Peijing Yan
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View article: Physical activity during adolescence protects against depression in adulthood: a systematic review and meta-analysis (Preprint)
Physical activity during adolescence protects against depression in adulthood: a systematic review and meta-analysis (Preprint) Open
BACKGROUND Growing evidence indicates physical activity (PA) in early life appear to influence depression development in later life. However, questions remain regarding whether PA during adolescence, a critical early-life period, has a lo…
View article: Adult Height, Cardiovascular Disease, and the Underlying Mechanism: A Comprehensive Epidemiological and Genetic Analysis
Adult Height, Cardiovascular Disease, and the Underlying Mechanism: A Comprehensive Epidemiological and Genetic Analysis Open
Our study confirms the health effects of height on CAD, atrial fibrillation, and venous thromboembolism and emphasizes forced vital capacity as the primary pathway that links height to CAD. Importantly, it indicates that the CAD risk assoc…
View article: The reporting quality and methodological quality of dynamic prediction models for cancer prognosis
The reporting quality and methodological quality of dynamic prediction models for cancer prognosis Open
The Landmark model and joint model show potential in DPM. The suboptimal reporting and methodological qualities of current DPM studies should be improved to facilitate clinical application.
View article: Physical activity and risk of depression in adolescents: A systematic review and meta-analysis of prospective observational studies
Physical activity and risk of depression in adolescents: A systematic review and meta-analysis of prospective observational studies Open
Our systematic review and meta-analysis of prospective observational studies indicates that higher levels of PA are associated with a reduced risk of depression in adolescents. This highlights the need for policies to promote increased PA …
View article: Exercise, weight maintenance, and nonalcoholic fatty liver disease risk: a Chinese cohort study
Exercise, weight maintenance, and nonalcoholic fatty liver disease risk: a Chinese cohort study Open
Background: Exercise has been reported to be associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD), but there is no consensus on the role of weight changes in this association. This study aims to investigate whether th…
View article: Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses
Risk factors for prostate cancer: An umbrella review of prospective observational studies and mendelian randomization analyses Open
Background The incidence of prostate cancer is increasing in older males globally. Age, ethnicity, and family history are identified as the well-known risk factors for prostate cancer, but few modifiable factors have been firmly establishe…
View article: Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses
Independent association of general and central adiposity with risk of gallstone disease: observational and genetic analyses Open
Background General obesity is a well-established risk factor for gallstone disease (GSD), but whether central obesity contributes additional independent risk remains controversial. We aimed to comprehensively clarify the effect of body fat…
View article: Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease
Observational and genetic analyses clarify the relationship between type 2 diabetes mellitus and gallstone disease Open
Background The relationship between type 2 diabetes mellitus (T2DM) and gallstone disease (GSD) have been incompletely understood. We aimed to investigate their phenotypic and genetic associations and evaluate the biological mechanisms und…
View article: Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses
Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses Open
Background: While type 2 diabetes mellitus (T2DM) is considered a putative causal risk factor for coronary artery disease (CAD), the intrinsic link underlying T2DM and CAD is not fully understood. We aimed to highlight the importance of in…
View article: Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses
Understanding the relationship between circulating lipids and risk of chronic kidney disease: a prospective cohort study and large-scale genetic analyses Open
Background This study aims to comprehensively investigate the phenotypic and genetic relationships between four common lipids (high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C; total cholesterol, TC; …
View article: Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses
Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses Open
While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has neither been thoroughly examined. We aim…
View article: The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study
The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study Open
Background The coronavirus disease 2019 (COVID-19) pandemic has exerted a profound influence on humans. Increasing evidence shows that immune response is crucial in influencing the risk of infection and disease severity. Observational stud…
View article: Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses
Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses Open
While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has neither been thoroughly examined. We aim…
View article: Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses
Additional Evidence for the Relationship between Type 2 Diabetes Mellitus and Stroke through Observational and Genetic Analyses Open
While type 2 diabetes mellitus (T2DM) is commonly considered a putative causal risk factor for stroke, the effect of stroke on T2DM remains unclear. The intrinsic link underlying T2DM and stroke has neither been thoroughly examined. We aim…
View article: Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer
Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer Open
Background and Hypothesis While the phenotypic association between schizophrenia and breast cancer has been observed, the underlying intrinsic link is not adequately understood. We aim to conduct a comprehensive interrogation on both pheno…
View article: Epidemiological and genetic evidence for the relationship between <scp>ABO</scp> blood group and human cancer
Epidemiological and genetic evidence for the relationship between <span>ABO</span> blood group and human cancer Open
To comprehensively evaluate the etiological role of ABO blood group in human cancer, we conducted a large‐scale meta‐analysis of 127 publications totaling 20 million participants including 231 737 patients of 20 cancers, supplemented by ge…
View article: Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of pulmonary embolism
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of pulmonary embolism Open
Available evidence shows there is probably little or no difference between DOACs and conventional anticoagulation in the prevention of recurrent PE, recurrent VTE, DVT, all-cause mortality, and major bleeding. The certainty of evidence was…
View article: Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis
Oral direct thrombin inhibitors or oral factor Xa inhibitors versus conventional anticoagulants for the treatment of deep vein thrombosis Open
We identified 10 new studies with 2950 participants for this update. In total, we included 21 RCTs involving 30,895 participants. Three studies investigated oral DTIs (two dabigatran and one ximelagatran), 17 investigated oral factor Xa in…
View article: Additional file 1 of Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses
Additional file 1 of Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses Open
Additional file 1: Table S1. Characteristics of genetic instruments of gallstone disease. Table S2. Data sources, sample sizes, number of IVs. Table S3. The detailed search strategy for meta-analysis. Table S4. STROBE-MR checklist of recom…
View article: PROTOCOL: The association between marital transitions and physical and mental health in late life: A systematic review
PROTOCOL: The association between marital transitions and physical and mental health in late life: A systematic review Open
This is the protocol for a Campbell systematic review. The objectives are as follows: What is the association between marital transitions and physical health among people older than 60? What is the association between marital transitions a…
View article: Discordant and inappropriate discordant recommendations in consensus and evidence based guidelines: empirical analysis
Discordant and inappropriate discordant recommendations in consensus and evidence based guidelines: empirical analysis Open
Objective To investigate whether alignment of strength of recommendations with quality of evidence differs in consensus based versus evidence based guidelines. Design Empirical analysis. Data source Guidelines developed by the American Col…
View article: The Impact of Drug Trials With Financial Conflict of Interests on the Meta-analyses: A Meta-epidemiological Study
The Impact of Drug Trials With Financial Conflict of Interests on the Meta-analyses: A Meta-epidemiological Study Open
Background: To assess the impact of trials with potential financial conflict of interests (FCOIs) on evidence synthesis in meta-analyses (MAs). Methods: A total of 96 MAs from the Cochrane Library about drug trials were investigated. The p…