Two-Dimensional GC–ToFMS Analysis of Volatile Organic Compounds in Fermented Camel Milk (Shubat) Open
Shubat, a traditional fermented camel milk from Kazakhstan, is renowned for its unique flavor and nutritional properties, though its volatile compound profile remains poorly characterized. In this study, headspace solid-phase microextracti…
View article: A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate
A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate Open
Glutarate is a platform chemical with diversified applications. It is also an endogenous metabolite involved in various physiological processes. Deficiency in glutaryl‐CoA dehydrogenase (GcdH) for glutarate catabolism induces the inherited…
View article: Dual regulatory role of cyclic di-GMP via the DgcY/HhmR complex in salt response of <i>Halomonas hydrothermalis</i> Y2
Dual regulatory role of cyclic di-GMP via the DgcY/HhmR complex in salt response of <i>Halomonas hydrothermalis</i> Y2 Open
Bis-(3′−5′)-cyclic dimeric guanosine monophosphate (c-di-GMP) is a key second messenger synthesized by diguanylate cyclases (DGCs) and regulates diverse bacterial behaviors. While many DGC modules are integrated within complex regulatory c…
View article: A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate
A genetically encoded biosensor for point-of-care and live-cell detection of d-2-hydroxyglutarate Open
View article: Nitrogen, phosphorus and potassium formula fertilization model of Lonicera japonica Thunb in hilly and gully Loess Plateau of China
Nitrogen, phosphorus and potassium formula fertilization model of Lonicera japonica Thunb in hilly and gully Loess Plateau of China Open
Formula fertilization has been shown to effectively increase both yield and economic profit in medicinal plants. Lonicera japonica Thunb (L. japonica) is a significant medicinal plant; however, no studies have yet investigated the impact o…
View article: Production of dicarboxylates from ω-amino acids using a cofactor- and co-substrate-free in vitro biosynthetic system
Production of dicarboxylates from ω-amino acids using a cofactor- and co-substrate-free in vitro biosynthetic system Open
Dicarboxylates are valuable platform compounds with a broad range of applications. The in vitro biosynthetic system used to produce dicarboxylates from ω-amino acids via the natural pathway requires costly cofactors and co-substrates, whic…
View article: Current diagnosing strategies for <i>Mycobacterium tuberculosis</i> and its drug resistance: a review
Current diagnosing strategies for <i>Mycobacterium tuberculosis</i> and its drug resistance: a review Open
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major global health threat, compounded by the rise of extensively drug-resistant (XDR) and multidrug-resistant (MDR) strains. This review critically examines the curr…
View article: Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs
Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs Open
MicroRNAs (miRNAs) are crucial in regulating cardiac aging and related diseases, yet few functional miRNAs have been identified. Prior studies showed miR-216a upregulation in heart failure patients, but its impact on aging hearts is unknow…
View article: Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs
Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in Drosophila Resulting from miR-283 Knockdown in LNvs Open
MicroRNAs (miRNAs) are crucial in regulating cardiac aging and related diseases, yet few functional miRNAs have been identified. Prior studies showed miR-216a upregulation in heart failure patients, but its impact on aging hearts is unknow…
View article: Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in <i>Drosophila</i> Resulting from miR-283 Knockdown in LN <sub>v</sub> s
Endurance Exercise Ameliorates Aging-Related Bradyarrhythmia in <i>Drosophila</i> Resulting from miR-283 Knockdown in LN <sub>v</sub> s Open
MicroRNAs (miRNAs) are crucial in regulating cardiac aging and related diseases, yet few functional miRNAs have been identified. Prior studies showed miR-216a upregulation in heart failure patients, but its impact on aging hearts is unknow…
View article: Dissection of transcriptome and metabolome insights into the polyphyllin biosynthesis in Paris
Dissection of transcriptome and metabolome insights into the polyphyllin biosynthesis in Paris Open
View article: Many birds with one stone: When bioremediation meets synthetic biology
Many birds with one stone: When bioremediation meets synthetic biology Open
View article: Consensus Summary on the Clinical Application of Patient-Controlled Analgesia for Pain Management in China
Consensus Summary on the Clinical Application of Patient-Controlled Analgesia for Pain Management in China Open
View article: Mapping functional elements of the DNA damage response through base editor screens
Mapping functional elements of the DNA damage response through base editor screens Open
Maintaining genomic stability is vital for cellular equilibrium. In this study, we combined CRISPR-mediated base editing with pooled screening technologies to identify numerous mutations in lysine residues and protein-coding genes. The los…
View article: Metabolomics and transcriptomics profiling of three Paris species with varied polyphyllin compositions
Metabolomics and transcriptomics profiling of three Paris species with varied polyphyllin compositions Open
Most of the species in Paris have important medicinal values in China. Polyphyllins are the key components in Paris, with varying levels and compositions among different species. This study investigated polyphyllin compositions of 206 Pari…
View article: Metagenomic analysis reveals houseflies as indicators for monitoring environmental antibiotic resistance genes
Metagenomic analysis reveals houseflies as indicators for monitoring environmental antibiotic resistance genes Open
Given the threat to public health posed by antibiotic resistance transmission, environmental monitoring is essential for tracking antibiotic resistance genes (ARGs). Houseflies, being ubiquitous organisms capable of carrying and disseminat…
View article: Lacticaseibacillus rhamnosus LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial
Lacticaseibacillus rhamnosus LRa05 in the treatment of acute diarrhea in children: a randomized controlled trial Open
Introduction The goal of this study is to assess the efficacy and safety of Lacticaseibacillus rhamnosus LRa05, as an adjunct to the treatment of acute watery diarrhea in children. Methods Eligible diarrheal children were randomized into i…
View article: Acetate production from corn stover hydrolysate using recombinant Escherichia coli BL21 (DE3) with an EP-bifido pathway
Acetate production from corn stover hydrolysate using recombinant Escherichia coli BL21 (DE3) with an EP-bifido pathway Open
View article: GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model
GeneCompass: deciphering universal gene regulatory mechanisms with a knowledge-informed cross-species foundation model Open
Deciphering universal gene regulatory mechanisms in diverse organisms holds great potential for advancing our knowledge of fundamental life processes and facilitating clinical applications. However, the traditional research paradigm primar…
View article: Production of α-ketoisovalerate with whey powder by systemic metabolic engineering of Klebsiella oxytoca
Production of α-ketoisovalerate with whey powder by systemic metabolic engineering of Klebsiella oxytoca Open
View article: Rational design of a flavoenzyme for aerobic nicotine catabolism
Rational design of a flavoenzyme for aerobic nicotine catabolism Open
Enzymatic therapy with nicotine-degrading enzyme is a new strategy in treating nicotine addiction, which can reduce nicotine concentrations and weaken withdrawal in the rat model. However, when O 2 is used as the electron acceptor, no sati…
View article: Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target
Pan-cancer analyses reveal the molecular and clinical characteristics of TET family members and suggests that TET3 maybe a potential therapeutic target Open
The Ten-Eleven Translocation (TET) family genes are implicated in a wide array of biological functions across various human cancers. Nonetheless, there is a scarcity of studies that comprehensively analyze the correlation between TET famil…
View article: An Ultrasensitive Biosensor for Probing Subcellular Distribution and Mitochondrial Transport of <scp>l</scp>‐2‐Hydroxyglutarate
An Ultrasensitive Biosensor for Probing Subcellular Distribution and Mitochondrial Transport of <span>l</span>‐2‐Hydroxyglutarate Open
l ‐2‐Hydroxyglutarate ( l ‐2‐HG) is a functionally compartmentalized metabolite involved in various physiological processes. However, its subcellular distribution and mitochondrial transport remain unclear owing to technical limitations. I…
View article: Rational Design of a Flavoenzyme for Aerobic Nicotine Catabolism
Rational Design of a Flavoenzyme for Aerobic Nicotine Catabolism Open
Enzymatic therapy with nicotine-degrading enzyme is a new strategy in treating nicotine addiction, which can reduce nicotine concentrations and weaken withdrawal in the rat model. However, when O 2 is used as the electron acceptor, no sati…
View article: Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code
Design of a water-soluble transmembrane receptor kinase with intact molecular function by QTY code Open
Membrane proteins are critical to biological processes and central to life sciences and modern medicine. However, membrane proteins are notoriously challenging to study, mainly owing to difficulties dictated by their highly hydrophobic nat…
View article: Development of an “on-off-on” fluoroprobe utilizing an anthrylimidazole-based fluorescent ionic liquid for sensitive Cr(VI) and ascorbic acid detection
Development of an “on-off-on” fluoroprobe utilizing an anthrylimidazole-based fluorescent ionic liquid for sensitive Cr(VI) and ascorbic acid detection Open
Developing a rapid detection method of Cr(VI) and ascorbic acid (AA) is vital in the food and environmental fields. Herein, an anthrylimidazole-based fluorescent ionic liquid (AI-FIL) with the advantageous fluorescent properties was succes…
View article: Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice
Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice Open
Introduction Black tea, a beverage consumed worldwide, possesses favorable effects on gastrointestinal tract, including nourishing stomach and promoting digestion. Nevertheless, its specific effects on intestinal homeostasis remains inconc…
View article: Explore the gene regulation mechanism under high temperature and hypoxia stress in the sea cucumber Apostichopus japonicus by high-throughput RNA-seq technology
Explore the gene regulation mechanism under high temperature and hypoxia stress in the sea cucumber Apostichopus japonicus by high-throughput RNA-seq technology Open
Temperature and dissolved oxygen (DO) are important biological environmental factors for aquatic animal. The sea cucumber Apostichopus japonicus was an important aquaculture species in China, which was highly impacted by temperature and DO…
View article: Fine-tuning an aromatic ring-hydroxylating oxygenase to degrade high molecular weight polycyclic aromatic hydrocarbon
Fine-tuning an aromatic ring-hydroxylating oxygenase to degrade high molecular weight polycyclic aromatic hydrocarbon Open
Rieske nonheme iron aromatic ring-hydroxylating oxygenases (RHOs) play pivotal roles in determining the substrate preferences of polycyclic aromatic hydrocarbon (PAH) degraders. However, their potential to degrade high molecular weight PAH…